Top Tweets for #CardiacAging
⭐ JCA Featured Article
Cardiomyocyte senescence and the potential therapeutic role of senolytics in the heart
👤 Corresponding author: Junichi Sadoshima (USA)
🔗 https://t.co/5SAyMG09OP
#CardiacAging #Senescence #Senolytics
How might extracellular vesicles support cardiac regeneration and protect against age-related cardiac decline?
🫀 JCA Featured Article
Extracellular vesicles in cardiac regeneration and aging: mechanisms and translation
🔗https://t.co/mILorWyIm3
#CardiacAging #CardiacRegeneration
A Novel Mechanism of Cardiac Aging and Disruption of The Neurovascular Network - Abhilasha Singh
@ScienceMagazine
https://t.co/r3MZtEa0ks
#Health #Hematology #Hemostasis #HemostasisNews #HemostasisToday #Medicine #Science #CardiacAging #MedEd #MedX
@kamil_kobak 🎉Welcome Kamil Kobak to Youth Editorial Board of JCA!
Research Interests: cardiac aging, age-related cardiovascular diseases, HFpEF, proteostasis, skeletal muscle dysfunction, and inter-organ crosstalk.
#CardiacAging #HFpEF #Proteostasis
"Metabolic Targets in Cardiac Aging and Rejuvenation" 🫀🔬
Explore how metabolic pathways drive heart aging—and how they might be rewired for rejuvenation.
📖 Read more:
https://t.co/0aGN8h5zyY
#CardiacAging #Metabolism #Rejuvenation #HeartHealth #AgingResearch #OpenAccess
🚨Great Review Alert!
The mTOR signaling pathway in cardiac aging 📷
https://t.co/m6y1TVjObv
#CardiacAging #mTOR #AgingResearch #Cardiology #MolecularBiology #Autophagy
Rheumatic valve disease and acceleration of cardiac aging in Africa: next-generation answers for an old, orphan problem #RheumaticHeartDisease #CardiologyAfrica #CardiacAging. Read more in the @EHJ at https://t.co/8cqULuESXy @ESCardio @ESC_Journals
Heart #Lymphangiogenesis #Aging #Exercise
#CardiacAging (20- vs 2-mo♂️🐭)
⏬Lymphatic vessel density
⏫initial & collecting lymphatic φ
⏬Lcollecting lymphatic VE-cad junction
#Exercise (6-wk voluntary wheel running) in aged🐭
⏫Lymphatic vessel density
⏬epicardial (&👂skin) lymphatic φ
⏬peri-lymphatic immune cells
⏬peri-lymphatic fibrosis
⏫peri-lymphatic cardiomyocyte size
⏫cardiac lymph flow
@Aging_Cell 2025
https://t.co/QafCo758Tu
📢New Open🔓 Access Paper Alert
The effect of enhanced glycolysis on cardiac aging by Anna Faakye & Kenneth M. Humphries et al.
https://t.co/A3u1EOIECD
#cardiacaging #glycolysis #mitochondria #oxidativestress #proteostasis
New publication from our lab with lots of contributions from my great @AM_OMRF colleagues. We examined the effect of enhanced glycolysis on cardiac aging. Read the full article here:
https://t.co/IkNpIcyTav
@GeroScienceAGE
Meet Dr. Katarzyna Cieslik
Dr. Katarzyna Cieslik, Research Prof. at @MethodistHosp, explores sex-specific ECM changes in the aging heart.
Join her at #AGEAnnualMeeting2025.
🔗 https://t.co/rixU77uKo6
#CardiacAging #ECM #SexDifferences #HeartHealth #LongevityScience
❤️ Meet Dr. @AnnChiaoPhD!
