Top Tweets for #METHYLATION
25 years ago today, I opened my lab as a Principal Investigator. 🎂Since then, the #Cancer #Epigenetics Group at @CNIOStopCancer @idibell_cat @CarrerasIJC @IRSantPau has explored DNA #methylation, #histone and #RNA modifications and non-coding RNAs in #Oncology, #Rettsyndrome and other diseases. But what I'm proudest of is the many members who built this #science with me and now they are successful on their own. Thank you. 🙏
Here you can see a cryoEM structure of DNMT3A2/3B3 in complex with H3K36me2 di-nucleosome (PDB code: 9Y4P)
Rendering by Francisco J. Enguita (@fenguita) made with #ProteinImager
#SciArt #molecularart #dna #genome #epigenetics #methylation #methyltransferase #nucleosome
!! An epigenetic link !!
Early-life #internalizing behavioral problem trajectories precede childhood #asthma, which may be mediated by #methylation, especially of #HAL and #MAD1L1.
Learn more 🔗 https://t.co/dt1XUJaoCz
.
#pai_journal #anxiety #birthcohort #DNAmethylation #internalizingbehavior #mentalhealth #preschoolchild #epigenetic
We used single-cell multiomics to trace the MDS-to-AML trajectory upon #HMA treatment and uncovered how #DNA #methylation clones evolve along the way. Featured in @LeukemiaJnl !
#SingleCellGenomics #AML #MDS #CancerBiology
https://t.co/DjldbtHZ3V
Article✍️A novel small molecule #inhibitor targeting #KHSRP #methylation suppresses #colon #cancer progression. From Dr. Ma @ZhejiangUniversity; @ZJU_China; @Sciencedirect; @ElsevierConnect.
https://t.co/8uDUzs7rGc.
🧬 #BehindtheStudy:
Dr. Josh Mitteldorf summarizes his #research perspective #published in Volume 17, Issue 5, titled “Methylation clocks for evaluation of anti-aging interventions.”
🎥 https://t.co/QSCGFznuaJ
#author #interview #aging #methylation #agingclocks #publishing #oa
Talent alert! Great time with former PhD student Carlos A. Garcia-Prieto @carlosgarciapri . He excelled in the computational study of DNA #methylation in COVID-19, CAR-T cells and mouse models and now investigates #iimmune and #melanoma #multiomics in @diegochowell lab at @IcahnMountSinai @MountSinaiNYC
#DNBSEQ platforms now support the #TAPS+ workflow, developed by @WatchmakerGeno1 , enabling simultaneous #methylation profiling and variant calling from a single library, with as little as 1 ng input.😀
https://t.co/dEZzYXM9DN #genomics #DualOmics
Quantifying DNA #methylation changes at top differentially methylated CpGs (DMCs) can help predict clinical presentation in patients with systemic #lupus erythematosus (SLE). A recent study demonstrated this by evaluating the associations between an SLE methylation risk score (MRS, based on 17 top differentially methylated CpG sites), HLA-DRB1*03:01, a non-HLA polygenic risk score (PRS derived from 57 variants), and various clinical and immunological phenotypes across two independent cohorts of SLE patients and controls.
◦ MRS strongly links to an IFN-high phenotype: Higher MRS correlated robustly with elevated serum IFN-α2 levels (P = 1.04 × 10⁻¹⁴). It was also significantly associated with discoid lupus erythematosus (DLE), discoid rash, hematologic disorders, hypocomplementemia, general immunologic involvement, anti-SSA/SSB/RNP/Sm autoantibodies (P < 0.05 across both cohorts), higher disease activity in the discovery cohort (P = 1.50 × 10⁻⁴), multiple autoantibody positivity (P < 1.0 × 10⁻¹⁵), and HLA-DRB1*03:01 carrier status (P < 1.0 × 10⁻³).
◦ PRS captures distinct clinical features: Higher PRS was associated with nephritis, anti-dsDNA positivity, and a lower prevalence of anti-SSB antibodies (P < 0.05). Notably, the PRS showed no association with the MRS (P = 0.35) or IFN-related features.
Overall interpretation: The MRS and PRS capture distinct SLE subsets and underlying pathogenic pathways. The MRS defines an IFN-high, HLA-DRB1*03:01-linked phenotype characterized by multiple autoantibodies (specifically anti-SSA/SSB), whereas the PRS primarily drives nephritis risk. These findings highlight the value of integrating genetic and epigenetic markers to resolve SLE heterogeneity and disease mechanisms.
*Vestin H, Oparina N, Eloranta ML, et al. Methylation and polygenic risk scores capture different features of Systemic Lupus Erythematosus. Rheumatology (Oxford). 2026;65(8):keag359.
🔗https://t.co/pddFfuDJiK
Big fan of @JoeEcker research at @salkinstitute. Tour de force in @ScienceMagazine to map at #singlecell resolution DNA #methylation and #3D structure of many human tissues. Fascinating data and an extremely useful #epigenetic landcape reference for follow-up work!
