Top Tweets for #Progerin
📢 #SEQT_articles
"First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria "
@MedChemLab_ucm, @quimicasUCM
#PROTACs #Progeria #Senescence #Progerin
Subati & colleagues found that #progerin expression in adult cardiomyocytes is sufficient to confer a #hypertrophy phenotype. Learn more at https://t.co/Le4qjuHLIR
@jonathanBrownMD
#HGPS #HutchinsonGilfordProgeriaSyndrome #Aortopathy
The age-related accumulation of immature Lamin A (either #Progerin or Farnesyl-Prelamin A), but not loss of Lamin B1, drives the mechanical stress-induced loss of aortic #SmoothMuscleCell
A careful comparative analysis among
1⃣LmnaG609G/+
2⃣Zmpste24-/-
3⃣SM22a-Cre::Zmpste f/f::LmnaPLAO/PLAO🐭
A very important paper on Vascular Laminopathy🤓
#CellDeathDis @cddpress 2025
https://t.co/N3L1jChHRP
Lack of adverse vascular phenotypes in mice with postnatal induction of #EndothelialCell #Progerin
Lmna LCS/LCS::Cdh5-CreERT2
Tamoxifen at 1.5-mo
Monitored till 22-mo
Normal lifespan, No #Progeria
No Cardiac Fibrosis/Dysfunction
No macrovascular Fibrosis/Inflammation
No arterial #SmoothMuscleCell Loss
No aggravated Atherosclerosis
Vicente Andrés lab @Aging_Cell 2024
https://t.co/D41DTJIhVd
Speeding up Alzheimer's research: Progerin turbocharges cellular models for quicker drug screening 🧠💡🔬 https://t.co/bvDZk5QIga #Alzheimers #Progerin #CellularModel #DrugScreening #Dementia #Tau #Amyloid #Aging #Neuroscience #Pathogenesis @SciReports
In vivo half-lives of Lamin A & #Progerin in progeroid tissues (🫀/Aorta/Fat) are weeks & months🤯
Lmna C609G🐭-> slow global protein turnover (ribosome, mitochondria, cytoskeleton)
Interesting! Important for gene editing therapy
@abbybuch bioRxiv 2023
https://t.co/Q3F12KMZKF
📢New Recommended Reading
#Progerin induces a phenotypic switch in vascular smooth muscle cells and triggers #replicationstress and an #aging-associated secretory signature by @CollBonfillN et al.
https://t.co/ptjekFs10t
#cardiovasculardisease
#telomerefragility
My last paper from my postdoc is finally out! 🍾🥂🥳
Thanks to all for your contributions and to @AHA_Research @AHA for my fellowship
#Progeria #raredisease #vasculardisease
@gonzalo_lab @Progeria @GeroScienceAGE
https://t.co/729QauqqWC
Optimized #antisense #oligonucleotides that can reduce #progerin tissue expression in vivo pave the way for development of a novel therapeutic approach for Hutchinson-Gilford progerin syndrome. #ASO #GeneTherapy @NCITomMisteli @NIH
https://t.co/2NSewN7CCz
Optimized #antisense #oligonucleotides that can reduce #progerin tissue expression in vivo pave the way for development of a novel therapeutic approach for Hutchinson-Gilford progerin syndrome. #ASO #GeneTherapy @NCITomMisteli @NIH
https://t.co/2NSewN7CCz
A modified antisense oligonucleotide that blocks pathogenic splicing of progeria transcripts reduces the production of #progerin in key target organs and extends animal lifespan in a mouse model of #progeria syndrome. #ASO #Genetherapy @NIHDirector
https://t.co/EJwlPEVVFb
JCI - #prematureaging #myocardialinfarction #Endothelial #progerin expression causes #cardiovascular #pathology through an impaired #mechanosignaling https://t.co/ua2ZnHrBDx
#Progeria : Research of a rare #genetic disease
#progerin #clinicalresearch #Medical #casereports #ChildCare4All #Healthcare #PalliativeCare #hospice #eHealth #DigitalHealth #onmedic #Retwet #twitter
https://t.co/6cyUCIIgWM via @ElsaReeth
@Primary_Immune @Progeria Thanks for making me aware of this interesting paper.
Original research here: A Cell-Intrinsic #Interferon-like Response Links Replication Stress to Cellular #Aging Caused by #Progerin.
#HGPS #Progeria #Calcitriol #ReplicationStress #STAT1 #IFN #LamininA
https://t.co/Fgpd5lDIm5
Stress and #aging and NRF2. Paper from Misteli - https://t.co/tjTzx6fdt3; a Preview too - https://t.co/DL8lpuzenv
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