@sokrypton@LeoWanPhD@ranomics So if it can’t predict binding affinity of each mode, then it cannot predict which mode given binding, since these are in one-to-one correspondence via the Boltzmann distribution.
The next wave of AI will not be won by better prompts. It will be won by systems that learn from experience.
Today, Prime Intellect Lab is out of beta, open for you to start training your own models.
The era of self-improving agents is here.
Hello, Moon. It’s great to be back.
Here’s a taste of what the Artemis II astronauts photographed during their flight around the Moon. Check out more photos from the mission: https://t.co/rzM1P0QbOl
How many samples should you sequence?
Collect too few, and the experiment is inconclusive. Collect too many, and the costs add up very quickly.
Check out our bioRxiv preprint and calculator at https://t.co/MrZeo3bTyS! 1/
New from our lab in @NAR_Open:
We dissect the folding dynamics of a fundamental RNA structure—a stem-loop—at single-molecule, microsecond resolution.
A great collaboration with the Shepard & Nuckolls labs, led by @sukjin_jang, @korakray & David Lynall!
https://t.co/6JKvBDubOT 1/4
Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @CellCellPress, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. https://t.co/Zs2Rn35D3s
Ep 332: Not with a Whimper but a Bang
👉https://t.co/Qzvk79o8Bd
Mehmed II becomes Sultan in 1451 and immediately makes plans to conquer Constantinople.
Period: 1448-53
Our paper in collaboration with Hagler lab at TAMU just got accepted ! It’s a super cool webapp for user friendly analysis of DMS data https://t.co/0NiZbY0XDW plus @grantgoneviral and Fede showing the effect of psedoU on a library of a hundred riboswitches - the modifications destroy the ability to switch. This is a big problem for engineering RNA therapeutics with functional structures. But don’t panic, new data from the lab suggests there is sweet spot where a few specific modifications are added that both preserve structure and avoid immune response. https://t.co/cajOp2ouy3
RNA structures are important too! In our latest Technology Feature, Michael Eisenstein explores how researchers are utilizing a growing toolbox of techniques to understand how RNA 3D structures inform their biological function.
https://t.co/zuYgC2cmm4