Top Tweets for #LobularBC
@JaniceTNBCmets @abcdiagnosis I learned abt #densebreasts on the same day I learned abt #lobularBC which was the same day I learned mamms aren't perfect cuz they can't read dense breast tissue well, esp w/#lobular, which was also the same day I learned I had both & became @double_whammied. The End. #bcsm
Nobody wanted 2 ignore the signs of #breastcancer more than me, but I hauled my scared self 2 a doc 4 a mamm (which was clear) & an ultrasound (which found 4 tumors). I had #lobularBC stage 3. Took all recom'd treatment & I'm still here 14 yrs later. #FUcancer #dothehardthing
@jayfrombklny @Phil_Lewis_ When people like @ThanksCancer and @double_whammied cultivate open discussions it doesn't just help people with cancer, those discussions help those who will eventually get cancer, have relatives/friends with cancer, be better informed, and counters the ignorance floating around.
๐ข F Y I:
* Mamms aren't perfect
* #Breastdensity matters! (dense tissue can mask #BC)
* #LobularBC & #inflammatoryBC don't necessarily make lumps. Look 4 changes!
* Mamms often miss #lobular #breastcancer (cuz it grows in lines, not lumps) #BCAM #bcsm
https://t.co/gqC6JyY1py
It's #BCAM! Do u know abt #lobular #breastcancer?
* #LobularBC doesn't necessarily make a lump
* This makes it hard 2 find on mammogrms
* Esp hard when u have #densebreasts
* AND hard 2 find when it spreads (stage 4)
* AND it can spread 2 weird spots! ๐
https://t.co/sYxbP3un7o
Wonderful to see more #lobularBC research come through! Thx for posting, Rebecca!
#lobmob #globmob @LobularBCUK @LobularBCA @lobbccanada @LobularIreland @ELBCAdvocates
We're right on the cusp of #BreastCancerAwareness month, so in the spirit of striving to make this #BreastCancerAction month, we've dropped a new preprint. A ๐งต on our latest work in invasive #lobular carcinoma, ILC /1 https://t.co/vRL9nwcNo1
Yes, please! ๐
#lobularBC is still understudied. And #ILC patients are still being dismissd & ignored & Dx'd late. AND excluded frm #clinicaltrials. Let's fix this!
@LobularBCA @LobularBCUK @lobbccanada @LobularIreland @abcdiagnosis @ThanksCancer @OncoAlert #lobmob #globmob
Letโs move this conversation forward for Lobular and guidelines! @LobularBCUK @BCCare @CRUKresearch @NICEComms

Great news, Matt!
Sending out the bat signal for members of the #lobmob #globmob #lobularBC #ILC! Get to know this oddball #breastcancer! #knowledgeispower @ELBCAdvocates @lobularBCA
We lost one of our beloved #lobmob members this week. Rest in power and peace, @GwenManchion (at center below, in orange). Thanks for your dedication & hard work & for spending so much of your precious time advocating for others.
#stage4needsmore #lobularBC @fredhutch #shero
Greetings from the #lobmob! Great 2 connect w/my #lobular #breastcancer peeps at #SABCS22. Happy 2C more & more research focused on our understudied #BC. TY @oesterreichs @LPseattle @Otto_DFCI @Adrianvlee Drs. Rachel Jankowitz & Rita Mukhtar, etc. 4 putting the spotlight on #ILC!

