Gavin

[Brad Gerstner @altcap]

Almost exactly 2 years ago @bgurley & I bet as to when a consumer AI would be able to seamlessly book a hotel room. @noahrshinn & Instinct have made this a seamless reality. Receipt attached. Every person is about to have a world class assistant. Did I win the bet? 🧐💰

[Gavin @Gavin41223502]

@shai_wininger @Lemonade_Inc @Tesla @grok what's the Tesla market size in Missouri?

[Wall Street Apes @WallStreetApes]

This man runs The Better Baker in Edmonton. He’s worked with many influencers giving them free food to promote his business

His business has been under attack by an influencer whose sending an army of trolls to his posts all because he worked with a white person to promote his new croissant

“So my business is currently under attack over a croissant that I made, and it's under attack by an Instagram influencer — she messaged me a few days ago because I launched a new croissant — asked me why it is that I chose a white person to work with”

“I just responded by saying, "I don't pick people based on ethnicity or race." And instead of responding to me, she sent an army of trolls to start saying that I'm culturally appropriating and that I'm tone deaf”

The amount of open racism that’s being tolerated and even celebrated against white people is ridiculous

Th owner says he should be allowed to work with whiten people or anyone from his community

“I'm not sure that telling people — "Hey, don't work with white people," is really what the community needs”

[Gavin @Gavin41223502]

@bryan_johnson Intj you say ?

[Paper Bag Investor @PaperBagInvest]

Using an AI voice-to-text app (I use the lesser known Typeless app) and just talking and sharing all your detailed thoughts, and then uploading that into your LLM of choice to do software coding or changes, really is a superpower setup.

[Daniel Schreiber @daschreiber]

Hey @PaperBagInvest! Really glad you liked the quarter, I confess I did too! But it’s important to me to be responsive to thoughtful questions raised by @DomienVdE and others about Opex, SBC etc. and to share my conviction that everything is on track, per plan, and why @Lemonade_Inc is firing on all pistons, notwithstanding these.

It's been a minute since you last put me on the hot seat. Maybe it's time for us to chat again on camera?

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. Everyone is sharing this study as a skin story. They're burying the part that matters.
Scientists took the aorta of a 75-year-old donor, applied a single engineered enzyme, and stripped away more than 70% of the molecular damage — bringing it down to the levels you'd see in a 30-year-old artery.
Published five days ago in Nature Communications. Revel Pharmaceuticals, with Calico and the University of Colorado.
Here's what they erased.
Sugar reacts with proteins in your body the same way heat browns bread — slowly, over a lifetime. It leaves behind a residue called CML, the most abundant advanced glycation end product in aging tissue. It welds itself onto collagen and elastin in your skin, your eye lens, and your arterial walls.
Two things follow. Your arteries stiffen. And CML latches onto a receptor called RAGE, which drives chronic inflammation — the exact fire I've been writing about for months as the engine of heart disease.
Since the 1980s this damage was considered permanent. Your body has no enzyme to remove it. Every existing approach only slows new damage from forming. Nothing touched what was already there.
So they built an enzyme that doesn't exist in nature. They screened 45,000 protein structures, then ran five rounds of directed evolution across more than 500 million variants until they had CMLase — a molecular lawnmower that oxidizes the CML off the protein and restores the original, healthy lysine underneath.
Not patched. Reversed.
Over 70% cleared from elderly arterial tissue. Over 55% from elderly skin — below the levels found in 31-year-old skin. 45-78% in lens proteins. The CEO said they expected 20% and were floored.
Arterial stiffness drives systolic hypertension, heart failure, and stroke, and I have no drug that reverses it. I can slow the process. I cannot undo it. This paper says undoing it may be possible.
The caveats are real and I won't skip them. This was done on donated tissue in a dish, not in a living person. No functional data yet — we don't know if that artery got measurably more elastic. Delivering a large enzyme deep into human tissue is a hard, unsolved problem. Clinical trials are years away.
But something considered permanent for forty years just came off human tissue.
We spent a century learning to slow aging. Someone finally figured out how to erase it.
Thank you @theallinpod @friedberg @chamath @pesottas

[Jason Kenney 🇨🇦🇺🇦🇮🇱 @jkenney]

The braindead ideology of Canada's left on full and perfect display here👇

Virtually every health care system in the developed world has universal, public access, but permits various forms of private payment.

The social democracies of Scandinavia and Western Europe, Australia and New Zealand, Japan and South Korea, et al.

Canada is an extreme outlier in trying to maintain a rigid state monopoly that prevents innovation, driving desperate Canadians to seek care outside our country.

That's why we are in the top quartile of the OECD on health care expenses, but the bottom quartile on results, e.g. diagnostic and surgical wait times.

But the Canadian left is "horrified" by the idea of adopting aspects of systems with universal insurance that deliver better results at lower cost.

Their message to families desperate for timely care: just keep paying more, and keep waiting longer. Don't you dare step out of line and ask why the French, Swedes, Aussies, or Japanese et al can get faster care at lower cost.

[Ironic Ape @Ironic_Ape]

... Just saying... it ain't bearish.

Assuming loss's stay on the projected trend I have plotted, the new reinsurance and updated Synthetic agent terms could generate an incremental $41m over the next couple years.... continuing the trend of margin expansion, either allowing them redistribute capital for growth or bring forward $LMND net income timeline.. my guess is continued acceleration on growth 🚀🍋

[Gavin @Gavin41223502]

@foundmyfitness @MikhailaFuller One of you has a PhD. The other is an online personality.

