Top Tweets for #BladderSparing
Radical cystectomy is NOT the only standard for MIBC anymore. 🚻🔥
The International Bladder Cancer Group just made it crystal clear in European Urology 📘
If you remember ONE thing, remember this 👇
🧠 TMT = TURBT + RT + Chemo
That’s bladder preservation.
That’s guideline backed.
That’s no longer niche care.
Who wins with TMT 🎯
🟢 Single tumor
🟢 cT2
🟢 No hydronephrosis
🟢 No multifocal CIS
🟢 Good bladder function
Big myth busted ⚠️
cT3–4, CIS, hydronephrosis
👉 Worse prognosis ≠ absolute no
The safety net that makes this work 🛟
If local failure happens
👉 Early salvage cystectomy still cures
What is NOT routine 🚫
❌ Partial cystectomy for most
❌ Radical TUR alone
❌ Skipping local therapy after chemo or IO outside trials
One line takeaway 💡
If you never discuss TMT, you are denying patients a real option.
Would you offer TMT to every eligible MIBC patient ❓
📖 Full paper in comment ⬇️
#BladderCancer #UroOncology #OncoTwitter #MedTwitter #EAU
@OncoAlert @myESMO @ESMO_Open @Uromigos
Bladder removal surgery can have a big impact on quality of life. Study S2427 (also called BRIGHT) is testing a possible #BladderSparing approach for people with muscle invasive #BladderCancer. To learn more, visit https://t.co/WWqP6qxd2M or call 1-800-4-CANCER. #MIBC
Great consensus initiative for #endpoints for #BladderSparing treatment
✅EFS as acceptable primary endpoint (definition dependent)
☑️cCR possibly, but not acceptable (yet) as regulatory EP
➡️More work needed on evidence generation + endpoint validation @oncodaily #BladderCancer
End Points for the Next-Generation Bladder-Sparing Perioperative Trials for Patients With Muscle-Invasive #BladderCancer
https://t.co/oEmYVTb6zp
This study presents international consensus recommendations from the IBCG and GSRGT on standardized outcome measures for evaluating bladder-sparing strategies in muscle-invasive bladder cancer (MIBC). Through expert panels and a modified Delphi process, the group defined clinical complete response (cCR) as the absence of high-grade disease on pathology and imaging, suggesting it as an endpoint for early-phase trials. Event-free survival (EFS) was endorsed as the preferred primary endpoint in registrational studies due to its ability to capture long-term treatment benefit.
The framework emphasizes risk-adapted approaches and patient-centered decision-making in perioperative therapy.
@AndreaNecchi
@NazliDizman
@Dr_Aggen
@neerajaiims
@h_alahmadie
@apolo_andrea
@l_ballas
@pcvblack
@GiorgioBre
@LiangChengMD
@AlessiaCim
@siadaneshmand
@drjefstathiou
@filicevas
@PGrivasMDPhD
@shilpaonc
@AlexiaIasonos
@Prof_Nick_James
@y_loriot
@UroMoschini
@montypal
@ERPlimackMD
@drgaganprakash
@spsutkaMD
@DrRosenbergMSK
@BogdanaSchmidt
@sonpavde
@MariePierStLau1
@SpiessPhilippe
@UroDocAsh
#OncoAlertAF
@nataliagandur @acampsmalea @BRicciutiMD
@yekeduz_emre @HHorinouchi @FadiHaddad_MD
@Abdallah81MD @FernandoOnco
@ElisaAgostinett @to_be_elizabeth @bavilima @realbowtiedoc @Erman_Akkus @Lucarecco @GaiaGriguolo @JankovicK
@MarioBalsaMD @DrMirallas @GIMedOnc @OscarTahuahua
Wonderful stuff, thanks @DrFelixGuerrero!
We spend our lives saying this, great to see that you and your co-authors agree!
#BladderCancer #NMIBC #BCGFailure #BCGU #BladderSparing #HIVEC
📄Thrilled to share our most recent paper in @Current_Urology
🔥Intravesical hyperthermia for BCGu NMIBC
👓Read it: https://t.co/sAGD6hGjFS
🔝Co-authors @cgdelcanizo @MarioHArroyo @josedsh @BenjaminPradere @evanguelosx @Urologia12
@jteoh_hk as Editor
‼️Really important and to be considered for all #BladderSparing strategies QoL after #RadicalCystectomy must not necessarily be worse compared to bladder sparing therapies with repeat and partially systemic treatments - or even better #AUA2025
Speechless QOL better after cystectomy #AUA2025
De-Escalating treatment based on serial #Biomarker #ctDNA assessment should be the goal in #MIBC #BladderCancer @DrJohnSfakianos
👉This could not only mean #BladderSparing but also removing neoadjuvant treatment and do #RadicalCystectomy w/o systemic treatment #EAU2025 @uroweb
#EAU2025 Great @ANZUPtrials session covering various GU oncology topics
@evanguelosx talking about #BladderSparing approaches in #MIBC:
👉Trimodal therapy is an option
👉Complete #TURBT is essential
👉Studies are needed evaluating biomarker driven strategies @oncodaily @Uroweb
The right questions addressed by @PGrivasMDPhD after NIAGARA trial presentation:
❓should we proceed with adjuvant treatment in ypT0?