Assistant Member at the Oklahoma Medical Research Foundation @omrfscientist uncovering how NAD⁺ transport shapes cardiac aging. Catch her session at #AGEAnnualMeeting2025!
https://t.co/rixU77uKo6 #CardiacAging #HealthyAging #Geroscience
📢New Open🔓 Access Paper
Cardiac-specific overexpression of serum response factor regulates age-associated decline in mitochondrial function by Pankaj Patyal & Jeanne Y. Wei et al.
https://t.co/FClp3MbRrZ
#serumresponsefactor #mitochondria #cardiacaging #oxidativestress #calciumhomeostasis #MAPK
📢New Recommended Reading📖 in GeroScience
Long-term dietary allyl isothiocyanate, a TRPA1 agonist, ameliorates cardiac fibrosis and diastolic dysfunction in aged mice by Chunqi Qian & @shuangtao et al.
https://t.co/iEevGKnCny
#TRPA1 #allylisothiocyanate #cardiacaging #diastolicdysfunction
Our study in @GeroScienceAGE found that allyl isothiocyanate (AITC)—a natural compound in wasabi and mustard—activates TRPA1 in sensory nerves, restoring vagal tone and slowing heart aging in mice. https://t.co/ghxaKUGeQw
@chaz_hong @MSUMD @MSU_Medicine @ScienceDaily @EurekAlert
Accelerated #CardiacAging during Space flight?😎
Evidence from 3D #HeartOnAChip with 30-day ISS travel😁
#hiPSC-#Cardiomyocyte in Hydrogel scaffold (decellularized pig myocardial matrix + reduced #GrapheneOxide)
6 mini-heart/PDMS post array enclosed in a flight chamber
4 chambers +giant magnetoresistive sensor (for contractility measurement) per plate habitat
CM space travel vs ground control
⏬contractile force
⏫beat interval
⏬sarcomere length
⏬Z-band width
⏫mitochondrial morpho-abnormality
+Bulk transcriptomics▶️
⏫Oxidative stress, Inflammation
Any evidence of DNA damage/genomic instability/senescence?😁
Deok-Ho Kim lab @PNASNews 2024 @devin_mair
https://t.co/Z9Vn6ErmGG
📢New Recommended Reading📖
Hyperactive mTORC1/4EBP1 signaling dysregulates proteostasis and accelerates cardiac aging by Weronika Zarzycka (@w_zarzycka) & Ying Ann Chiao et al.
https://t.co/Duh5e8BwEU
#cardiacaging #aging #4ebp1 #proteostasis
#CardiacAging #NonHumanPrimate🐵🫀
3x 4~6 y/o vs 3x 18~21 male #CynomolgusMonkey
snRNAseq Left Ventricle
#Cardiomyocyte most affected cell types by #Aging (Augur analysis)
Multiple Forkhead TFs FOXO3 FOXP1 FOXN2/3⏬in Aged #Cardiomyocyte
FOXP1 siRNA in hESC-derived cardiomyocyte▶️⏫#Hypertrophy #Senescence
What occurs to Aged Cardiac #Pericyte?
⏫Apelin signal; Non-integrin matrix interaction
⏬Circadian rhythm; Inositol signal; EGF signal; sodium homeostasis
⏬Communications with immune cells & cardiomyocyte
@Protein_Cell 2022
https://t.co/2cJfsfhtnQ
This review (PMID: 37274127) from Dr. Dao-Fu Dai et al. highlighted recent advances in the impact of the #mTORC1 pathway on organismal and cardiac aging. And discussed the interaction with mTOR complex 2 (mTORC2) and its potential role in #cardiacaging.
https://t.co/m6y1TVjObv
This review from Dr. Junjie Xiao et al. summarizes recent findings concerning metabolic changes during #cardiacaging and highlights the therapeutic approaches that target metabolic pathways in cardiac aging.
https://t.co/0aGN8h67ow
Review from Dr. Åsa B. Gustafsson et al. reviews the evidence demonstrating the #mitochondrial contribution to the #cardiacaging process and disease susceptibility, discussing the potential mechanisms for the age-related decline in mitochondrial function.
https://t.co/9mXJW5Ahmf
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