Top Tweets for #CheckMate8HW
🗨️ “This should be the standard frontline therapy for most patients with metastatic #ColorectalCancer and MSI-high disease.”
✍️ @BiachiTiago @MoffittNews discusses #CheckMate8HW, which showed benefits of #Opvido ➕ #Yervoy compared with #Opvido alone.
https://t.co/21JvRYmeaN
👀 Updated data from #CheckMate8HW show first-line #nivolumab ➕ #ipilimumab @bmsnews improves survival outcomes for #ColorectalCancer compared with nivolumab.
@sara_lonardi1 @iov_irccs and @GillSharlene @BCCancer discussed at #ESMO2025.
https://t.co/21JvRYmeaN
🤩@GillSharlene #esmoambassador @esmo #ESMO25 as the discussant for overview of the update of #checkmate8HW @Bristol and #ctDNA dynamics of #BREAKWATER @pfizer. #cancer #cancerresearch @OncoAlert
Update of #Checkmate8HW first-line subgroup for PFS with early overall OS results from @sarah_lonardi1 @esmo #ESMO25 #cancer #cancerresearch @bmsnews
#ESMOGI25 | Dr. Elena Élez shares insights with @ecancer on the #CheckMate8HW trial 🔬
🎯 This study compares nivolumab + ipilimumab versus nivolumab alone in patients with MSI-H/dMMR metastatic #ColorectalCancer.
Watch the video here 👇
https://t.co/amQRtF9CD6
🧬Spoiler alert: it’s important. Really important. And becomes more so this past year. #breakwater #checkmate8hw
How/when do you test? 🤔
Thanks @OncLive @marshalj23 for giving an excuse to chat and learn from each other 🙏
The Importance of Biomarker Testing in mCRC: @marshalj23, @mgfakih, @adasarimd, and @DrKatePedersen emphasize that upfront genomic profiling must include BRAF V600E status, RAS status, microsatellite instability (MSI) status, and fusion detection. https://t.co/8DqXunClWu via @onclive
#ASCO2025-Updated #CheckMate8HW Results: Nivolumab + Ipilimumab Shows Sustained PFS Benefit for MSI-H/dMMR Metastatic CRC https://t.co/kcU80N3wxW
3. #CheckMate8HW: Ph 3, dMMR/MSI-H unresectable or mCRC, Ipi (1mg/kg) + Nivo (240mg) Q3W - 4 cycles and then Nivo alone vs Nivo vs chemo
- mPFS 54.1 for Ipi/Nivo vs 5.9 mos with chemo
- Early drop off with Nivo alone (vs Ipi/Nivo)
- ORR: 71% (Ipi/Nivo) vs 58% (Nivo)
4/6
One page takeaway from #CheckMate8HW study that resulted in Ipi + Nivo @FDAOncology approval on April 8, 2025 for dMMR/MSI-H metastatic colorectal cancer. More data on MSI-H in adj at #ASCO25!
#OncTwitter #MedTwitter #gism @GIMedOnc
📍#CheckMate8HW confirma el beneficio de #Nivolumab+#Ipilimumab vs QT en #mCRC MSI-H/dMMR en 1L:
https://t.co/XmLqkM41d9
🔹Mediana de SLP no alcanzada vs. 5,9 meses con QT (p<0.001)
🔹SLP a 24 meses: 72% vs 14%
Happened this week: @FDA approves Nivo/Ipi vs. Nivo alone for #MSIhigh or #dMMR met #colorectal #cancer #Checkmate8HW
☑️Median PFS was NR in the combo arm vs. 39.3M (HR = 0.62 [95% CI: 0.48, 0.81]
☑️ORR = 71% vs. 58% (p-value 0.0011)
@bmsnews #CancerResearch #immunotherapy
![CathyEngMD's tweet photo. Happened this week: @FDA approves Nivo/Ipi vs. Nivo alone for #MSIhigh or #dMMR met #colorectal #cancer #Checkmate8HW
☑️Median PFS was NR in the combo arm vs. 39.3M (HR = 0.62 [95% CI: 0.48, 0.81]
☑️ORR = 71% vs. 58% (p-value 0.0011)
@bmsnews #CancerResearch #immunotherapy https://t.co/hAvHaXAiQv](https://pbs.twimg.com/media/GoWNJ8BX0AAF8q7.jpg)
Ipi/Nivo now @FDAOncology approved based off #Checkmate8HW: Ph 3, dMMR/MSI-H mCRC, Ipi (1mg/kg) + Nivo (240mg) Q3W for 4 cycles and then Nivo alone vs Nivo:
- mPFS NR for Ipi/Nivo vs 39·3 months
- ORR: 71% vs 58%
- Any grade AEs 81% from Ipi/Nivo vs 71% Nivo alone.
#OncTwitter
Background: Pembro > chemo in dMMR CRC (PFS benefit, numerical OS with crossover).
Dual checkpoint inhibitors (CPI) is better than chemo.
Is dual CPI better than Nivo?
#CheckMate8HW #GI25
New insights from #CheckMate8HW on #ColorectalCancer treatment are out in @TheLancet! Nivo IPI is better than Nivo alone in msi-high CRC in terms of PFS! Let's dive in. 🧵 #Oncology #Immunotherapy
#Gi25
https://t.co/msxEn8RbiO.
5. #Checkmate8HW: Ph 3, dMMR/MSI-H unresectable or mCRC, Ipi (1mg/kg) + Nivo (240mg) Q3W for 4 cycles and then Nivo alone vs Nivo:
- mPFS NR for Ipi/Nivo vs 39·3 months
- ORR: 71% vs 58%
- Any grade AEs 81% from Ipi/Nivo vs 71% Nivo alone. 3 Rx related deaths.
6/8
Long awaited practice-changing results from ph 3 CM8HW now out in @TheLancet. Nivo/ipi sign better than nivo mono in dMMR mCRC
@sara_lonardi1 @bmsnews #GI25
https://t.co/k3MKGriWPV
🔴 Una combinació d’immunoteràpia en primera línia millora els resultats clínics en pacients amb #CàncerColorectal metastàtic respecte a la quimioteràpia
🔬 Els resultats de l'assaig clínic de fase 3 #Checkmate8HW s'han publicat recentment a @NEJM 🗞️
➡️ https://t.co/5RtEgbdxbE
🔴 Una combinación de inmunoterapia en primera línea mejora los resultados clínicos en pacientes con #CáncerColorrectal metastático frente a la quimioterapia
🔬 Los resultados del ensayo clínico de fase 3 #Checkmate8HW se han publicado recientemente en @NEJM 🗞️
➡️ https://t.co/YbjccYpizx
🗞️ Recently published in @NEJM, the phase 3 open-label #CheckMate8HW results demonstrate that first-line immunotherapy combination improves outcomes in patients with metastatic #ColorectalCancer versus chemotherapy
➡️ https://t.co/FaZgmaC8Av
Una nueva combinación de inmunoterapia en primera línea muestra beneficios clínicos y mayor preservación de la calidad de vida que la quimioterapia en pacientes con un subtipo de #CáncerColorrectal metastásico.
➡️ https://t.co/IuoDYSBkMZ
#ESMOGI24 #Checkmate8HW
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