#progerin - Twitter Hashtag

6 months ago

📢 #SEQT_articles "First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria " @MedChemLab_ucm, @quimicasUCM #PROTACs #Progeria #Senescence #Progerin

SocEspQuimTerap's tweet photo. 📢 #SEQT_articles

"First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria "

@MedChemLab_ucm, @quimicasUCM
#PROTACs #Progeria #Senescence #Progerin https://t.co/uyzSZg6b3q

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Circulation Research @CircRes

11 months ago

Subati & colleagues found that #progerin expression in adult cardiomyocytes is sufficient to confer a #hypertrophy phenotype. Learn more at https://t.co/Le4qjuHLIR @jonathanBrownMD

CircRes's tweet photo. Subati & colleagues found that #progerin expression in adult cardiomyocytes is sufficient to confer a #hypertrophy phenotype. Learn more at https://t.co/Le4qjuHLIR

@jonathanBrownMD https://t.co/LBxaTOl25T

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Eugene

@ScienceDJX

12 months ago

🧑‍🔬Researchers have discovered that the toxic protein #progerin, which drives premature aging, is cleared from cells through a lysosome-dependent pathway, and activating #lysosome biogenesis can reverse cellular senescence by enhancing this process.

ScienceDJX's tweet photo. 🧑‍🔬Researchers have discovered that the toxic protein #progerin, which drives premature aging, is cleared from cells through a lysosome-dependent pathway, and activating #lysosome biogenesis can reverse cellular senescence by enhancing this process. https://t.co/u5iUhQYDun

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Hao Yin

@HaoYin20

about 1 year ago

#HGPS #HutchinsonGilfordProgeriaSyndrome #Aortopathy The age-related accumulation of immature Lamin A (either #Progerin or Farnesyl-Prelamin A), but not loss of Lamin B1, drives the mechanical stress-induced loss of aortic #SmoothMuscleCell A careful comparative analysis among 1⃣LmnaG609G/+ 2⃣Zmpste24-/- 3⃣SM22a-Cre::Zmpste f/f::LmnaPLAO/PLAO🐭 A very important paper on Vascular Laminopathy🤓 #CellDeathDis @cddpress 2025 https://t.co/N3L1jChHRP

HaoYin20's tweet photo. #HGPS #HutchinsonGilfordProgeriaSyndrome #Aortopathy

The age-related accumulation of immature Lamin A (either #Progerin or Farnesyl-Prelamin A), but not loss of Lamin B1, drives the mechanical stress-induced loss of aortic #SmoothMuscleCell

A careful comparative analysis among
1⃣LmnaG609G/+
2⃣Zmpste24-/-
3⃣SM22a-Cre::Zmpste f/f::LmnaPLAO/PLAO🐭

A very important paper on Vascular Laminopathy🤓

#CellDeathDis @cddpress 2025
https://t.co/N3L1jChHRP

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Hao Yin

@HaoYin20

almost 2 years ago

Lack of adverse vascular phenotypes in mice with postnatal induction of #EndothelialCell #Progerin Lmna LCS/LCS::Cdh5-CreERT2 Tamoxifen at 1.5-mo Monitored till 22-mo Normal lifespan, No #Progeria No Cardiac Fibrosis/Dysfunction No macrovascular Fibrosis/Inflammation No arterial #SmoothMuscleCell Loss No aggravated Atherosclerosis Vicente Andrés lab @Aging_Cell 2024 https://t.co/D41DTJIhVd

HaoYin20's tweet photo. Lack of adverse vascular phenotypes in mice with postnatal induction of #EndothelialCell #Progerin

Lmna LCS/LCS::Cdh5-CreERT2
Tamoxifen at 1.5-mo
Monitored till 22-mo

Normal lifespan, No #Progeria
No Cardiac Fibrosis/Dysfunction
No macrovascular Fibrosis/Inflammation
No arterial #SmoothMuscleCell Loss
No aggravated Atherosclerosis

Vicente Andrés lab @Aging_Cell 2024
https://t.co/D41DTJIhVd

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News Medical @NewsMedical

almost 3 years ago

Speeding up Alzheimer's research: Progerin turbocharges cellular models for quicker drug screening 🧠💡🔬 https://t.co/bvDZk5QIga #Alzheimers #Progerin #CellularModel #DrugScreening #Dementia #Tau #Amyloid #Aging #Neuroscience #Pathogenesis @SciReports

