Top Tweets for #GeneticInteractions
📊Structural Snapshot📊
Integrative structure determination of histones H3 and H4 using genetic interactions
✏️ By @ig_ech, @HannesBraberg, @salilab_ucsf @KroganLab from @UofCalifornia
🔗 https://t.co/VWpmTE2cK3
#geneticinteractions #integrativestructuremodeling
I’m excited to share our pre-print for an accessible #RStats package named GRETA that queries @CancerDepMap data to identify candidate #GeneticInteractions and essentiality networks in cancer cell lines.
https://t.co/f1xHGCo17E
#SyntheticLethality #GeneticScreens
1/2
GRETA: an R package for mapping in silico genetic interaction and essentiality networks https://t.co/jHgYwnhN96 #bioRxiv
Authors proposed a new #computationalapproach for improved precision in #Geneticinteractions(GI) identification by applying constraints that consider actual #biologicalphenomena. Read more here: https://t.co/ksvyMNS0br
#molecularnetworks
#refiningprocess
#cancertherapeutics
Excellent new work from @dekegelb @Boiley and @colmr in @CellSystemsCP "Comprehensive prediction of robust synthetic lethality between paralog pairs in cancer cell lines". #cancer #CRISPR #geneticinteractions #precisionmedicine
https://t.co/TBixPoBIww
Very excited to establish my own lab as a tenure-track Stadtman Investigator at the Molecular Targets Program @NCIResearchCtr @NIH. Recruiting PostDocs and PostBac students interested in #GeneticInteractions #CancerMetabolism #CRISPR #FunctionalGenomics
https://t.co/SrBrSHDj0K
Natural genetic variants frequently suppress deleterious mutations --> https://t.co/leoS05Q7jG @jsvanleeuwen @unil @LeopoldParts @sangerinstitute #GeneticInteractions
Systematic analysis of bypass suppressor mutations that can overcome the lethality of essential gene deletions in yeast --> https://t.co/UY0ID4cuxT from C Boone & B Andrews labs @DonnellyCentre @UofT & @jsvanleeuwen @unil #GeneEssentiality #GeneticInteractions
Check out our new study for the systematic mapping of #GeneticInteractions for de novo #FattyAcid synthesis using #CRISPR screens
@NatMetabolism @Lawson6Keith @maxbillmann Moffat, Boone, Andrews, Myers, @gingraslab1 @DonnellyCentre @UofT @UMNComputerSci
https://t.co/XmHJ3GoaoX
great to see this wonderful review on #geneticinteractions published today in @CellCellPress from @DonnellyCentre @UofT researchers 🇨🇦
How do we get from genotype to phenotype? We need to understand fundamental principles of gene interactions and #networks, covered in this @cellcellpress review from Charlie Boone, Brenda Andrews & Michael Costanzo @UofT https://t.co/lTz77PnQ9u #genetics #backtobasics
#Geneticinteractions between ABA signalling and the Arg/N-end rule pathway during #Arabidopsis seedling establishment https://t.co/sMl2IwGr3h
#Geneticinteractions between ABA signalling and the Arg/N-end rule pathway during #Arabidopsis seedling establishment https://t.co/LG3MC5D5Lr
#Geneticinteractions between ABA signalling and the Arg/N-end rule pathway during #Arabidopsis seedling establishment https://t.co/bAUml7UElK
Huge new Resource in @CellCellPress from Jonathan Weissman @jswtweeter, Luke Gilbert & co @UCSF : a large scale genetic interaction map in human cells #functionalgenomics #geneticinteractions #CRISPR #CRISPRi #drugtargets #cancer https://t.co/nGNZjaFiwU
Large scale genetic interactions in human with double CRISPRi (472×472 genes x2 cell lines). Besides basic biology findings this has useful applications for design of drug targets in cancer (second hit for LoF) https://t.co/r6fLeNcHx3
05/2018 Issue: measuring condition-dependent #GeneticInteractions, discovering drug-sensitive pathways in #sepsis, expression variation in signalling control --> https://t.co/9ctugb5kyh
Cover: High-throughput discovery of functional disordered regions (Madan Babu's lab @MRC_LMB)
Barcode Fusion Genetics to Map Genetic Interactions (BFG‐GI): new method for measuring condition‐dependent #GeneticInteractions en masse. Here, applied to #DNARepair genes --> https://t.co/yqGpckGNAE
@FPRoth @DonnellyCentre @UofT #MSBmethod #NetworkBiology
Toward an integrated map of genetic interactions in cancer cells (OA) https://t.co/nmYQr4pz57 by @Boutroslab - #geneticInteractions #geneInteractions #interactome #syntheticLethality #syntheticLethal #CRISPR
Systematic analysis of complex genetic interactions ($):
* constructed 200K yeast triple mutants, scored negative trigenic interactions
* global trigenic network is 100X > digenic network, links distant bioprocesses
* implications for variant interpretation
#geneticInteractions https://t.co/K5Ei2ITXe6
Ramsay Bowden: treating disease caused by mutation in gene A by replacing gene A not always possible. Sometimes can treat by knocking out gene B instead. #geneticinteractions #grd18
@ElementoLab @Coryandar @neelmadhukar, finally #CRISPRCas9 screens to map #GeneticInteractions in human #cancer cells. Let's work on this! https://t.co/6a1OCHi11x
Integrating multiple #CRISPRCas9 screens to map genetic interactions in human cells --> https://t.co/9zGrERFIxf @Michael_Boutros @Boutroslab @DKFZ
Quan Zhong: we turn to our favorite organism, #yeast, great #modelOrganism in which to detect #geneticInteractions #TAGC16
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