Top Tweets for #GermlineTesting
#Universal #GermlineTesting (UGT) is feasible, #costeffective, clinically impactful...enhances #precision #breastcancer care & supports #personalized #prevention strategies.
#UGT should be...considered as a standard component of #personalized #breastcancer care in the era of #precisiononcology.
c/w https://t.co/CNac7Ra4tl @beitsch et al. @JCO_ASCO
https://t.co/hVYDGUHgbt @WhitworthMD et al. @JAMANetworkOpen
https://t.co/L54aNVQePS @EdEsplin et al. @JCOPO_ASCO
https://t.co/wa8YmWUWs3 @VivekSubbiah @Dr_R_Kurzrock @JCO_ASCO @ASCO
#access #reducedisparities #precisionmedicine #precisiontherapy #clinicaltrials #precisionprevention
https://t.co/2g0fA3DDyM #TessHuy et al. #CurrentBreastCancerReports @SpringerNature
Retrospective analysis reveals germline testing uptake and referral patterns for pancreatic adenocarcinoma across one health district. Clinical findings show variable impact on management. #PancreaticCancer #GermlineTesting 1/4
#Germlinetesting is underutilized & varies by #cancer diagnosis
~29% of #patients w/ PVs (#breastcancer & #GIcancer) reported no relative tested
~18.3% reported >=4 relatives were tested
...more attention is needed to address...#restrictive &...conflicting testing #guidelines....(at-risk) relatives' #genetictesting rates remain too low.
c/w https://t.co/C2PVcJ9GO9 @AllisonKurian et al. @JAMA_current
#access #reducedisparities #precisionmedicine #precisiontherapy #clinicaltrials #precisionprevention #cascadetesting
https://t.co/gMmbtORM6W @AllisonKurian @Stanford #StevenKatz @UMich et al. @JCOPO_ASCO @ASCO
50% of #patients [w/ #cancer] positive for #germline variants did not meet @NCCN testing criteria, in a #PrecisionMedicine clinic providing #universal #germlinetesting to all #patients w/ common & rare #cancers
15% of all #patients had #pathogenic #germline #variants (PGVs)
13% of #patients w/ common #cancers (inc #breastcancer #lungcancer #CRC #pancreaticcancer #prostatecancer)
17% of #patients w/ rare #cancers (inc #sarcoma #braincancer #cholangiocarcinoma)
c/w
https://t.co/lNN20PNtb1 #PiperNicolosi et al. @JAMAOnc
https://t.co/yXJwrly1RU @beitsch et al. @JCO_ASCO
https://t.co/Ys7GqQ5FYk #NealShore et al. @JCOOP_ASCO
https://t.co/hVYDGUHgbt @WhitworthMD et al. @JAMANetworkOpen
https://t.co/SZKtSENn94 @J_Samadder et al. @JAMAOnc
https://t.co/79KmVe0Ame #IsaacAilts et al. @MDPIOpenAccess
https://t.co/wa8YmWUWs3 @VivekSubbiah @Dr_R_Kurzrock @JCO_ASCO
Overall, our data support #universal [#pancancer] #germlinetesting as a strategy to uncover clinically valuable information...including...#medical management, #targeted #treatment...
