Top Tweets for #Enlicitide
The Largest Small molecule: Manufacturing Process for #Enlicitide https://t.co/H68myAzo27 David Thaisrivongs, Executive Director and Head of Biocatalysis at Merck, will present the development of enlicitide decanoate (MK-0616), a novel orally bioavailable macrocyclic peptide
#enclicitide is a Macrocyclic peptide. Why cyclic? That is due to the fact linear peptide must be injected. Cyclic peptide can be taken orally due to enhanced conformational rigidity, metabolic stability. more cyclic peptides in the pipeline for sure. https://t.co/jjwysqpu6q
The @US_FDA has approved #Lipfendra (#enlicitide), an oral PCSK9 inhibitor, expanding treatment options for adults with #hypercholesterolemia who require #LDL-C lowering.
https://t.co/FNB8y6MgPI
@Merck
Enlicitide को अमेरिका में मंजूरी, कितना प्रभावी है ये दवा?
https://t.co/2rRKsfRiCU
@rajulkumarjha1 @DrGodseRavi1
#Enlicitide #BadCholesterol #LDLCholesterol #CholesterolMedicine #HeartDisease #HeartAttack
స్టాటిన్ పడదా? ఇంజెక్షన్ వద్దా? కొత్త కొలెస్ట్రాల్ టాబ్లెట్ వచ్చింది! | Dr M S S Mukharjee
#Lipfendra #Enlicitide #PCSK9 #Cholesterol #LDL #HeartHealth #Statin #Cardiology #drmssmukharjee Dr M S S Mukharjee is a Senior Interventional Cardiologist and Managing Director of Pulse Heart Super Speciality Hospital, Miyapur, Hyderabad. Through this channel, he shares clear, evidence-based health information to help people understand their bodies, prevent disease, and make better health decisions. You will find videos on heart health, cholesterol, blood pressure, diabetes, lifestyle, prevention, medical myths, new research explained in simple language, and practical advice for everyday life. Complex medical topics are broken down so that anyone can understand and apply them. This channel is built on a simple belief: informed patients live longer and healthier lives. Whether you are a patient, a caregiver, a medical student, or someone who wants to stay healthy, this space is for you.
🫀FDA Approves Merck's #LIPFENDRA® (#Enlicitide)
✅ First and only once-daily oral PCSK9 inhibitor approved by the U.S. FDA for lowering LDL-C.
Indications:
• Primary hypercholesterolemia
• Heterozygous familial hypercholesterolemia (#HeFH)
FDA approves Lipfendra® (enlicitide) — 1st oral PCSK9 inhibitor.
CORALreef Phase 3: ~56-59% LDL-C reduction, ~50% ApoB reduction. No more injections. CV outcomes trial still ongoing — biomarker efficacy proven.
#Lipfendra #Enlicitide #PCSK9 #AdvancedLipidPanel #ApoB #LipoproteinA
Now got #FDA approved. 😊😍
#Lipfendra (#enlicitide), oral PCSK9 inhibitor.
Very good news for those with resistant hypercholesterolemia who don’t like injections. 😁💉
In the phase 3 CORALreef Lipids trial, the oral PCSK9 inhibitor enlicitide reduced LDL cholesterol by 57% at 24 weeks and also lowered non-HDL cholesterol, apolipoprotein B, and lipoprotein(a). Adverse events were similar in the two groups. Full trial results: https://t.co/o5RS02KCWi
Editorial: Exploring a New “Reef” in Dyslipidemic Risk Reduction https://t.co/W3KfZHkxMD
#enlicitide ( an oral PCSK9 inhibitor) The first I do is to review Package insert under Description. It is a macrocyclic peptide with lousy solubility. MW 1722 so Merck added sodium caparte to facilitate absorption (1% oral bioavailability) did you see carboximide grs (9)?
The FDA has approved enlicitide, the first oral PCSK9 inhibitor (approval was based on data from CORALreef HeFH and CORALreef Lipids). https://t.co/hGl1dbvUVF
💊 No injections. Just one pill.
