Top Tweets for #LineagePlasticity
OncoSKY | Mechanisms Simplified
Can cancer escape therapy by changing its identity?
Lineage plasticity allows tumors to switch phenotype (e.g., EGFR NSCLC → SCLC), bypassing targeted therapy.
A powerful mechanism of resistance.
#oncology #medtwitter #LineagePlasticity
We hope you enjoy our latest in-depth staff interview, "Uncovering the Shape-Shifting Secrets of #ProstateCancer: An Interview with Dr. Nicholas Brady," (@NicholasJBrady and @BradyLabWCM)! #DNA #lineageplasticity #teaching #mentorship #cancerbiology
https://t.co/XOA4zB1VI6
With highly effective #targetedtherapies, #treatment-emergent #histologic #transformation is increasingly recognized.
Addressing this form of #lineageplasticity is not only a requirement but also an opportunity to reshape outcomes for patients with advanced, therapy-resistant disease.
Enjoy our take on this topic!
#CellPlasticity #DrugResistance #CancerResearch #LCSM #LUAD #SCLC #LUSC #NEPC #PDAC
@oncodaily @OncLive @OncoAlert @OSUWexMed
@OhioStateMedOnc @OhioState @OhioStateWIMS
@LUNGevity @lcrf_org @lcfamerica @LiveLung1
@IASLC @AACR
New @CD_AACR review on Hallmarks of Lineage Plasticity by @triparnasen @MAF_Dawson & colleagues
Histologic Transformation in Cancer: The Path for Clinical Translation
https://t.co/PpCqYRksk4
🧵(2/3)
In this review, we:
🔹 Describe the #hallmarks of #lineageplasticity in #lungcancer and #prostatecancer
🔹 Highlight the complexities that make clinical decision-making so difficult 🔹 Examine the utility of #tissue and #liquidbiopsy for detection and tailoring #treatments
🔹 Discuss emerging #therapeutic strategies and novel #molecular targets
🔹 Outline a framework for #clinical translation and #DrugDevelopment
#CellPlasticity #DrugResistance #CancerResearch
#LCSM #biomarker #detection #monitoring #liquidbiopsy
Thrilled to share some exciting news – the #SenLab has secured our #secondR01 ! 🥳
This new funding will support our research of the mechanisms of #drug #resistance in #lungcancer, focusing on understanding the molecular drivers of #lineageplasticity and identifying new #therapeutic targets. 🧬💊
We’re eager to push the boundaries of what’s possible in #lungcancer #research and contribute to new strategies for tackling this challenging disease.
This grant will also enable us to grow our team, so stay tuned for opportunities to join our lab! https://t.co/tf2HiERUPr
Grateful to the @NIH @NCI for this incredible support and to my amazing lab members and collaborators who make this work possible.
Onward and upward! 🚀
@IcahnMountSinai @TischCancer
#NIHfunding #R01 #LungCancerResearch #LineagePlasticity #DrugResistance #TherapeuticInnovation #TeamScience #CancerResearch #SCLC #EGFR #LUAD
Learn about the world of #LineagePlasticity in #ProstateCancer!
Our latest article by @Shaghayegh_NRZ explores how epigenetic changes drive the shift from castration-resistant prostate cancer to neuroendocrine prostate cancer.
Read at https://t.co/TZivjoVpMJ
#ThisIsEpigenetics
Best conference I have attended, amazing talks and fantastic venue. Presented our latest work on prostate cancer lineage plasticity, published in @CD_AACR #EMBOCancerEvo #lineageplasticity
New #CancerHallmarks review in the January 15th issue—
#LineagePlasticity: The New Cancer Hallmark on the Block, by @arnavmehta3 and @BenStanger01.
https://t.co/tLr78Z2QvZ
@MGHMedicine @MGHCancerCenter @harvardmed @PennMedicine
Excited to be at #ESMO23 to present unpublished data from the @charlesrudin lab on a promising therapeutic target suppressing #lineageplasticity & neuroendocrine transformation in #lungcancer & #ProstateCancer. @MSKCancerCenter @MSK_DeptOfMed #LCSM
Starting soon! 📢🔥
@LUNGevity’s International #LungCancer #Survivorship #Conference geared towards people with #lungcancer, #caregivers, & #advocates. #ILCSC23. Looking forward to speaking on #SCLC #lineageplasticity #resistance.
