Top Tweets for #MSIhigh
#MSIhigh
#PD1
#本庶佑
#西川博嘉
#AshleyKiemen @AshleyKiemen
#北村哲@akirakitamura
#AlexZhavoronkov @biogerontology
#児玉裕三
https://t.co/21HlBDAbIa
Immunotherapy in Colon cancer 1
Immunotherapy is transforming outcomes in #MSIHigh #ColorectalCancer. Promising data from trials with #Nivolumab + #Ipilimumab and more. #Immunotherapy #CRC #Oncology #CancerResearch
Results of @NRGonc @SWOG #COMMITT trial #immunotherapy in combination with chemo in newly dx'd #MSIHigh met #colorectal #cancer
👉Median F/U 3.5yrs
👉PFS: 24.5 M vs. 5.3M; HR = 0.439, p= 0.0103
👉ORR: 86.1% vs. 46% (CR: 36.1 vs. 18.9%)
👉NS OS (HR= 1.04; p= 0.90; secondary)
@bmsnews #GI26 @asco @OncoAlert
Although #dostarlimab yields high responses in #dMMR LARC this paper reports 3️⃣ cases w/ progression on #IO; all #MSIHigh w/ high #TMB. #Transcriptomics showed #stromal-high profiles linked to worse #ICI response.
@susanebates @gbanna74 @PasRescigno
https://t.co/0sbE8k1s7j
When biology meets precision, dMMR cancer fades into absence 🪦💀☠️ @myESMO @ASCO #NICHE2 #dMMR #MSIHigh #ColonCancer #Immunotherapy #IO #GIOnc #CRC #CancerResearch #ESMO25 @OSUCCC_James
@JenSeligmann giving a wonderful lecture on "Optimizing IO therapy in #colorectal #cancer @myESMO #esmo2025 recognizing residual radiographic disease does not mean active disease. #MSIhigh #CancerResearch @OncoAlert
Neoadjuvant PD-1 blockade (dostarlimab):
✅ 100% cCR in dMMR rectal cancer
✅ 65% cCR in nonrectal dMMR (colon, HPB, urothelial)
✅ 92% 2-yr RFS, no missed surgery window
Organ preservation is real.
📄 https://t.co/QZveEWnpci
#GIoncology #HPBsurgeon #MSIhigh #SurgicalOncology
Heading to #ASCO25! Excited to connect with colleagues and share our upcoming submission on combining #immunotherapy and surgery for #msihigh #coloncancer patients with isolated peritoneal metastases—collaborating with @D_JafariMD & @AryehMetzger
#GIonc #ColorectalCancer #ASCO25
Happened this week: @FDA approves Nivo/Ipi vs. Nivo alone for #MSIhigh or #dMMR met #colorectal #cancer #Checkmate8HW
☑️Median PFS was NR in the combo arm vs. 39.3M (HR = 0.62 [95% CI: 0.48, 0.81]
☑️ORR = 71% vs. 58% (p-value 0.0011)
@bmsnews #CancerResearch #immunotherapy
![CathyEngMD's tweet photo. Happened this week: @FDA approves Nivo/Ipi vs. Nivo alone for #MSIhigh or #dMMR met #colorectal #cancer #Checkmate8HW
☑️Median PFS was NR in the combo arm vs. 39.3M (HR = 0.62 [95% CI: 0.48, 0.81]
☑️ORR = 71% vs. 58% (p-value 0.0011)
@bmsnews #CancerResearch #immunotherapy https://t.co/hAvHaXAiQv](https://pbs.twimg.com/media/GoWNJ8BX0AAF8q7.jpg)
Jackpot 🎰 and one of the highest TMBs I have seen, making this #cancer patient eligible for #immunotherapy. The power of ctDNA 💥 🧬 🩸 🧪 #MSIhigh #genomictesting #precisiononcology @capitalhealthnj @GuardantHealth @MassiveBio @ACSCAN @CancerXMoonshot
Microsatellite instability (MSI), also known as deficient mismatch repair (dMMR) should be tested at the time of colorectal cancer diagnosis. Learn more: https://t.co/PJCOB5RmLq
#KnowYourBiomarker #FastFacts #MSIhigh #MSI
Cancer patients receiving /considering #immunotherapy here is @sitcancer statement on #COVID19 #vaccination. #LynceSyndrome #MSIhigh @AliveAndKicknDD @HorganRoberta @manjuggm @fireflyann @CCAREfightlynch @CCAlliance @FightCRC @ColonCancerFdn
⚠️Just out! @sitcancer statement on #SARSCoV2 #vaccination & #Cancer #Immunotherapy
👉 https://t.co/ON6fdMFhVZ
#MedEd #MedTwitter #oncology #COVID19 #publichealth #advocacy #onctwitter #stayhome #WearAMask #AcademicTwitter
Congratulations @pashtoonkasi on your paper assessing #ctDNA for response to #IO in #MSIhigh patients.
🆕 Paper published today!
💡Can we use #liquidbiopsies to assess #immunotherapy response early❓
Not☝🏽but 2 ways:
1️⃣ #ctDNA kinetics VAF%
📈progression 🆚 response📉2-3 weeks into treatment!
2️⃣Plasma-#MSI; not tissue but🩸 MSI✔️➡️✖️💭
@OncoAlert @ASCO
https://t.co/bBG8Ipz0PW
@SyedAAhmad5 @Aiims1742 @agrothey @pashtoonkasi @EileenMOReilly @MPishvaian @mkatzmd @DenboJw @TheNotoriousHPB @DrJashDatta @TsengJennifer @sepideh_gholami @GIcancerDoc @Shrikhande_SV @ShaalanBeg @SWexner Biased towards #GI cancers. Fully agree with @pashtoonkasi re: Pembro in #MSIhigh tumors @Merck as being most pivotal in the past decade.
Patients with unresectable/metastatic #MSIhigh/#dMMR #ColorectalCancer now have their first frontline #immunotherapy option with the #FDA approval of #pembrolizumab:
https://t.co/PurIV5RPrS
#mcrc #crcsm #oncology #CancerNews
#CheckMate 142 immunotherapy (nivolumab+ipilimumab as 1L therapy show clinically meaningful benefit to #MSIhigh /#dMMR #mCRC patients by Dr. Heinz-Josef Lenz #GI20 @CCAlliance
Loss of function mutations in #PBAF part of the SWI/SNF complex might be the the new #Biomarker for positive response to #immune #checkpoint inhibitors and survival in #MSIhigh colorectal cancer patients - thank you, @sarahaboualaiwi #ASC019 #NationofAllies
From @sarahaboualaiwi Loss of function mutations in #PBAF part of the SWI/SNF complex maybe the the new #Biomarker for positive response to #immune #checkpoint inhibitors and survival in #MSIhigh #colorectalcancer patients #ASC019 @CCAlliance #NationofAllies
From @CathyEngMD tumor mutation burden in #ColorectalCancer maybe an additional indicator for response to immunotherapy separate then #MSIhigh #EAOCRC19 #Never2Young #Tomorrowcantwait @CCAlliance
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