Top Tweets for #6mASCOPE
SUPERB work: @kong_yimeng! also 1st author of #6mASCOPE where we focused on bacterial contamination to address debate over DNA 6mA in eukaryotes. But the DEEPER question was about SOURCE of false positives in previous studies, which we try to answer here. π@NatureRevGenet 11/11
However, ALL mapping technologies have certain limitations, making false positive and/or false negative calls. If not well recognized, these limitations can create confusions: a few examples, e.g. our #6mASCOPE paper assessing DNA 6mA in eukaryotes https://t.co/7OjT58KN4A, 3/11
Yimeng Kong @kong_yimeng in our group will present @PacBio journal club (1pm EDT, 6/29) our recent #6mASCOPE work @ScienceMagazine, a meta-epigenomics approach to assess DNA 6mA #methylation in eukaryotes. Please see link below to register π https://t.co/W1SCGxhrg3
@akc1221 @CSHL @PacBio Great knowing, Amanda! @kong_yimeng, first author of our recent #6mASCOPE paper will also be there. Would be a great meetup!
Research Highlight by @naturemethods covering our recent #6mASCOPE paper @ScienceMagazine https://t.co/7OjT58KN4A Thank @DrLeiTang for the coverage.
https://t.co/4OzyCJYZxA
@greally @mason_lab @PacBio @NIH Thanks for your interest. Just wanted to add that it is still possible DNA 6mA is abundant in certain conditions or diseases. So our study mainly hope people to raise caution for bacterial contamination in previous, ongoing and future studies, and use #6mASCOPE to examine.
A Research "In Brief" @NatureRevGenet highlighting our recent #6mASCOPE paper "Critical assessment of DNA adenine methylation in eukaryotes using quantitative deconvolution" @ScienceMagazine https://t.co/7OjT58KN4A Thank @dotclyde for the coverage.
SCOPE-ing out eukaryotic 6mA https://t.co/PqXDME4mkm #InBrief
A great perspective by Konstantinos Boulias and @EricGreerLab that described the background of DNA 6mA discovery, the debate, the challenges, our #6mASCOPE paper and future explorations. https://t.co/jiE33BdYTJ
Applying #6mASCOPE, we observed high-resolution 6mA deposition in two protozoa. However, we found that commensal or soil bacteria explained vast majority of 6mA in insect and plant samples. We find no evidence of high abundance of 6mA in Drosophila, Arabidopsis, or humans 6/10
A key challenge was that no existing tool can *quantitatively* examine 6mA, *separately* for eukaryote & bacteria in a gDNA sample. To address this, we developed #6mASCOPE: 1) a #metagenomic approach that examines 6mA in every read, eukaryote & bacteria i.e. #metaepigenomics 4/10
Glad to share our work @ScienceMagazine by @kong_yimeng et al. addressing a debate over DNA 6mA in eukaryotes. A new method, #6mASCOPE, takes a #metagenomic approach for #epigenomics https://t.co/7OjT58KN4A Interested in DNA #methylation? or long read sequencing? Here is a π§΅1/10
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