#access #reducedisparities #genetictesting #precisionmedicine #precisiontherapy #clinicaltrials #precisionprevention
https://t.co/GDtC0p3yb0 #PhebeLemert @Dr_R_Kurzrock et al. @MedicalCollege @JCOOA_ASCO @ASCO
![EdEsplin's tweet photo. 50% of #patients [w/ #cancer] positive for #germline variants did not meet @NCCN testing criteria, in a #PrecisionMedicine clinic providing #universal #germlinetesting to all #patients w/ common & rare #cancers
15% of all #patients had #pathogenic #germline #variants (PGVs)
13% of #patients w/ common #cancers (inc #breastcancer #lungcancer #CRC #pancreaticcancer #prostatecancer)
17% of #patients w/ rare #cancers (inc #sarcoma #braincancer #cholangiocarcinoma)
c/w
https://t.co/lNN20PNtb1 #PiperNicolosi et al. @JAMAOnc
https://t.co/yXJwrly1RU @beitsch et al. @JCO_ASCO
https://t.co/Ys7GqQ5FYk #NealShore et al. @JCOOP_ASCO
https://t.co/hVYDGUHgbt @WhitworthMD et al. @JAMANetworkOpen
https://t.co/SZKtSENn94 @J_Samadder et al. @JAMAOnc
https://t.co/79KmVe0Ame #IsaacAilts et al. @MDPIOpenAccess
https://t.co/wa8YmWUWs3 @VivekSubbiah @Dr_R_Kurzrock @JCO_ASCO
Overall, our data support #universal [#pancancer] #germlinetesting as a strategy to uncover clinically valuable information...including...#medical management, #targeted #treatment...
#access #reducedisparities #genetictesting #precisionmedicine #precisiontherapy #clinicaltrials #precisionprevention
https://t.co/GDtC0p3yb0 #PhebeLemert @Dr_R_Kurzrock et al. @MedicalCollege @JCOOA_ASCO @ASCO](https://pbs.twimg.com/media/HJ72g9MakAExdLx.jpg)
...multi-gene panels (#germlinetesting) have emerged as the standard of care for inherited #cardiac conditions (e.g. #cardiomyopathies, etc.)...contributing to...#prognostic assessment, & personalized #therapeutic decision-making...
cit. 'Comprehensive #GeneticTesting for #Pediatric #HypertrophicCardiomyopathy' https://t.co/zGnHWOmfDt #DrDanaGal et al. @Stanford @SpringerNature
#Universal #germline #genetictesting for all #patients w/ #cardiomyopathy
#access #reducedisparities #precisionmedicine #precisiontherapy #clinicaltrials #precisionprevention
https://t.co/zE13nWBDJF #KonstantinosAgiannitopoulos et al. @Life_MDPI @MDPIOpenAccess
#Genetictesting remains markedly underutilized across #urologiccancers in the United States, w/
only approximately 10% of eligible #patients undergoing testing within one year of diagnosis.
Among 125,860 #patients w/ urologic cancers meeting criteria for #germlinetesting, % tested (100% eligible)
#kidneycancer 9%
#adrenalcancer 8%
#uppertracturothelialcancer (UTUC) 16%
#bladdercancer 8%
#prostatecancer 10%
...higher proportion of Black men did not undergo #genetictesting for #prostatecancer, 14% vs 21%
"the actual rates of #genetictesting may be lower than that observed in our study"
c/w #PROCLAIM https://t.co/h66HdRztVj #DrNealShore et al. @EurUrolOncol
'#Universal #Germline #GeneticTesting Standard of Care for #Patients W/ #ProstateCancer: The Time Is Now' #DrNealShore et al. @JCOOP_ASCO https://t.co/1FACP4K8cJ
'#Universal #Germline & #Tumor #GenomicTesting Needed to Win the War Against #Cancer' https://t.co/wa8YmWUWs3 @VivekSubbiah @Dr_R_Kurzrock
#access #reducedisparities #precisionmedicine #precisiontherapy #clinicaltrials #precisionprevention @neerajaiims
https://t.co/7aT17UtELI #SriSaranManivasagam & #JayDRaman @urogoldjournal
#Germline #genetictesting improves #overallsurvival (OS) in #patients w/ #pancreaticcancer
5yr OS in #patients w/ #germlinetesting 12%
5yr OS in #patients w/o #germlinetesting 1.8%