@acmoorephd fantastic lineup!
@IcahnMountSinai
You don't want to miss the star-studded lineup at @LUNGevity's #ILCSC23! Day One @CharlesSwanton @LuisRaezMD @triparnasen @MarcusDGon @chulkimMD @ADesaiMD (1/3)
Interested in #lineageplasticity & neuroendocrine transformation in #lungcancer & #ProstateCancer? Excited to present at #WCLC23 on a therapeutic target potently suppressing transformation on targeted therapy, on Sep 12th at noon. @MSKCancerCenter @MSK_DeptOfMed @charlesrudin lab
Amazing @jmchan88 presenting our work in #lineageplasticity and LUAD to neuroendocrine transformation at #WCLC23. Starting his own lab in @MSKCancerCenter and looking for postdocs and technicians. Coolest guy working on the coolest topic with the coolest techniques. Watch out!
Looking forward to speaking at @LUNGevity’s International #LungCancer #Survivorship #Conference geared towards people with #lungcancer, #caregivers, and #advocates.
Thank you for the invitation @acmoorephd #ILCSC23
@IcahnMountSinai #SCLC #lineageplasticity #resistance @lcsmchat
You don't want to miss the star-studded lineup at @LUNGevity's #ILCSC23! Day One @CharlesSwanton @LuisRaezMD @triparnasen @MarcusDGon @chulkimMD @ADesaiMD (1/3)
#LineagePlasticity and neuroendocrine transformation are driven by convergent molecular changes in #LungCancer & #ProstateCancer. We describe a target with a clinically available inhibitor, able to suppress transformation and delay treatment resistance. https://t.co/6sGtXKRNBN
A new @ScienceTM study led by @AlvaroQuintanal and @charlesrudin suggests that inhibiting the protein exportin 1 could help prevent or treat neuroendocrine transformation in #LungCancer and #ProstateCancer. https://t.co/3TuHbv7Xtk
Only a handful of ASCL1 regulators are known. Filling these gaps @NakisaTabrizian showed a trypsin receptor kinase (ROR2) regulates ASCL1 via ERK/CREB to influence #LineagePlasticity in #ProstateCancer.
@AminaZoubeidi
📢 Thrilled to share the main paper of my PhD🎉 Gratitude abounds for my incredible lab members, especially my supervisor @AminaZoubeidi, @Shaghayegh_NRZ
Click 👇🏻to find out how inhibiting ROR2 abrogates ENZ-induced plasticity via regulating ASCL1
https://t.co/ETfIhwszOx
SOX2, a key TF for transformation, is induced by TP53/RB1 inactivation, but downregulated by selinexor, thus hindering #lineageplasticity. Indeed, if we ectopically overexpress SOX2, we can rescue the transformation neuroendocrine phenotype.
Neuroendocrine transformation of adenocarcinomas occurs frequently upon treatment with targeted therapy, leading to poor prognosis. We have predictors of high risk of transformation (TP53/RB1 inactivation), but not therapies available to prevent this #lineageplasticity phenomenon
Excited to see the latest @charlesrudin lab paper published in @ScienceTM: "Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 down-regulation in lung and prostate cancers". #lungcancer #prostatecancer #SCLC #lineageplasticity https://t.co/sKHYNaave7
Paper formally accepted!!!
Second paper accepted from the Sen-Lab as we complete exactly one year at @IcahnMountSinai @TischCancer
Grateful for my awesome team!
More details to follow ❤️
#lungcancer #SCLC #biomarker #resistance #lineageplasticity #transformation #WomenInSTEM
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