Top Tweets for #Codebreak200
Results of the phase 3 #CodeBreak200 trail finds that sotorasib increased PFS compared with docetaxel in those with #KRASG12C+ advanced #NSCLC 💊🫁
Read the full study in @TheLancet by Adrianus Johannes de Langen, @LuisPaz_Ares and colleagues!
➡️ https://t.co/0dKfrCAfiV
My full video on #CodeBreak200 #sotorasib is out now
PFS of 1.1 month with 17%!!! early differential censoring
OS - null
I bet @FDAOncology will have to treat it as they did Quizartinib
https://t.co/uGpBdAVuBS
The Recent #Codebreak200 #Sotorasib #Lumikras
With 1.1 mo PFS, 0.0 mo OS, 15k a month
is a failure of Oncology
The trial is even worse than that
You won't believe it
It is not even a randomized trial
@FDAOncology may even veto it
Full video coming:
https://t.co/uGpBdAW2rq
🎆🚨Out in @TheLancet, the final primary analysis of ph3 #codebreak200: #sotorasib significantly improved PFS and QoL over docetaxel in #NSCLC patients pre-treated with chemo/IO; underpowered for OS. Humbled to have offered this option to our patients-kudos to all contributors
13) Note: #sotorasib is currently #approved 2L for #KRASG12C #LCSM, PFS benefit confirmed in #Codebreak200 @MLJohnson2! @OncoAlert @HemOncFellows @KRASKickers
🔽 Snippet of all single agent #KRASG12C data
Our new paper is out @VKprasadlab 2022 !
We analysed the confirmatory trial of sotorasib (1st KRAS inhibitor) in pts w/ lung cancer.
Are the data enough for REGULAR authorization? @Swissmedic_ @EMA_News @FDAOncology ?
Spoiler: WORSE survival not excluded w/ sotorasib ��
🧵👇
Check out these expert insights on #CodeBreaK200 🔍 from #ESMO2022, powered by Opus Strategy.
For further analysis and key takeaways, click here ➡️ https://t.co/eHR6v03zt1
#onctwitter #oncology #medtwitter #cancer
#Sotorasib #CPCNP #CodeBreak200 #CoberturaESMO2022 #ScienceLink
El resultado de supervivencia libre de progresión fue consistente en los subgrupos preespecificados.
https://t.co/twM3UtHdYz
@DrSteveMartin @Tony_Calles @myESMO #CodeBreak200 It is a dilemma. I definitely think the experience for most pts I have treated is better w #sotorasib vs docetaxel 2nd line but the survival advantage is not there. We need better KRASG12C drugs or combos. #lcsm #ESMO22
ESMO22 | @galetta2 su #CodeBreaK200: #sotorasib vs docetaxel nei pazienti con #NSCLC KRAS G12C
#lcsm @myESMO
3. #CodeBreak200: Ph 3, 2L NSCLC with mKRAS G12c, sotorasib vs docetaxel @MLJohnsonMD2
- 12mos PFS 24.8% vs. 10.1%
- mPFS was 5.6mos vs. 4.5 months
- No OS benefit but fewer Gr≥3 TRAEs w/ sotorasib
- Sotorasib was approved in May 2021.
5/9
Day 4 #ESMO22 Highlights from #CommunityOncologists perspective:
1. #IFCT1701 - ICI in mNSCLC
2. #POSEIDON Update - mNSCLC @MLJohnsonMD2
3. #CodeBreak200 - KRAS G12C NSCLC @MLJohnsonMD2
#LCSM #MedTwitter #OncEd @HemOncFellows @OncoAlert @myESMO
1/9
#CodeBreaK200 study for pts with #KRASG12C-mut platinum/IO pretreated #NSCLC
🎯Sotorasib (oral KRASG12C inhibitor) showed superiority over docetaxel!
✅1y-PFS: 24.8 vs 10.1% (HR=0.66; P=0.002)
✅ORR: 28.1 vs 13.2%
⬇️grade≥3 TRAEs
Congrats @MLJohnsonMD2 & team!
#ESMO22 @OncoAlert
#Sotorasib #CPCNP #CodeBreak200 #ScienceLink
Sotorasib demostró superioridad sobre la terapia estándar, docetaxel
https://t.co/KtyiRZpoSK
CODE-Breaking data via @Amgen press release
#CodeBreak200
Ph 3 sotorasib vs docetaxel in 2nd line setting met its PFS -primary endpoint
N=345
👉KrasG12C found in 13% of NSCLC
👉Universal #biomakertesting needed to identify pts early
#lcsm https://t.co/AJOJ71rSPY
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