Of those #patients w/ #germlinetesting Pathogenic Germline Variants (PGVs), 7 treated w/ #olaparib (#BRCA1/2), 1 treated w/ #pembrolizumab (#MSH6)
OS for #patients w/ PGVs on #targetedtherapy was significantly improved vs #patients w/ PGVs who received standard-of-care therapy (HF, 0.09)
c/w https://t.co/KJnQj5szfn @PedroUson et al. @ACG_CTG
#Universal #germlinetesting in all #patients w/ #pancreaticcancer
c/w https://t.co/wa8YmWUWs3
@VivekSubbiah @Dr_R_Kurzrock @JCO_ASCO
#access #reducedisparities #precisionmedicine #precisiontherapy #clinicaltrials #precisionprevention
https://t.co/l2FPkw0q9M #ThomasOConnor et al. @JCOPO_ASCO @ASCO
>23% of #patients w/ #pancreatobiliary #ampullarycancer had PGVs in homologous recombination (HR) pathway genes alone (#BRCA1, #BRCA2, #PALB2, #ATM) w/ #germline #genetictesting
"Our findings reinforce #clinicalguidelines supporting #germlinetesting in #ampullarycancer to inform both HR-directed therapies and #immunotherapy"
One more reason for #universal #germlinetesting in all #patients w/ #cancer
c/w
https://t.co/tFSemI4b2i @EdEsplin et al. @JCOPO_ASCO
https://t.co/wa8YmWUWs3 @VivekSubbiah @Dr_R_Kurzrock @JCO_ASCO @ASCO
#access #reducedisparities #precisionmedicine #precisiontherapy #clinicaltrials #precisionprevention
https://t.co/HIysKa6Eb5 #MaksymMisyura et al. @JCOPO_ASCO
Comprehensive combined #germlinetesting & #somatictesting in #patients w/ 33 types of #cancer found:
100% of #patients positive for an actionable #germline variant (#PGx)
42% were positive for an actionable #somatic variant matched to a #precisiontherapy
8% were positive for a pathogenic #germline cancer predisposition variant (PGV) in the same cohort (https://t.co/iCTgYNepOm)
#PGx, one more reason #Universal combined #germline & #somatic #sequencing in #oncology should be implemented to enhance #therapeutic precision, minimize #adverse effects, & inform #individualized treatment decisions.
c/w
https://t.co/tFSemI4b2i @EdEsplin et al. @JCOPO_ASCO
https://t.co/wa8YmWUWs3 @VivekSubbiah @Dr_R_Kurzrock @JCO_ASCO
#access #reducedisparities #precisionmedicine #clinicaltrials #precisionprevention
https://t.co/pPULo5Yq8P #VaiPathak et al. @JCOPO_ASCO @ASCO
...need for routine (#universal) #germlinetesting in #patients w/ Upper Tract #UrothelialCancer/#UTUC & consideration of broader testing across #urothelialcancer.
As...#Lynchsyndrome is common in #patients w/ #UTUC; yet, many carriers present w/ #bladdercancer alone.
20% of #patients w/ #UTUC had PGVs on #germline #genetictesting, 46% of these w/ PGVs c/w #Lynchsyndrome, 42% of these w/ PGVs in HRR genes
c/w
https://t.co/hnQ3qZQjSb @AminNassarMD et al. @GIMJournal @TheACMG
https://t.co/RtjMMy1uET @MouneebC et al. @JUrology @AmerUrological
#access #reducedisparities #precisionmedicine #precisiontherapy #clinicaltrials #precisionprevention @CGAIGC
https://t.co/aCdLaSK8VS #DrStevenMonda et al. @EurUrolOpen
#Germline mutations in #NSCLC carry important prognostic, predictive, and preventive implications. Systematic #germlinetesting in selected #patients, could guide #precisiononcology, enable #targetedtreatments...
c/w
https://t.co/n2gtyTscA5 #DrStevenSorscher et al. @JCOPO_ASCO
https://t.co/wa8YmWUWs3 @VivekSubbiah @Dr_R_Kurzrock @JCO_ASCO @ASCO
#access #reducedisparities #universal #genetictesting #lungcancer #precisionmedicine #precisiontherapy #clinicaltrials #precisionprevention
https://t.co/Ipkqim4bko #DrGabriellaGentile et al. @CHematology
...these results justify multigene panel #germlinetesting as the initial step for all #patients w/ early-onset #colorectalcancer (#EOCRC), including #universal #genetictesting.
