Gregory F. Phillips

[Gregory F. Phillips @gregory_f]

https://t.co/BpQrjGoJUB

[Gregory F. Phillips @gregory_f]

@1Password Thanks for the reminder.

[1Password @1Password]

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[Karl Mehta @karlmehta]

Demis Hassabis explains the 99% in-silico drug discovery pipeline that turns wet labs into validation labs

"I'd argue we've already had one of those moments with AlphaFold. It's a 50 year grand challenge, protein folding and the 3D structure of proteins"

"It's an incredibly important thing to know about if you want to design medicines or if you want to understand biology"

"Isomorphic Labs is to build adjacent technologies in more biochemistry and chemistry space that can actually design the compounds automatically to fit and bind to the right part of the protein"

"The dream is to do almost all the exploration, which is 99% of the work and the time, in silico, and then save the wet lab step just for the validation step"

"We could reduce drug discovery times instead of taking an average of 10 years down to months, maybe even weeks, and perhaps even days one day"

Most people still think AI biology means faster papers or better search. Demis is describing a different operating model: compute explores the chemical space, the wet lab validates, and drug discovery compresses from decades to iteration cycles.

If AlphaFold was the proof that AI could read biology, Isomorphic is the bet that AI can start writing medicine.

- Demis Hassabis (@demishassabis), CEO of Google DeepMind, at Sequoia AI Ascent (@sequoia)

[Ishika Rawat @Ishh_021]

Anthropic engineer:

"You're not supposed to prompt Claude. You're supposed to build a system that prompts itself."

In 45 minutes she breaks down how Anthropic builds agents that remember, learn from their mistakes, and get smarter with every run.

Worth more than any paid course you'll find on building agents.

Watch the session

[Gregory F. Phillips @gregory_f]

https://t.co/vv0uNr1WJF

Wow

Stay Humble Folks,
~Greg

[Ishika Rawat @Ishh_021]

Anthropic engineer:

"You're not supposed to prompt Claude. You're supposed to build a system that prompts itself."

In 45 minutes she breaks down how Anthropic builds agents that remember, learn from their mistakes, and get smarter with every run.

Worth more than any paid course you'll find on building agents.

Watch the session

[Dan Mall @danmall]

I watched an agency owner lose 20 lbs. over 3 weeks from stressing over payroll.

Doing great design work and running a great design agency are two different jobs. Maybe you went to design school. Did you go to design business school?

You learn to price engagements by guessing. You learn to pitch by losing the deal. You figure out positioning years after you needed it, usually right after a client you built the business around walks.

I spent 20 years learning how to run a business the slow, expensive way:
↳ 10 years working for agencies, making a mental list of what to keep and what to throw out
↳ 10 years building my own agency, learning by screwing things up

Then I spent the last two years putting all of it in one place so you don’t have to spend the same 20 years that I did.

It’s called the Field Guide. It‘s every framework I know for running an agency—pricing your engagements, pitching without flinching, positioning so the right clients find you, and a map for what to fix next—as a library you go through on your own time.

[Tulsi Soni @shedntcare_]

🚨 Goodbye video editing.

Someone built a free AI video editor for Claude Code… and it’s insane.

Just drop your:
• Raw footage
• Assets
• B-roll

Into a folder.

The AI handles everything:

• Cuts clips
• Removes filler words
• Adds subtitles
• Applies color grading
• Adds animations
• Renders the final video

No timeline.
No manual editing.
No endless tweaking.

It edits the entire video for you.

And yes, it's open-source on GitHub.

The project is called Video Use.

To celebrate, I'm giving away 10 Claude Pro subscriptions.

To enter:

1. Like this post
2. Repost it
3. Follow @shedntcare_
4. Comment "VIDEO"

Winners will be picked in 48 hours.

Video editing will never be the same.

[TechCrunch @TechCrunch]

Ubisoft co-founder Claude Guillemot dies in plane crash https://t.co/hgmsP8WdBZ

[Grace Gym🏋️‍♀️ @GraceGym_]

Life hacks my dad taught me 👇

[Luke Wroblewski @LukeW]

in just a few years, developers went from writing code to steering groups of autonomous agents that write, test, and ship it. the rest of us are next. what does that mean for the role of humans in AI products?

[Luke Wroblewski @LukeW]

see it here: https://t.co/JtLFXGWHbo

[Luke Wroblewski @LukeW]

you can throw a complete garbage PDF form at it and a highly usable, design best practice abiding form pops out the other side in minutes.

[Gregory F. Phillips @gregory_f]

https://t.co/wtMRxbRjsz

[Dan Mall @danmall]

My birthday was earlier this week.

Next week, I’ll give you a present… a giveaway I’ve never shared publicly before and only teach to my agency owner students.

But today, I’m asking YOU for a present.

🎁 Give me some advice.

Anything.

What wisdom do you have that I might benefit from having too? What have you shared with others that has brightened their day or improved their lives?

Tell me what to do. Sometimes it’s nice to have someone tell you what to do. Simplifies things.

Share something. An item I should buy. A class I should take. An experience I should have. Especially if you’ve been following me for a while and know the kind of stuff I’m into, recommend something you think I’d love.

I’m open.

Whaddya got?

[Gregory F. Phillips @gregory_f]

@danmall Experience: Spend some time at Earthaven Ecovillage outside of Asheville, NC. They have some amazing workshops for couples and individuals to connect.

[Luke Wroblewski @LukeW]

metaphor I've been using to describe the agent orchestration UI in Intent:

in the real-world, if you want to accomplish a large or complicated task you need:
- a team of the right people for the job, often specialists
- to give the team the information they need to complete the job
- the right environment where the team can coordinate and work safely

this approach applies to more than just software development.

[Addy Osmani @addyosmani]

Announcing big changes to Gemini in Chrome - agentic browsing with Auto-browse, Nano Banana & more! 🚀

[Luke Wroblewski @LukeW]

features used to be what shipped in the last release. now they're what people ask for in the next session. @reve Effects are software features made on-demand.

[Gregory F. Phillips @gregory_f]

Witnessed the historic Walk of Peace in CLT last night. In 22 years of practice, I’ve never seen this level of acceptance here. As monks walk through neighborhoods strained by growth today, I ask: How might we design our cities to prioritize compassion as much as expansion?

[Gregory F. Phillips @gregory_f]

https://t.co/M9tf0CZhcF