And you need single cell (not bulk) methylation atlases of all body cell types in order to “see” the epigenetic cell origins of microglia and other lineages -it’s written on top of the genome https://t.co/XX1fLUBK1H
🧬 #BehindtheStudy:
Dr. Josh Mitteldorf summarizes his #research perspective #published in Volume 17, Issue 5, titled “Methylation clocks for evaluation of anti-aging interventions.”
🎥 https://t.co/QSCGFznuaJ
#author #interview #aging #methylation #agingclocks #publishing #oa
Our recent Review of #DNA #methylation in #braintumors highlighted @JNNP_BMJ
Building on our experience to offer the tests @MayoClinicNeuro @MayoClinic @MayoCancerCare @Kenneth_Aldape
Integrating #AI #diagnosis
Our new @JNNP_BMJ review explores DNA methylation profiling in CNS tumor diagnosis and risk stratification. Grateful to our wonderful team of co-authors and mentors, and to the journal for featuring it as an Editor’s Choice.
https://t.co/ZODcPW9AWz
🎉 Welcome to Read #ResearchArticle from #MDPICrystals
📑 On the #DeactivationAnalysis of IM-5 #Zeolite in #Pseudocumene #Methylation with #Methanol
📚 Shumin Hao and colleagues
📌 https://t.co/hy7Q7o7PpH
#CarbonDeposites #IM5 #Deactivation #Alkylation
Your body's ability to process nutrients hinges on methylation. Genetic markers like MTHFR can disrupt this process, meaning you might only utilize 50% of the food you eat. Optimize your health by understanding your genetic blueprint. #Methylation #MTHFR #Health
Not sure which #methylation model to choose for your @nanopore data? 👀
Our lab’s latest paper on benchmarking methylation models might just nudge you in the right direction 🤓 Congratulations to the team! 👏🏼 Check out the thread below! #oxfordnanopore #longreads #genomics
Excited to share our latest publication in Nature Communications🎉
Our work comprehensively benchmarks Oxford Nanopore DNA methylation detection tools across 5mC (CpG & non-CpG), 6mA, and 4mC using bacterial, plant, and mammalian datasets.
Read the paper: https://t.co/8oAd2JsxGn
Happy to see in the current issue of @BloodAdvances @BloodPortfolio @ASH_hematology the DNA #methylation-based classification of #hematolymphoid neoplasms led by David Capper @ChariteBerlin and @Kenneth_Aldape @NIH @theNCI where we have contributed. The study includes >1,600 patient samples! Enjoy.
https://t.co/WIJGjerfU8
Glad to present the final Trends in Cancer @trendscancer published version of our @VeroDavalosVega @FerrerGe article explaing how #DNA #methylation predicts #cancer response to targeted therapies, #chemotherapy and #immunotherapy
https://t.co/xuhhKJ3fUU
Inviting you to read the value of merging #genomics, #methylation #digitalpathology #AI #BrainCancer @MayoPlatform
Zadehlab
@lsyefet @ap_landry @FarshadNassiri @Kenneth_Aldape @justinzw
#transform #CancerCare #meningioma
AI, methylation profiling, and deep learning can help personalize brain tumor treatment and improve meningioma care. Dr. John Halamka and Paul Cerrato explain how in their latest column: https://t.co/1GvVCy5cda
#HealthcareAI #BrainTumors #MayoClinicPlatform
Delighted that our @LeukemiaJnl article about single-cell DNA #methylation (scDNA-Met) clonal evolution in #MDS transformation to #AML is in the 91st percentile of the 177,249 tracked articles of a similar age in all journals according to Altmetric score ! Congrats to the team!
https://t.co/jE4GyGQE9S
Targeted long-read sequencing with adaptive sampling enables the integrated genomic and epigenomic profiling of imprinting disorders. #nanopore #AS #methylation #SV https://t.co/YnqfqvHTV4
Last Seen Hashtags on Sotwe
crushfetish
Seen from Germany
minichat((((((((**********************************************)))))))) +filter:videos
Seen from United States
pytt
Seen from United States
รีทวิตนัดเย็ด
Seen from Thailand
horse mating
Seen from Turkey
snapchat
Seen from Turkey
asian
Seen from Algeria
Ｍ女
Seen from Japan
sislitrAvesti
Seen from Turkey
Trends for you
Most Popular Users
Elon Musk 
@elonmusk
241.5M followers
Barack Obama
@barackobama
118.9M followers
Cristiano Ronaldo
@cristiano
114.6M followers
Donald J. Trump
@realdonaldtrump
111.8M followers
Narendra Modi
@narendramodi
107.1M followers
Rihanna
@rihanna
98.7M followers
NASA
@nasa
92.3M followers
Justin Bieber
@justinbieber
91.8M followers
KATY PERRY
@katyperry
90.1M followers
Taylor Swift
@taylorswift13
84M followers
Lady Gaga
@ladygaga
75.5M followers
Virat Kohli
@imvkohli
73.5M followers
Kim Kardashian
@kimkardashian
70.9M followers
YouTube
@youtube
68.8M followers
Neymar Jr
@neymarjr
66.5M followers
Bill Gates
@billgates
65.3M followers
Selena Gomez
@selenagomez
63.1M followers
The Ellen Show
@theellenshow
62.2M followers
CNN
@cnn
61.8M followers
X
@x
60.7M followers