To translate into tangible clinical benefit, the obligatory implementation of #universal #genomicscreening for all #patients w/ #EOCRC would be recommended to reliably identify overlooked high-risk individuals and initiate timely #preventive interventions.
c/w
https://t.co/tFSemI4b2i @JCOPO_ASCO
https://t.co/TiP2mDeYEN #DrSarahCoughlin et al. @JCOPO_ASCO
https://t.co/c9fETqaT0X @J_Samadder et al. @JAMAOnc
https://t.co/e5EtRqgwUT @PedroUson @AGA_CGH
https://t.co/wa8YmWUWs3 @VivekSubbiah @Dr_R_Kurzrock @JCO_ASCO @ASCO
#access #reducedisparities #precisionmedicine #precisiontherapy #clinicaltrials #precisionprevention #colorectalcancerawarenessmonth #CRC @CGAIGC
https://t.co/SxvwARuS4C #KenjiFujiyoshi #InternationalJournalofClinicalOncology @SpringerNature
[#Germline #genetictesting] rates [in #patients w/ #breastcancer] in the US remain #suboptimal relative to practice guideline recommendations (@ASBrS) & the availability of adjuvant targeted #therapy.
...areas of unmet need include [#germlinetesting] for more #patients w/ HER2(-) early-stage #breastcancer, e.g w/ HR+ disease & including #patients >50 yo.
...improvements are needed in testing timelines by implementing #genetictesting before surgery to guide surgical & systemic therapy decision-making
#Universal #germline #genetictesting for the #precisiontreatment of all #patients w/ #breastcancer
c/w
https://t.co/yXJwrly1RU @beitsch et al. @JCO_ASCO @ASCO
https://t.co/wa8YmWUWs3 @VivekSubbiah @Dr_R_Kurzrock @JCO_ASCO
#access #reducedisparities #precisionmedicine #clinicaltrials #precisionprevention
https://t.co/tEFPAFJZTt #KathrynMishkin et al. @FrontOncology
Embedded and full mainstream #GermlineTesting models for patients with #MetastaticProstateCancer in the VA improved effectiveness, efficiency, and timeliness compared with the traditional genetic consultation approach.
https://t.co/2mF2MPZXA3
6% of #patients w/ #DCIS had PGVs on #germline #genetictesting inc. #ATM #BRCA2 #PALB2 #CHEK2
Study supports continued #genetictesting of #patients w/ #DCIS (& all #patients w/ #breastcancer) c/w @ASBrS guidelines
i.e. #Universal #germlinetesting of #patients w/ #breastcancer
c/w
https://t.co/CNac7Ra4tl @beitsch et al. @JCO_ASCO
https://t.co/hVYDGUHgbt @WhitworthMD et al. @JAMANetworkOpen
https://t.co/wa8YmWUWs3 @VivekSubbiah @Dr_R_Kurzrock @JCO_ASCO @ASCO
#access #reducedisparities #precisionmedicine #precisiontherapy #clinicaltrials #precisionprevention
https://t.co/1Cd5AIOJmt #DrJessicaDzubnar et al. @AnnSurgOncol
5.4% of #patients w/ #GI cancers had PGVs on #germlinetesting, inc #colorectalcancer/#CRC, #livercancer (HCC), #gastriccancer (GC), #pancreaticcancer (PC), #esophagealcancer (EC), & #cholangiocarcinoma (CCA)
84.2% had PGVs in DNA-damage respone pathway (#DDR) genes
"...highlights potential avenues for precision interventionsβsuch as #PARP inhibitors for HRR-deficient tumors and immunotherapy for MMR-deficient subtypes..."
