Thomas Gregor

Scientist - Biophysicist

[@alexandremayran.bsky.social @AlexandreMayran]

Happy to share our collaborative effort showing a temporal decoupling between morphogenesis and transcription during gastruloids self-organization
https://t.co/DWWmYW3iG5

[Shashi Thutupalli @stpalli]

Thanks @LecuitLab @PrakashLab @briscoejames Frank J, Ed M and Aleks W for spoiling us all with an incredible richness of discussions and ideas at the meeting.

Was also quite special that three of us @NCBS_Bangalore colleagues were there together!

[Denis Duboule @Duboule]

Sunny day over wonderful Paris from a terrasse at College de France @cdf1530😎Kick-off meeting 🚀of the @ERC_Research synergy #DynaTrans program with the Gregor @gregorscience @institutpasteur and #Tkacik labs @ISTAustria #gastruloids #chromatin #models #bursts on the menu🤘

[Thomas Gregor @gregorscience]

@krish_iyer92 @dbjc_bdbc Yes, I had heard... many thanks! she did an amazing job! those statistics are unequaled. diligence and perseverance pay in the end; but hard to get there!

[Thomas Gregor @gregorscience]

We made it: the first paper from the Pasteur lab! Many thanks to a wonderful team for their trust and for accompanying me on this new adventure! You guys rock!
https://t.co/YxZ0pRd6W4

[Thomas Gregor @gregorscience]

Gastruloids develop in an artificial context where boundaries are created through spontaneous self-organization. No selection pressure has acted on the system to operate at such high levels of precision. These properties could thus be fundamental features of multicellularity.

[Thomas Gregor @gregorscience]

Our results reveal developmental precision, reproducibility, and size-scaling for a mammalian system that, unlike, e.g., a fly embryo, is not constrained by fixed boundary conditions (i.e., an eggshell).

[Thomas Gregor @gregorscience]

We demonstrate an intrinsic reproducibility of the self-organizing anteroposterior body axis in gastruloids, both for growth dynamics and gene expression patterns. The system exerts tight control over expression levels and positions pattern boundaries with single-cell precision.

[Thomas Gregor @gregorscience]

This is the read-only link of the peer-reviewed paper, a manuscript of which has been on arXiv since March 2023: https://t.co/l9UR849tFp

[Denis Duboule @Duboule]

Please RT 🙏. And join us, will be fun! Paris rocks🤘@cdf1530 @EPFL @the_Node @The3DGenome @3D_Genome @sfbd_biodev

[David Brückner @d_brueckner]

📢New preprint!

Developmental systems have a remarkable ability to self-organize spatial patterns of different cell types.

How can we quantify the information content & robustness of these self-organized patterns across biological systems?

👉https://t.co/44GpDFNe7M

[StarkLab @stark_lab]

We are very excited to present a major breakthrough achievement – the de novo design of synthetic enhancers for selected tissues in fruit fly embryos in vivo using deep- and transfer learning, @deAlmeida_BPet al published today in @Nature https://t.co/TIlPrBKYaK. Thread 👇(1/N)

[Denis Duboule @Duboule]

This rocks! #DynaTrans @gregorscience #GasperTkacik @cdf1530 @EPFL @UNIGEnews @institutpasteur
https://t.co/0d88WiwEBu
ERC Synergy Grants back 37 teams to tackle complex scientific questions | via @ERC_Research https://t.co/iM6DXK8g7X

[James Zou @james_y_zou]

How well can #GPT4 provide scientific feedback on research papers? We study this Q in our new work https://t.co/XJxwaecqy6

We created a pipeline using GPT4 to read 1000s papers (from #Nature, #ICLR, etc.) and generate feedback (eg suggestions for improvement). Then we compare with human expert reviews.
👍 Most authors found GPT4 generated feedback helpful*
👍 >50% of points raised by GPT4 also raised by >=1 human reviewer.
👍 Overlap between GPT4 and human feedback similar to overlap between 2 human reviewers.
👎 GPT4 can struggle with in-depth critique of study methods; sometimes more generic.

Takeaway: high-quality human feedback still necessary; #LLM could help authors improve early drafts before official peer review**.

Work of a great team led by @liang_weixin @Zhang_Yu_hui @CaoHancheng 👏

*Our survey was opt-in and could have selection bias.
**Reviewers should still engage w/ papers independently w/o relying on LLM.

[Chris Shaw @kalahar1]

What we talk about when we talk about climate change. A short(ish) thread.
1. What is presented as climate action is actually action intended to legitimise liberalism in the face of a catastrophe for which liberalism has no answers. Here's how it's done 1/10

[Physical Review Letters @PhysRevLett]

The minimum energetic cost associated with intracellular information transfer is far larger than that necessary for the decision-making constraint on the physical conditions under which living systems operate
Letter: https://t.co/WqLOF9eJsv
Viewpoint: https://t.co/5mGBZSwqxG

[Mo Khalil @MoKhalilLab]

PAPER! Come learn how we used synthetic circuits to investigate how specificity is achieved in gene networks, and how to apply these insights to engineer gene circuits with stable, evolutionarily-robust functions. Reported today in @CellCellPress!! 1/n

https://t.co/bhJD7QPZMu

[Dr Naomi Moris @nmoris]

And we are carrying on the detective story in @LabMoris now! 🔎 In fact, we are hiring a postdoc to carry this project forward, so please apply if you ❤️ PGCs and want to play with glds🍤 - or spread the word + RT! 🙌 (6/6) https://t.co/HMxR25QWXX

[Richard Sever @cshperspectives]

This is why I wrote this article. We need to decide why/which/how/where for data archiving. Otherwise there's a danger of pointless bureaucracy https://t.co/oDHPxPMDVd

[Denis Duboule @Duboule]

if you are an independent postdoc interested in Dev. Biol, Evo, Gene regul, Chrom structure and you like to join a new lab @CirbCdf in Paris working on long-range gene regulation in ESC-derived pseudo-embryos, please contact [email protected] 🙏RT