Top Tweets for #HER3DXd
Great perspective by @GrindaThomas on the #SATEEN and #HER3DXd post-ADC trials, both providing prospective data on TOPO1 ADCs after prior T-DXd. Switching ADC target does not seem to be the answer to overcome resistance, if the payload has a similar mechanism of action. @myESMO
#ESMOBreast26: Data from two trials of sequential TOPO1 ADC therapy in metastatic #BreastCancer suggest the emergence of payload cross-resistance, despite differing #MonoclonalAntibody targets, as discussed by @GrindaThomas in the #ESMODailyReporter https://t.co/KTUTISN1Jq

π¨π₯ New NSCLC HER3-DXd π BREAKTHROUGH? in resistant cases from HERTHENA-Lung02!
π 23% progression risk drop & PFS gains!
π https://t.co/nlX7aN2wVc
βΆοΈ Watch on YouTube: https://t.co/v8rRMGKrX6
#NSCLC #HER3DXd #LungCancer #Oncology #ClinicalTrials
@n@nlinmd @DonEford @stolaney1 @DrJNaidoo @itsnot_pink @DFCI_BreastOnc @aftimosp @drsarahsam @JaniceTNBCmets @RenoHemonc @Debeblab @LungCancerEu @kazuki_nozawa @GuiNaderMarta @PathologyPat @SunnieSKim @anmwongNZ @MarvinSPM @MrugalaMaciej @michelle_li @GaiaGriguolo @JavierDavidBen2 @rishabrama @oncobalaji @guicorreiamd @Hilary_Marie_37 @MaheshIddawela @DrChristinaTeng @WDKhatoun
Post #WCLC23 & #ESMO23 + recent @NCCN updates, in 2024 if all becomes available, for #EGFR 19/21, how are you going to sequence Rx in most pts? Any role of #DatoDxD?
#MARIPOSA Ami/Laz
#FLAURA2 Osi/Chemo
#MARIPOSA2 Ami/Chemo
#ATTLAS Chemo/Atezo/Bev
#HerthenaLung01 #Her3DxD
#lcsm @AD@ADesaiMD @esinghimd @EGFRResisters @JackWestMD @CharuAggarwalMD @RenoHemonc @BijoyTelivala @StephenVLiu @RManochakian @BrunaPellini @Joshua_Reuss #OncTwitter
5. 2L for pts with mEGFR after TKI:
a. #CHRYSALIS2: #Amivantamab + #Lazertinib + Chemo, ORR: 50%. High cytopenias. Amivant. Also very active as a single agent in 1st and 2L for #MetExon14
b. #HERTHENALung01: #Her3DXd ADC with activity post TKI. ORR: 30%, mOS ~12 months

@RebeccaDSing discusses 1st abstract from #HER3DXd.
One key takeaway with this ADC platform (both TDXd and HER3DXd) is that you don't have to have high expression to benefit.
#ESMOBreast22

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