c/w
https://t.co/TRA0Fgslz4 #CRC @PedroUson et al. @MayoClinic @AGA_CGH @AmerGastroAssn
https://t.co/KJnQj5szfn #Pancreatic #CTG @AmCollegeGastro
https://t.co/8yRiQfmcvi #Gastric #Esophageal @DDS_Journal
https://t.co/04fckq8Or8 #Hepatobiliary @CAPR_AACR
https://t.co/wa8YmWUWs3 @VivekSubbiah & @Dr_R_Kurzrock @JCO_ASCO @ASCO
#Universal #germline #genetictesting in all #patients w/ #gastrointestinal/#GI #Cancer
#access #reducedisparities #precisionmedicine #precisiontherapy #clinicaltrials #precisionprevention
https://t.co/oXJ5dLSKTD #WenhuiYang et al.
The #PROCLAIM trial showed, "#Universal #germlinetesting for #patients w/ #ProstateCancer is feasible, safe, and clinically impactful"
current "...#guidelines [@NCCN] may be unintentionally creating barriers to #genetics-informed care in #underrepresented & #underserved populations."
"As frontline providers in #ProstateCancer care, #urologists should lead the charge in translating #genetic insights into personalized, evidence-based management."
c/w
https://t.co/h66HdRztVj #DrNealShore et al. @EurUrolOncol
https://t.co/LKlh85vQqM #DrNealShore et al. @JUrology @AmerUrological
https://t.co/jPwLuOil3Z #DrNealShore et al. @pcan_journal
https://t.co/1FACP4K8cJ #DrNealShore et al. @JCOOP_ASCO
#access #reducedisparities #universal #genetictesting #precisionmedicine #precisiontherapy #clinicaltrials #precisionprevention
https://t.co/v5ynfcq0oY @urotoday
~5% of smokers & >5% of non-smokers w/ #lungcancer have pathogenic variants (PVs) on #germlinetesting inc. #BRCA1 #BRCA2 #CHEK1 #ATM (i.e. #HRR genes)
"...#germline mutations in HRR genes could lead to
more informed #treatment choices in clinical practice...#PARP inhibitors...platinum
chemotherapy..."
c/w
https://t.co/p39eSCwlQq #DrStevenSorscher et al. @JCOPO_ASCO @ASCO
#Universal #germline #genetictesting for all #patients w/ #lungcancer
#access #reducedisparities #precisionmedicine #precisiontherapy #clinicaltrials #precisionprevention
https://t.co/GFpvHmOBzk #DrRamaswamyGovindan et al. @Annals_Oncology
3% of 23K unselected participants w/o #breastcancer (#WISDOM trial) had pathogenic variants (PVs) on #germlinetesting in #BRCA1,#BRCA2,#PALB2,#ATM,#CHEK2,#CDH1,#PTEN,#STK11,#TP53
"30% of women w/ PVs...would be unlikely to be offered #genetictesting under current guidelines."
"...identification of #BRCA1, #BRCA2, & #PALB2 PV carriers w/o a family history of #breastcancer highlights...gap in testing guidelines."
"...higher prevalence of #PALB2 PVs in non-Hispanic Black participants..."
"...several studies...with unrestricted #germlinetesting...have not identified major harms...."
"These findings support the feasibility and acceptability of criteria-independent [#universal] #genetictesting for a diverse group of women [unaffected w/ #breastcancer]...broaden[ing] the group who could benefit from evidence-based cancer surveillance and risk-reduction interventions."
#Universal #germlinetesting for all #patients w/ #breastcancer
#Universal #germlinetesting/#screening for all women for #breastcancer risk?
cit.
https://t.co/hVYDGUHgbt @WhitworthMD et al. @JAMANetworkOpen
#access #reducedisparities #precisionmedicine #precisiontherapy #clinicaltrials #precisionprevention
https://t.co/d5Edr1LdYP #DrKirkpatrickFergus et al. @UCSF @JAMAInternalMed
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