[ThePeptideList @PeptideList]

https://t.co/dbqwckY9IV

[Jocko Willink @jockowillink]

Still true.

[Palmer Luckey @PalmerLuckey]

The New York Times did the exact same thing to me. They took a written statement about my political contributions in 2016 (which were still widely and publicly reported as funding extremist trolling and harassment campaigns) and sliced out "through the use of a single billboard" from the middle of the sentence, eliminating a comma and adding a period to make it look like I was talking and admitting to the aforementioned harassment campaigns.

The editors refused to correct it, despite it being absolutely indisputable that they had altered my written statement. They said it did not "materially alter the meaning" and stopped responding when I quoted them the portion of the NYT Style Guide (which was part of my own journalism-school curriculum) that explicitly explains why their alteration was unethical and unprofessional.

[Gavin @Gavin41223502]

@PierrePoilievre @MarkJCarney

[Tablesalt 🇨🇦🇺🇸 @Tablesalt13]

NEW: Canada has sent $3.8 million to the Lebanese Mountain Warfare Ski School

....to ensure their mechanics have multi-gender bathrooms.

[Gavin @Gavin41223502]

@MomAngtrades This is pretty logical, not sure why some would disagree with this.

[Thaïs d’Escufon @ThaisEscufon]

Europeans and American patriots!

Tomorrow, the courts of my country, France, may decide to send me to prison for daring to say on television that “the main danger to women in France is Black African and Arab immigrant men.”

Meanwhile, my own attacker, a Tunisian migrant, is still at large.

I need your help to generate media pressure and hope to be acquitted.

They cannot silence the truth!

Thank you for your support 💪🏻🇫🇷

[Gavin @Gavin41223502]

@elonmusk

[Rupert Lowe MP @RupertLowe10]

The Rape Gang Inquiry - what happens next.

I intend to use my parliamentary privilege to name perpetrators and their enablers in the chamber.

This will be done incredibly carefully with our legal team involved every step of the way to ensure that no future prosecutions are jeopardised.

We are cooperating with the authorities in order to help cases be opened and reopened, but my faith in the system to independently deliver justice is not high...

That is why we are pursuing private prosecutions and civil litigation.

A target list has been identified, and it continues to grow.

This all has to be handled very carefully, for obvious reasons, but I am determined to act. We have had enough talk, now we need to act.

Our aim is straightforward.

Put people in prison. Deliver justice. Finally.

We will act. Not talk.

[Shai Wininger @shai_wininger]

@SemiChurn @MadsLRosendal @nefthy @FelixKern2 @NathanKohn @korndaniel1 @daschreiber @Maya_Prosor @tebixby @audrey_zada @Lemonade_Inc Apart from agentic coding and reasoning, we use third-party models for boring stuff like data extraction and formatting.

The core pricing and UW precision, which I consider to be our real moat, come from our own models such as LTV13.

[David Sacks @DavidSacks]

I’ve had a number of conversations with folks inside and outside government about the current situation with Anthropic, and here is what I believe to be true:

— As we know, Anthropic publicly released its Mythos class models earlier this week under the commercial name Fable.

— Fable is Mythos with guardrails. But if those guardrails fail, then you’ve exposed Mythos and its advanced cyber capabilities to people who shouldn’t have them. (Keep in mind that Anthropic itself widely promoted the idea that Mythos was a cyberweapon and needed to be regulated as such. They asked for government regulation of Mythos and championed the guardrails on Fable. If there is a vulnerability — big or small — it is Anthropic’s responsibility to patch.)

— A highly credible trusted partner of both Anthropic and the USG who was testing Fable came forward with a jailbreak of those guardrails. The Admin asked Dario to fix the jailbreak or de-deploy the model. Dario refused.

— In their blog post, Anthropic defended its decision by saying the jailbreak isn’t serious. That is not what the trusted partner and the USG believe; nor is that kind of minimizing language consistent with Anthropic’s brand as the AI safety company. It’s difficult to fathom how they could claim a jailbreak allowing operability of a cyber weapon could be defined as not “serious.”

— In the past, Anthropic has always said that safety must be top priority and taken super seriously. In this case, Anthropic prioritized the continued offering of the consumer model over safety.

— In reaction, the Admin issued the export control. The Admin did this reluctantly. It’s been very surprised that Anthropic hasn’t wanted to cooperate with a reasonable safety request (ie fixing the jailbreak issue). Anthropic’s reaction is very much at odds with their branding and ethos as a safe AI research community.

— The Admin’s hope now is that Anthropic remediates the safety issue, the export control is lifted, and Fable goes back into general release. The Admin wants all of this to happen as soon as possible. It is frankly bewildered that Anthropic hasn’t wanted to comply with safety requests that it previously said were its highest priority.

— Those trying to misdirect and tie this action to the prior DoW/Anthropic issues are wrong. The Admin values Anthropic’s technical capabilities and feels that this issue, while serious, should be easily resolved. The ball is in Anthropic’s court.

[Michelle Rempel Garner @MichelleRempel]

I wonder why @elonmusk, who is Canadian, decided not to build his civilization-changing, historic-levels-of-wealth-creating companies in Canada?

It will remain a mystery.