Top Tweets for #Colcot
#SaveTheDate for the debate: interesting after the results of #ClearSynergy apparently in contrast with #Colcot and #LoDoCo studies ☀️ #EAS
In this controversy, Prof. Paul Ridker & Prof. Ulrich Laufs brilliantly review the state of the art regarding the challenges of treating inflammation to prevent ischemic cardiovascular complications. The aim of the discussion is to address the question: Is the current knowledge consistent enough to initiate such treatments in addition to the existing therapeutic tools? Learn more: https://t.co/VpxjTetgqY @ProfKausikRay @KatiOorni
Anti inflammatory treatment
in #STEMI did not show
promising results
in #CLEARSYNERGY
#TCT2024
Despite triple overall events
compared to #COLCOT
findings my be clouded by
multifactorial treatment
Still a lot to be learned …
The field of inflammation is more confusing than ever, and after CLEAR SYNERGY at #TCT2024, the confusion has reached a new level. The trial found that colchicine did not reduce major adverse cardiovascular events post-myocardial infarction, conflicting with earlier studies and meta-analyses that reported benefits. As if that weren't enough, colchicine was accompanied by an unpleasant side effect. This is somewhat embarrassing, given that the drug is FDA-approved and has a Class IIa recommendation in European guidelines for chronic coronary syndromes (but the new trial was essentially in STEMI).
It's easy to say "anti-inflammatory therapy", but several questions seek answers. First, is there a class effect? Absolutely not: methotrexate and glucocorticoids have not worked, colchicine has shown mixed results, and canakinumab has been effective in CANTOS. Moreover, is it a drug for acute or chronic coronary syndromes? One would expect a greater effect in acute settings, but inflammation also plays a protective role in that context, and this new trial is clearly a step backward. Colchicine is a somewhat rudimentary drug: it interferes with inflammasome formation, but this is a very preliminary step in the inflammation pathway. Canakinumab acts on IL-1, but only patients who can also suppress IL-6 formation show a prognostic benefit.
Ziltivekimab is a monoclonal antibody that antagonizes IL-6. We are conducting the ARTEMIS study to understand more, and the results of CLEAR SYNERGY make the outcomes of this study even more important for clarifying the role of inflammation in acute coronary syndromes and whether antagonizing it brings prognostic benefits.
#TCT2024 results of #CLEARSynergy : after #COLCOT and #LoDoCo , is there still a place for #Colchicine in post #ACS ? https://t.co/B8o3znL1fJ
#LateBreaking trial 🔥 #CLEAR
#Colchicine 💊may NOT be effective in #STEMI and large #NSTEMI with no difference found in outcomes! 💔
Largest Colchicine trial with over 7000 patients 👏 #COLCOT #LODOCO2 #CHANCE3 #CONVINCE
#TCT2024 @crfheart @TCTConference @TCTConference 🫀
Tomorrow - free open day at Everyone’s Garden in Colcot
https://t.co/z6Xx3DFWPn
#colcot #freeevent #barry #glamorganstar
💥📜 Read our paper on #Colchicine in #CVD🫀& #atherosclerosis
#COLCOT #LoDoCo & #LoDoCo2 ➡️significant🫀benefit & #FDA approval in #2023 for CVD
More to come #Colchicine from our group..
@HarborUCLA @NCHRooneyHeart @BudoffMd @JairoaldanaMD @JonathonLeipsic @FloridaACC #yesCCT
_FDA approves #Colchicine to ⬇️risk of MI ,stroke,coronary revascularization, & CV ☠️ in adult patient with established atherosclerotic disease or with multiple risk factors for CV disease.
_0.5mg daily recommended , _hsCRP> 2mg/dL starting point
#LoDoCo2 , #COLCOT 1/2
Programme du jour avant le match de tout à l'heure au stade de Ngoa Ekelle.
@FecafootOfficie #MTNEliteOne #Matchday #COLCOT #NgoaEkelle
🔬 Are you aware of the causal relationship between inflammation and cardiovascular disease? Discover more about #CVD in the #COLCOT trial with @jctardif_mhi here! 👉 https://t.co/YCJM22D9yg
#CardioTwitter #MedEd #Atherosclerosis
Thank you @sangeet @wisekids for delivering a Digital Well-being Workshop for @PWLLCAVC1 students. @CAVC #Wellbeing #colcot
#COLCOT and cost-effectiveness: adding colchicine after #myocardial #infarction as an effective and even cost-saving strategy: https://t.co/PXHrY03cgf
@cpgale3 @diogoasantosfer #EHJQCCO #cardiotwitter
@dr_bavlos Not yet also for me but you have an ongoing trial (CLEAR-synergy) evaluating the combination spironolactone/colchicine vs placebo. And you have a net clinical benefit in #COLCOT @AngoulvantD with no more news of colcovid 😎
#WeekendLecture
#SecondaryPrevention
Inflammation as🎯?
Targeting IL-1β #canakinumab ⏬CV events, independent of lipid-level lowering #CANTOS
#Colchicine⏬CV events, including #stroke #COLCOT, & #CONVINCE trial is evaluating this effect on nonCE stroke https://t.co/bGWIzaLYGk
Enjoyed talking to our Cardiovascular Sciences iBSc students this morning about inflammation and CVD covering #CANTOS #CIRT & #COLCOT and why #IL6 may be the next big target @UCL_ICS @ADHingorani @DanielSwerdlow
@drakchaurasia @monarchdiaries @DrToddLee @drpablocorral @__ice9 @PawanKu71851950 @ethanjweiss @colcovidtrial @joex92_ @farid__jalali @drrobinCCM @julienpotet @nyulangone @NYULH_TechHub @NYULangoneBK @BinitaShahMD @DrEmilyMcD I am a layman but since colchicine was used in #ColCot trial, I was expecting it to be beneficial to heart
Seeing increased clot result is a bummer
@abledoc
https://t.co/f9ybeVy0qM
La colchicine n’est pas le remède miracle vanté par des chercheurs montréalais – RCI | Français https://t.co/o3SPRqzuvs
Watch Dr. Jean-Claude Tardif and Dr. Shaun Goodman discuss the #COLCOT trial in #Colchicine: Emerging Data and Impact on Clinical Practice. The video is available to watch on-demand at 🔗https://t.co/jsMFse0Rfk #CardioTwitter
@RyanMarino @schneiderleonid @laxswamy
narrow therapeutic index
dose range is very narrow
#LoDoCo & #ColCot trials established acceptable low dose of Colchicine for heart problems @drrobinCCM
Also interactions with other medicines (such as Ivermectin) can create toxicity, I think
https://t.co/Iv9PKmNRCm
@laxswamy I am not sure there is an organ that colchicine won't shut down in an overdose.
The #COLCORONA study shows that #colchicine can effectively treat #COVID19 patients. Congratulations to @jctardif_mhi and team from @ICMtl Adding these findings to the ones from #COLCOT, we must ask ourselves if #colchicine should be added to the drinking water
#COLCORONA #Clinicaltrial show that #colchicine is the only effective oral medication for treating non-hospitalized patients with #COVID19.
#Covid_19 #clinicaltrials #coronavirus #clinicalresearch
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