#Enlicitide, the first oral #PCSK9 inhibitor, reduced LDL-C by up to ~70% when added to high-intensity statins, bringing potent #cholesterol lowering into a new era.
A major step forward for #cardiovascular prevention.
#Cardiology #Prevention
Breaking News: The FDA approved a daily pill that can lower cholesterol levels far below what statins can, clinical trials have shown. https://t.co/dTUtOXn4Wk
Merck’s #Lipfendra (#enlicitide) now the first #oral #PCSK9i, for adults w/ #hypercholesterolemia (incl. #HeFH). Ph3: 56–59% #LDL-C reduction vs PCB @ 24 wks. PO alternative to injectable PCSK9s, though dosing requires 8hr #fasting + 30 min post-dose fasting. #CVOT ongoing.
LIPFENDRA (#enlicitide) is a once-daily prescription pill that has been approved by the @US_FDA . It is the first oral #PCSK9 inhibitor designed to lower bad cholesterol (LDL-C)
#LDLc #PCSK9i
Investigational daily pill lowered bad cholesterol as much as injectables
#Enlicitide, designed to deliver antibody-like efficacy, has the potential to be the first approved oral #PCSK9i to lower #LDL-C with a safety profile comparable to placebo
https://t.co/J7RVEkG1Oe
#AHA25 @AHAScience
PCSK9 pharmacology is getting crowded (in the best possible way)
In CORALreef AddOn, oral #enlicitide reduced LDL-C, ApoB & non-HDL-C vs oral non-statin comparators
🔗 https://t.co/tr95xt9WIX
🔜 at #EASCongress2026, Prof. @AL_Catapano focuses on ApoB in phase 3 trials #MyEAS2026
#EASCongress2026 @society_eas
Ioanna Ghouni-Berthold shows ongoing outcome studies with the new oral #PCSK9 inhibitors #Enlicitide and #Larovprostat, both expected to be completed by 2029. Strong emotions underway!
Prof Alberico Catapano @AL_Catapano, discusses #Enlicitide and its potential to close gaps in lipid management by rapidly lowering #LDLC in patients on statins not achieving their #cholesterol goals > https://t.co/APn99IsVJQ
#PCSK9 #cardiology #HeFH #hypercholesterolemia #MK0616
#Enlicitide may be an important add-on treatment for #ASCVD and high-risk patients who need lipid lowering beyond statins, suggest new results presented at #ACC26 from the CORALreef AddOn trial. Find out more at @PCSK9Forum >> https://t.co/JAvGYVLF72
#JACC #cardiology #PCSK9
From #ACC2026 - Oral PCSK9 inhibitor #enlicitide offers significantly greater reductions in low-density lipoprotein #cholesterol levels than other nonstatin therapies when added to first-line statins.
👉 https://t.co/ZBHMskCOXV
#MedNews
Outstanding program with @AnnMarieNavar and Mark Sabatine. Newest data from Vesalius on #PKSK9i with #evolocumab, new data on #enlicitide and discussion of the new #lipid guidelines and how to implement
Shoutout to Drs. Ballantyne (@CBallantyneMD), Navar (@AnnMarieNavar), and Sabatine for leading an amazing discussion at #ACC2026! Real-world takeaways for real-world care.
📺 Replay available here: https://t.co/SYRrOAd5n8
Thanks to @Merck for their grant support and @MendedHearts for collaborating with us! #CME #MedEd
⏬64,6% LDL ⏬26,2%LPa ⏬54,6% ApoB 🚀🚀🚀 Efficacy and Safety of #Enlicitide, an Oral Inhibitor of PCSK9, Compared With Bempedoic Acid and Ezetimibe in Statin-Treated Adults With Hypercholesterolemia: Phase 3 #CORALreef AddOn Trial #ACC26
Cholesterol: हार्ट अटैक का खतरा होगा कम, आ रहा है Enlicitide
https://t.co/lKph55fWWp
@rajulkumarjha1
@DrGodseRavi1
#Statins #LDL_cholesterol #LDL #cholesterol #HeartAttack #PCSK9i #Enlicitide #Enlicitide_pill #Enlicitide
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