Top Tweets for #PROOF302
Thank you @mdesantis234 for a beautiful discussion of several complex #bladdercancer datasets. Many thanks to @shilpaonc @ClevelandClinic & @PGrivasMDPhD @fredhutch for driving the genomic analysis in #PROOF302 - impt to prospectively characterize freq of FGFR3m in this setting!
#ASCO2023 Check out our work on FGFR alterations in UC in #PrOOF302 trial of adjuvant infigratinib
@montypal @PGrivasMDPhD @siadaneshmand @sonpavde @kalasri3 @CleClinicMD
poster discussion by #Dr.Maria De Santis today at 3 PM chaired by @apolo_andrea @TomFlaigMD
@RManochakian @cityofhope @MayoClinic @MayoCancerCare You are too kind! What a great opportunity to highlight #bladdercancer trials like #PROOF302 w @siadaneshmand @PGrivasMDPhD et al & #MAINCAV by @shilpaonc thru @ALLIANCE_org. A terrific meeting, @RManochakian! Would not be the same online - glad to be here in person to meet you!
Adjuvant infigratinib as targeted therapy for pts with muscle-invasive #UrothelialCarcinoma harboring susceptible FGFR3 genetic alterations: a randomized, double-blind, pbo-controlled, phase 3 trial #PROOF302. #GU22 @SuzanneColeMD @utswcancer > https://t.co/tD6SEuppvm @WallisCJD
No small feat to summarize this massive experience in #cystectomy from my colleagues at @USC_Urology. Terrific work from @siadaneshmand's group (@APMitra @SumeetBhanvadia @Hoomandjaladat et al) that underscores need to do more post-cystectomy to prevent relapse (eg #PROOF302, IO)
Further moving from ongoing adjuvant trials #IMvigor011, #PROOF302 to multiple first line metastatic #bladdercancer trials.
Thank you @siadaneshmand for highlighting #PROOF302 at #SUO21, a study that addresses an unmet need in #bladdercancer. Need to better understand the role of adj FGFR3i, particularly in niches like #UTUC. Appreciate the @UroOnc CTC! @PGrivasMDPhD @shilpaonc @kalasri3 @OncoBellmunt
Thank you @siadaneshmand for highlighting #PROOF302 at #SUO21, a study that addresses an unmet need in #bladdercancer. Need to better understand the role of adj FGFR3i, particularly in niches like #UTUC. Appreciate the @UroOnc CTC! @PGrivasMDPhD @shilpaonc @kalasri3 @OncoBellmunt
A fantastic @UrolOncol review commissioned by @FaltasLab on FGFR3i in #bladdercancer by @ZeynepZengin @arafflemd @NickSalgia @RamyaRMuddasani & @LuisMezaco, highlighting need for ongoing investigation w FGFR3i (e.g. #PROOF302). Timely pub during #SUO21! @UroOnc @AmerUrological
Proud of @YungLyou who partnered w @PGrivasMDPhD to do an analysis of activity of infigratinib across line of therapy in pts w #bladdercancer. Impt data that points to preserved activity in multiple settings - interesting implications for #PROOF302! https://t.co/LwRup3qvKJ
Honor to discuss points @FaltasLab @shilpaonc #ASCO21 @ASCO AMBASSADOR @apolo_andrea PROOF302 @montypal @siadaneshmand JavelinBladder100 @tompowles1 S1806 @Parminder1699 KN992 @ArjunBalarMD EA8185 @MonikaJoshimd & other studies! @BladderCancerUS @arkhaki @neerajaiims @OncoAlert
Bravo. An excellent discussion (after a rocky start π) by @OncoBellmunt on the adjuvant landscape. Agree w both he & @tompowles1 - we need to tease out those pts who truly benefit. Genomic selection (as in #PROOF302) & ctDNA (IMvigor011) one way fwd.
Confusion at the start of the latest Uromigos paper of the month https://t.co/mgC5ybCjIT
@MichalisLiontos @tompowles1 @PGrivasMDPhD @OncoBellmunt @Uromigos I would - same for #PROOF302 w infigratinib, honestly.
Congrats @tompowles1 on a vital study. We need to support studies that employ a biomarker-based design such as this #PROOF302, exploring adjuvant FGFR3i w #infigratinib. @siadaneshmand @OncoBellmunt @shilpaonc @PGrivasMDPhD @AndreaNecchi @BladderCancerUS
Many muscle invasive bladder cancer patients are cured with surgery. These patents donβt need adjuvant therapy. CtDNA identifies patients at risk of relapse. ctDNA+ves also appear to benefit from adjuvant atezo. Imvigor011 (below) validates this and has screened its first patient
Great discussion w @IyerGopa #ArleneSiefkerRadtkeMD #SethLernerMD re: #biomarkers & #bladdercancer. Broad support for #PROOF302 - even in face of exciting data from #CM274, so critical to keep this & the "tie-breaker" @ALLIANCE_org #AMBASSADOR in mind!
This is where #PROOF302 comes in. With infigratinib (a potent & specific FGFR3i), we plan to enroll FGFR3m pts (seen at higher rate in #UTUC) who (based on work from @FaltasLab) may have an immune-depleted phenotype. This #SUO-led study is enrolling now internationally. (7/9)
Glad to see common themes with our recent review on UTUC biology in twin journal @EUplatinum with @DrShariat @JimCatto and others https://t.co/zrAKKy4uVy
Support for #PROOF302 with adjuvant #infigratinib is important to test these concepts prospectively.
@montypal agree with you! Great work @DrJohnSfakianos et al. We keep working on #PROOF302 @siadaneshmand @shilpaonc @YungLyou @TiansterZhang @OncoBellmunt @sonpavde @WorldBladderCan @IBCG_BladderCA @SeattleCCA @fredhutch @uwurology @spsutkaMD @JLWrightMD @gorejohn @schadegr
Thx @DrJohnSfakianos for leading this review of key genetic differences between UTUC & LTUC in @EurUrolOncol w @SurenaMatinMD @siadaneshmand @ERPlimackMD @MRoupret. At the expense of sounding like a broken record, article underscores rationale for #PROOF302 w adj #infigratinib.
Thx @DrJohnSfakianos for leading this review of key genetic differences between UTUC & LTUC in @EurUrolOncol w @SurenaMatinMD @siadaneshmand @ERPlimackMD @MRoupret. At the expense of sounding like a broken record, article underscores rationale for #PROOF302 w adj #infigratinib.
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