Check out all the #lobular #breastcancer research at #asco2024!
THX @JAMouabbi & all the wonderful researchers, oncologists, surgeons, radiologists, patient advocates & others who helped put #lobularBC on the research map. Biggest props 2 @LPSeattle 4 launching @lobularbca๐ช
5 #ILC Abstracts will be presented at #ASCO24 as Poster Presentations on Sunday June 2nd at 9:00 AM - 12:00 PM
1๏ธโฃ Racial disparities in presentation and survival for lobular breast cancer
Presenter: @SimranSandhu17_ (University of Galway, Ireland); @DavidLimMD
Data: SEER database study with 38,769 ILC patients
Findings: Black women present with more advanced disease; Asian women are younger at diagnosis. 5-year overall survival for Black women is worse.
Takeaway: We must bridge the gaps in care for ILC patients across different races.
2๏ธโฃ The multiomic tumor microenvironment landscape of ILC
Presenter: @JAMouabbi (MD Anderson Cancer Center) @BostonGeneCorp @Hensley1552
Data: MxIF on 2,139,084 cells from FFPE whole-slide tissues
Findings: Detailed multiomic analysis reveals 40% of ILC samples are immune enriched (potential for immunotherapy) and 30% are highly vascularized (potential for anti-angiogenesis therapy).
Takeaway: Many ILC patients may benefit from immunotherapy or anti-angiogenesis regimens.
3๏ธโฃ Neoadjuvant targeted therapy in HER2-mutant lobular breast cancer
Presenter: Laura Kennedy (Vanderbilt-Ingram Cancer Center); @AriellaHanker @CarlosArteagaMD
Background: 10% of ILCs have HER2 (ERBB2) mutations, linked to ET resistance and worse prognosis.
Study: NCT05919108, Phase II trial for 30 patients with Stage I-III ILC and HER2 mutation, receiving letrozole + neratinib for 6 months pre-surgery.
4๏ธโฃ Transcriptomic analysis of cAMP/PKA/CREB signaling in ILC
Presenter: @Susruthapn (Washington University School of Medicine); @oesterreichs
Data: RNA-seq from three large breast cancer databases
Findings: Up-regulation of cAMP/PKA/CREB signaling in ILC compared to NST/IDC.
Takeaway: Unique signaling pathway in ILC could lead to novel therapeutic targets.
5๏ธโฃ Clinical-pathological characteristics and multigene assay risk scores in ILC
Presenter: Young-Won Lee (University of Ulsan College of Medicine, Seoul, Korea); @AsanMedicalCtr
Data: Retrospective analysis of 238 ILC cases
Findings: Predictive factors for ODX recurrence score in ILC differ from IDC.
Takeaway: Need for ILC-specific risk prediction tools.
#bcsm #EndCancer #ILC @LobularBCA @LobularBCUK @LobularIreland @lobbccanada @elbcc @double_whammied @lbhutcheson @OncoAlert @ASCO @VJOncology @OncBrothers @OncData @Keira_OncData
Nice to see @GMA give some attention to #breastcancer subtypes! #LobularBC #InflammatoryBC #NoLumpStillCancer
Much more info at @lobularBCA & @talkIBC
Huge props to patients 4 sharing their story & getting the word out about #what2look4 #knowyourbody #knowyourbreastcancer
โI never felt a lump โฆ so it really caught me off guard.โ
Not all breast cancers present with a mass. Two survivors of these subtypes of breast cancer tell @eriellereshef their stories.
Let's talk liquid biopsies! These could be quite helpful in a #cancer that's super hard to image! #ilcsymposium #lobularBC #lobmob #globmob


Another great talk on imaging of #lobularBC by Dr. Gary Ulaner. #ilcsymposium FES-PET may be the future #SOC for imaging of #lobularBC. #lobmob #globmob

FES-PET is better in some areas than others. Lung, bone, brain - great! Liver, not so good.#ilcsymposium #lobularBC

Up now @fredhutch's Dr. Hannah Linden speaking on the new FES-PET estrogen-based imaging tracer to better see #lobularBC. Sensitivity is good, but not perfect. #ilcsymposium #lobmob

Mammography and CT scan may not be enough for #lobularBC screening. Also ... it doesn't make biologic sense to surveil it like #ductal. Lots of promise w/ liquid biopsy. But we need to consider more MRIs for surveillance. #ilcsymposium #lobmob #globmob

Great talk from @ClaireTTweets on feeling unseen and unheard as a #lobularBC and #LGBT patient. #ilcsymposium #DEIJ #lobmob @LobularBCUK We need to @End_Disparities !

Some really good points in this thread! #ILCSymposium #lobularBC
Esp agree abt RECIST measurable disease criteria for #clinicaltrials. Round hole trial criteria doesn't work 4 square pegs! Let's make this better. AND yes, @CMSGov @POTUS need to fix the #Medicaid out-of-state CF!
Beautiful tribute to @LPseattle and the announcement of a brand new #lobularBC lectureship series in her name. Thank you Flora Migyanka! #ilcsymposium #lobmob #globmob

All the ways we are getting the word out about #lobularBC. Thank you Julia Katherine! #ilcsymposium @LobularBCA #lobmob

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