❓Is there a role of ctDNA for adjuvant treatment decisions
❓can pts be cured with systemic therapy #BladderSparing approach?
@oncodaily #MIBC
Brilliant discussion by @PGrivasMDPhD about NIAGARA trials focused on different roles of neoadj vs. adjuvant part of the study and future perspectives opened by this study. @BladderCancerUS @OncoAlert @GUOncologyNow
Guidance for #BladderSparing treatment @IBCG_BladderCA #BladderCancer
✅Several treatment options available to explore bladder sparing approach safely
✅Thorough clinical response assessment needed (consider PDD)
✅ TMT/RC in case of failure
@UroDocAsh @oncodaily @shilpaonc
⚡️ Bladder-sparing Therapy for Bacillus Calmette-Guérin–unresponsive Non–muscle-invasive Bladder Cancer: International Bladder Cancer Group Recommendations for Optimal Sequencing and Patient Selection
#BladderCancer @OncoAlert @shilpaonc @h_alahmadie @UroDocAsh
https://t.co/fr15SM7URy
#BladderSparing treatment and sequencing recommendations for patients with #BCG unresponsive #NMIBC
✅Use the right definition for BCG unresponsiveness
✅Optimal staging needed incl. imaging + re-TURBT
✅Beyond available treatments counsel patients for clinical trials
Timely! Just out from #IBCG23 as we wrap up #IBCG24:
Bladder-sparing Therapy for BCG–unresponsive NMIBC: International Bladder Cancer Group Recommendations for Optimal Sequencing and Patient Selection
https://t.co/n9eRbTjbK4
@IBCG_BladderCA @WorldBladderCan @BladderCancerUS @EUplatinum #BladderCancer
SURE-01: neoadj SG +/- pembro in #MIBC #ASCO24
✅ 36% pCR/45% ypT≤1N0 (RC) + 6/7 pts refusing RC with clinical CR (MRI/cysto/ctDNA/TURBT-)
👉 potential #BladderSparing approach?
🔹Proper AE management required #GCSF
@oncodaily @urotoday @AndreaNecchi @Anto_cigliola @ASCO
Missing #ASCO2024 since my flight got me back home again instead to Chicago
Joining virtually instead: Advancements in #UrothelialCancer Care was a great session #PooiaGhatalia
▶️@MattGalsky Biomarker guided patient care #ctDNA
▶️@brentrose #BladderSparing Treatment Strategies👇
膀胱癌の膀胱温存療法。放射線治療を組み合わせていないため、救済膀胱全摘の可能性が残せるのがよい気がします。 #bladdercancer #bladdersparing #MIBC #筋層浸潤性膀胱癌
https://t.co/BkwDHGgUXX
📣 Our President will be speaking at #EAU23 next week!
➡ During this session, delegates will be informed about differences in the quality of life of #MIBC patients treated by #radicalsurgery versus #bladdersparing treatment.
Learn more here 👉 https://t.co/gJ82lmAa7U
❓How to start #bladdersparing in your patients with muscle-invasive #bladdercancer?
❓Is patient pathway including "best of both worlds" possible?
➡️ We tried to address these issues in our latest #review in @JCM_MDPI
https://t.co/7GCTDZu6IG
Join us for a data driven discussion on #bladdersparing/tmt today. Register at: https://t.co/lOGFCuTdk8
@LonestarUroDoc
@UroCancer
Join us for a data driven discussion on #bladdersparing/tmt on July 12th. Register at: https://t.co/gSiSUkfC7g @LonestarUroDoc @UroCancer
Together with a 🌟team of #bladdercancer experts - we wrote a review of/wish list for #clinicaltrials investigating ways to📈QoL without sacrificing outcomes in tx of #MIBC via #bladderpreservation and #bladdersparing https://t.co/S2Ettm3Eqf (no paywall)
#BladderSparing treatment options for muscle-invasive #BladderCancer. @AndreaNecchi @SanRaffaeleMI joins @UroDocAsh @MDAndersonNews for an in-depth discussion on UroToday. #WatchNow > https://t.co/DjTrZLZQIf @MyUniSR
#BladderSparing treatment options for muscle-invasive #BladderCancer. @AndreaNecchi @SanRaffaeleMI joins @UroDocAsh @MDAndersonNews for an in-depth discussion on UroToday. #WatchNow > https://t.co/DjTrZLZQIf @MyUniSR
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