Harsh

managing partner @wireframevc｜ex: founder, engineer, natsec investor｜husband & father｜india ‣ chicago ‣ sf

[Harsh @harsh1]

@vassallo @andrewdfeldman @cerebras Incredible Steve, what a ride.

[Harsh @harsh1]

@jonahkallenbach @agupta @AnthropicAI Congratulations Jonah! Happy for you.

[benja @benjaminakar]

Introducing @tembo

The unified interface for background coding agents.

[Harsh @harsh1]

@agupta That’s awesome news Ankit! Congratulations. Next gen of YC founders lucky to have you on their side.

[Harsh @harsh1]

@viswacolluru & the amazing team @lifeschemistry have been defying the odds from the moment we invested in 2019. What began as a contrarian premise has driven an extraordinary clinical pipeline being recognized by both capital markets and pharma. Congratulations!

[Enveda @lifeschemistry]

How we built a unicorn from seed in 5 years…

There are no secrets, but purpose, pace, and an incredible team certainly help.

“We’re combining ancient ancestral wisdom with the power of nature’s chemistry with modern AI and drug discovery,” Colluru said. “We’re standing on the shoulders of maybe the giant, which is Mother Nature.”

Read more by @damiangarde in @business about how we raised our Series D, advanced our lead candidate in atopic dermatitis to Phase 1b, and brought on a pharma legend Mikael Dolsten as we prepare to enter more programs in the clinic this year... and stay tuned for more.

#Unicorn #Startups #AI #DrugDiscovery #Nature

[Harsh @harsh1]

Proud to work with @DaneshSamy & @theCyrusJia to bring Argon AI's vision to life. Their AI intelligence platform helps biopharma teams make smarter, faster decisions – accelerating time-to-market for life-changing medicines.

[Samy Danesh ∞ @DaneshSamy]

Exciting milestone for Argon AI—we’ve raised a $5.5 million seed round led by @CrosslinkCap and @WireframeVC , with support from @ycombinator , @pioneer_fund , and industry operators.

Grateful to our customers for their trust and our investors @ThePhilBoyer, @harsh1, @DaveMessina, @SurbhiSarnaSF and countless others for believing in Argon's vision.

We believe AI will fundamentally reshape how biopharma companies and life science consultancies operate.

Argon's mission is to give biopharma & life science consulting teams an AI-native workspace that turns scattered data into decision-ready insights in minutes—not weeks.

Early partners are already elevating their teams away from the data-drudgery that plagues the industry towards higher-order tasks — science, strategy, and domain specific taste and intent.

This capital lets us accelerate building new products and features to delight our partners.

And huge kudos to the Argon team—your speed and grit make the impossible routine!

Onward!

[Enveda @lifeschemistry]

Why we are here...

At Enveda, we’re unlocking the secrets of life’s chemistry and harnessing billions of years of evolution to bring #hope to those we love.

We are proud to tell our story in #TheNextFrontier, a global series presented by the @Biotechnology Innovation Organization and produced by @BBCStoryWorks Commercial Productions.

Together with world-renowned biochemist and bestselling author Nick Lane, as well as leading metabolomics researcher, Pieter Dorrestein, we delve into how nature, one of the most powerful yet unexplored sources of medicine, is helping us understand the molecular basis of life and guiding us to develop groundbreaking treatments for today’s most urgent health challenges.

Watch here: https://t.co/hTqiEPY8ex

Catch the live launch at #BIO2025 in Boston: June 18 | AM ET| Storytelling Stage – and a discussion with our CXO Dan Wee, PhD at AM ET. What breakthroughs are you hoping are hidden in life’s chemistry?

[ry @rywalker]

Looking for cracked entrepreneurial devs to join us in building the world's first "Async AI Software Engineer"

DMs open :)

[Wireframe Ventures @WireframeVC]

Climate resilience is a new market being built in real time. At our #SFClimateWeek2025 panel on Engineering Global Resilience, leaders from Google, Gridware, Understory & Nephila shared challenges & new tech approaches to managing climate risk 👇 https://t.co/KVnQN1LBiD

[Harsh @harsh1]

@Kristine1ise @EniacVC Congratulations Kristin! Wonderful news.

[Harsh @harsh1]

@vassallo @ashugarg @fifaifofo @joannezchen @FoundationCap Congratulations Steve!

[Harsh @harsh1]

@janiceschen Congratulations Janice! Enjoy this time.

[Harsh @harsh1]

@vicsingh @RRE 💥amazing, congrats

[Harsh @harsh1]

Any new founder in techbio / platform bio should read this from Ankit. Clear insights for this category that you should fully appreciate before you start.

[Ankit Gupta @agupta]

With the start of my first batch as a visiting partner at @ycombinator, this felt like a good time to write my founder story about our journey at @reverielabs. It's a bit of a long one.
https://t.co/KWyMxPDdXO

[Harsh @harsh1]

@agupta @ycombinator @reverielabs Thanks for writing this, such valuable insight for new bio founders. And congrats on the YC role!

[Wireframe Ventures @WireframeVC]

We’ve seen Enveda grow from pre-seed to a $130M Series C and their first clinical-stage program in just 5 years. @lifeschemistry is redefining drug development with a cutting-edge platform that unlocks nature’s untapped chemistry 🌿💊

https://t.co/zRqNjBRshc

[Harsh @harsh1]

Why I'm so excited to have @lbernicker as a partner. She's been an incredible addition to our team, and this is just the beginning.

[Wireframe Ventures @WireframeVC]

We are thrilled to announce the promotion of Lily Bernicker to Partner at Wireframe Ventures 🌟 Read more about her journey and why we’re so proud to have Lily on our team https://t.co/GY6it93Tvi

[Harsh @harsh1]

5 years from pre-seed to clinical stage is unreal execution from this team - and so much more to come 👏🏽

[Viswa Colluru @viswacolluru]

Today the emotions are many but words are few. I’ll save the latter for a longer post soon. Let’s go @lifeschemistry ! 🚀

[Harsh @harsh1]

@Nish67 @BBGVentures Congratulations Nisha!! Amazing news.

[Wireframe Ventures @WireframeVC]

We’ve been enthusiastic supporters of Bruce Beutel & Passkey Therapeutics since their pre-seed round. Read why we were excited to back this team & their pioneering approach to unlocking complex disease biology through a new class of multifunctional drugs🧬https://t.co/h63ibmGTol