NewsMedical's tweet photo. Speeding up Alzheimer's research: Progerin turbocharges cellular models for quicker drug screening 🧠💡🔬 https://t.co/bvDZk5QIga #Alzheimers #Progerin #CellularModel #DrugScreening #Dementia #Tau #Amyloid #Aging #Neuroscience #Pathogenesis @SciReports https://t.co/5ccsqSAVyt

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Hao Yin

@HaoYin20

over 3 years ago

In vivo half-lives of Lamin A & #Progerin in progeroid tissues (🫀/Aorta/Fat) are weeks & months🤯 Lmna C609G🐭-> slow global protein turnover (ribosome, mitochondria, cytoskeleton) Interesting! Important for gene editing therapy @abbybuch bioRxiv 2023 https://t.co/Q3F12KMZKF

HaoYin20's tweet photo. In vivo half-lives of Lamin A & #Progerin in progeroid tissues (🫀/Aorta/Fat) are weeks & months🤯

Lmna C609G🐭-> slow global protein turnover (ribosome, mitochondria, cytoskeleton)

Interesting! Important for gene editing therapy

@abbybuch bioRxiv 2023
https://t.co/Q3F12KMZKF https://t.co/Jhjsr8YyCC

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GeroScience

@GeroScienceAGE

almost 4 years ago

📢New Recommended Reading #Progerin induces a phenotypic switch in vascular smooth muscle cells and triggers #replicationstress and an #aging-associated secretory signature by @CollBonfillN et al. https://t.co/ptjekFs10t #cardiovasculardisease #telomerefragility

GeroScienceAGE's tweet photo. 📢New Recommended Reading
#Progerin induces a phenotypic switch in vascular smooth muscle cells and triggers #replicationstress and an #aging-associated secretory signature by @CollBonfillN et al.
https://t.co/ptjekFs10t
#cardiovasculardisease
#telomerefragility https://t.co/BlO6gBAgSq

Nuria Coll-Bonfill @CollBonfillN

almost 4 years ago

My last paper from my postdoc is finally out! 🍾🥂🥳 Thanks to all for your contributions and to @AHA_Research @AHA for my fellowship #Progeria #raredisease #vasculardisease @gonzalo_lab @Progeria @GeroScienceAGE https://t.co/729QauqqWC

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Chiara de Lucia @DrCdeLucia

almost 4 years ago · Vienna

Come by poster 0670 to hear about @danrock95’s new #progerin #ageing model! #ecnp2022 @ECNPtweets

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Nature Medicine

@NatureMedicine

over 5 years ago

Optimized #antisense #oligonucleotides that can reduce #progerin tissue expression in vivo pave the way for development of a novel therapeutic approach for Hutchinson-Gilford progerin syndrome. #ASO #GeneTherapy @NCITomMisteli @NIH https://t.co/2NSewN7CCz

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Nature Medicine

@NatureMedicine

over 5 years ago

Optimized #antisense #oligonucleotides that can reduce #progerin tissue expression in vivo pave the way for development of a novel therapeutic approach for Hutchinson-Gilford progerin syndrome. #ASO #GeneTherapy @NCITomMisteli @NIH https://t.co/2NSewN7CCz

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Nature Medicine

@NatureMedicine

over 5 years ago

A modified antisense oligonucleotide that blocks pathogenic splicing of progeria transcripts reduces the production of #progerin in key target organs and extends animal lifespan in a mouse model of #progeria syndrome. #ASO #Genetherapy @NIHDirector https://t.co/EJwlPEVVFb

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K Wary @KishoreWary

over 7 years ago

JCI - #prematureaging #myocardialinfarction #Endothelial #progerin expression causes #cardiovascular #pathology through an impaired #mechanosignaling https://t.co/ua2ZnHrBDx

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ClinicalCaseReports @ElsaReeth

about 8 years ago · United Kingdom

#Progeria : Research of a rare #genetic disease #progerin #clinicalresearch #Medical #casereports #ChildCare4All #Healthcare #PalliativeCare #hospice #eHealth #DigitalHealth #onmedic #Retwet #twitter https://t.co/6cyUCIIgWM via @ElsaReeth

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Vasculometabolic Med @vasculomet_med

over 8 years ago

@Primary_Immune @Progeria Thanks for making me aware of this interesting paper. Original research here: A Cell-Intrinsic #Interferon-like Response Links Replication Stress to Cellular #Aging Caused by #Progerin. #HGPS #Progeria #Calcitriol #ReplicationStress #STAT1 #IFN #LamininA https://t.co/Fgpd5lDIm5