Top Tweets for #Prc2
Epigenetics Update - Polycomb Repressive Complex 2 drives flow-sensitive endothelial states underlying vascular inflammation and disease https://t.co/TBGdaMtdtG
Divyesh Joshi & Martin A. Schwartz (@YaleMed) in @PNASNews
#Epigenetics #PRC2
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https://t.co/WmSYDGWPJD
Epigenetics Update - Decoding stage-specific functions of PRC2 in early embryogenesis uncovers roles in preimplantation development and primordial germ cell fate https://t.co/Pq9cWmxreZ
#Epigenetics #PRC2 #PGCs #EmbryoDevelopment
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https://t.co/WmSYDGWPJD
Epigenetics Update - Self-clustering of three CBX2 molecules drives PRC2 to promote facultative heterochromatinization of Polycomb target genes https://t.co/PKv55HAido
#Epigenetics #PRC2 #Chromatin
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Hi-res insights without cell sorting; https://t.co/WmSYDGWPJD
Epigenetics Update - Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains https://t.co/doyD9dy7Vt
Edwina McGlinn & Chen Davidovich in Mol Cell
#Epigenetics #PRC2 #H3K27me3
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Perfect for cancer, immunology, and aging; https://t.co/WmSYDGWPJD
Epigenetics Update - The conserved N-terminal SANT1-binding domain (SBD) of EZH2 regulates PRC2 activity https://t.co/odArBIeNtB
Agata L. Patriotis (Rockefeller Uni) in Genes Dev
#Epigenetics #EZH2 #PRC2
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Perfect for cancer, immunology, and aging; https://t.co/WmSYDGWPJD
Epigenetics Update - EZHIP restricts noncanonical PRC2 binding and regulates H3K27me3 intergenerational inheritance and reprogramming https://t.co/YX6gNIRToS
#Epigenetic #Chromatin #H3K27me3 #PRC2
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High-res insight without cell sorting; https://t.co/WmSYDGXnzb
Epigenetics Update - Distinct specificity and functions of PRC2 subcomplexes in human stem cells and cardiac differentiation https://t.co/ELRBuK4v7i
Yicheng Long (Weill Cornell) in Mol Cell
#Epigenetics #PRC2 #H3K27me3
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Gain high-resolution insight; https://t.co/WmSYDGWPJD
In this recently published article, Sushant Bhattacharya et al. @IGIBSocial explore the crosstalk between #Dicer inhibition, the #PRC2 complex and histone methylation and the consequent implications of this event on wound closure.
Read it here ๐ https://t.co/YX4yWrfQG3
New research from the Davidovich Group @MonashBDI suggests #PRC2 inhibitors may not be effective in cancers with non-dividing cells, highlighting the need to consider how drugs interact with dividing vs. non-dividing cells when developing #cancer treatments.
๐งต 1/ Weโre excited to share that our new paper with @adrianbracken lab is out ๐ In this study (which began 10 years ago!) we explore the biology of PRC2 and PRC1 in non-dividing cells. We also explore the effects of PRC2 inhibitor drugs on these cells. Hereโs what we found๐
8/ Thanks to all amazing authors and collaborators who made this possible; @RachelMcCole, @JMNolan89, @conwayer1 , Gerry Brien, @HNeikes and the labs of Lindsey James, @DavidovichLab , @LabVermeulen & @pasini_lab
#CancerResearch #Chromatin #EZH2 #PRC1 #PRC2 #EZH2Inhibitors
New Dec issue @TrendsImmuno! Sex responses in #COVID19, #NKcell KIR-HLA-I & disease, #neuroimmune interactions in #Alzheimers, neuroimmune barrier at #olfactory epithelium, #cytosolic delivery of #innateimmmune #agonists, #PRC2 in innate immunity, & more!! https://t.co/2XK0XKMQjU
๐ซNEW by @a_z_usa__ & co: JARID2-#PRC2 initiates H3K27me2 deposition in the 8-cell-to-morula transition, following H2AK119 mono-ubiquitylation deposition. It is also required for subsequent #H3K27me3 deposition at the #blastocyst.
๐๐ฟhttps://t.co/wSUgdaUHFK
https://t.co/ZjmH5w77aj
Great work in @NatureComms led by amazing Roshana Thambyrajah @roshana_t and @BigSpinLab from @HMar_research @CarrerasIJC showing how #hematopoietic #stemcells #HSCs proliferation depends on an NF-ฮบB inhibitor activity and #polycomb #PRC2; privileged to contribute.
https://t.co/sNqowLJfOF
Dr @QiZhang85 Group Leader @SAiGENCI, @UniofAdelaide demonstrated how #RNA regulates #PRC2 mechanistically, through a combination of approaches including #biochemistry, structural #biology, #cellbiology & #genomics at #JCSMR Director's Seminar last week hosted by Prof @EduEyras
4/6: Similarly for human PRC2, which is notoriously challenging to solve its cryo-EM structures - required crosslinking & surface adsorption, by adding LEA proteins before freezing, we determined cryo-EM maps of PRC2 at comparable resolutions to those previously reported. #PRC2
SVALKA-POLYCOMB REPRESSIVE COMPLEX2 #PRC2 module controls C-REPEAT BINDING FACTOR3 induction during #cold acclimation #Arabidopsis #plant https://t.co/CYe5zw53Ot @PlantPhys
The #Polycomb repressive complex 2 represses TEs in a broad range of eukaryotes. #PRC2 #Epigenetics
The Polycomb repressive complex 2 deposits H3K27me3 and represses transposable elements in a broad range of eukaryotes
https://t.co/plqJxKh7yj
New study in Current Biology by Frederic Berger's group reveals new origin story for #PRC2! Initially a defender against #transposons in #Eukaryotes, PRC2 evolved to silence protein-coding genes. https://t.co/DqhoWG1wRM
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