Top Tweets for #Serologic
Elevated #Serologic #Markers Insufficient to Diagnose #Celiac #Disease: while very high tissue #transglutaminase #immunoglobulinA is 94% accurate for predicting histologic disease, not all high-testing patients have #biopsy-confirmed disease. https://t.co/BfR855WL12
🔥🔥#Serologic and #Clinical Predictors of #Progressive #Pulmonary #Fibrosis in #RA-#ILD Progression
🧐 Study Validity
📋 Study Design: A prospective cohort study, suitable for assessing prognostic factors and disease progression over time.
👥 Population and Sampling: 139 RA-ILD patients meeting ACR/EULAR criteria and CT-based ILD diagnosis. Median follow-up: 2.9 years.
✅ Strengths
🔬 Standardized definitions: Use of validated progression criteria and biomarkers enhances reliability.
📈 Prospective design: Minimizes recall bias and allows temporal relationship assessment.
📑 Multivariable analysis: Improved robustness by adjusting for key confounders like age and sex.
⚠️ Limitations
🔹Generalizability: Results may not apply universally beyond the Korean cohort.
🔹Residual confounding: Smoking or comorbidity data not explicitly included.
🔹Radiological scoring: Potential for inter-rater variability despite independent assessments.
🔹Biomarker thresholds: Lack of detailed cutoff values for clinical application.
📊 Key Findings
1⃣Primary Results:
✅UIP pattern: Strong predictor of progression (HR 2.77, 95% CI 1.40–5.49).
✅ILD extent >10%: Associated with higher risk (HR 3.44, 95% CI 1.91–6.18).
✅Biomarkers: KL-6 (HR 1.39), hSP-D (HR 1.43), MMP7 (HR 1.44), and anti-CCP (HR 1.30) were significant predictors.
2⃣Model Performance:
✅Clinical model: AUC 0.73.
✅Combined model (clinical, biomarker, ILD features): AUC 0.78, indicating strong predictive performance.
🔍Future Research:
Needed to test these findings in broader populations and evaluate interventions targeting these predictors.
https://t.co/RfuMe7YLlG
6/8 "#Serologic #nonresponders might not exhibit a similarly heightened #anamnestic response, but resemble #SARSCoV2 #naive persons, as was observed for 1 #previously #infected #vaccinee who never #seroconverted."
#Serologic #surveillance of #viral #diseases assists in determining their magnitude of impact on human populations and is often used to justify the establishment of #vaccination #programmes aimed at preventing disease🦠
Submit to related #SpecialIssue:
👉https://t.co/vhwDP12BXn
I #spit at the thought
Oh and I like the idea of #saliva for #molecular #antigen and #serologic #diagnostics
On a recent call regarding MPXV, a member of the CDC mentioned that since people do not enjoy having their lesions swabbed, they're looking into "less invasive sample types such as nasopharyngeal and anal swabs".
If only there was a truly less invasive sample type to explore 🙄
Watch the webinar recording of the Corporate Educational Webinar: Ortho Clinical Diagnostics: #Serologic investigations for neonatal and maternal health by Robert Flower. https://t.co/Ax1yDdEzu3 #HDFN #ISBTEducation
Protocols for #serologic and #imaging studies and #AAVvector design and production enable Lindsey George, at @CHOP_Research and her collaborators develop a #genetherapy for #hemophilia A.
Share your methods at GEN Protocols and foster discovery!
https://t.co/jmDT5p1EJi
@bottomlineibd @ericbenchimol No correlation between timing of #antitnf, levels and #serologic response to #COVID #vaccine as demonstrated in a prospective #israeli study of 258 subjects, 185 with #IBD, 67 treated with anti-TNF.
https://t.co/BkYjPphL08
@freund_lab Thank you @freund_lab!
Decreased #serologic responses to #covid #vaccine demonstrated in patients with #IBD treated with #antitnf. @freund_lab demonstrated decreased antibody function. No correlation with drug levels ot interval from #antitnf administration. @HelmsleyTrust
JUST PUBLISHED @JAMANetwork
✔️N=159 kidney #transplant recipients
✔️3rd dose of #mRNA #Moderna #vaccine induced a #serologic response in 49% of kidney transplant recipients who did not respond after 2 doses
https://t.co/NCDyraI98x
#RealTimeCOVID19 @IDSAInfo @HIV_TID @AST_info
ICYMI: 7/22 @CDCgov #ACIP meeting on "Data & clinical considerations for additional doses in #immunocompromised people"
✔️#Serologic testing NOT currently recommended
#RealTimeCOVID19 #antibody @IDSAInfo @SHEA_Epi @ASCO @AST_info #cancer #transplant
Schmidt, @PaulBieniasz et al. describe a variety of assays to rapidly & conveniently measure #SARSCoV2 neutralizing #antibodies & evaluate #serologic immunity by vaccination https://t.co/OIAzVscrtp
From our 2021 #Immunology Collection: https://t.co/3GixZEbalP
From "2020: The Year in Experimental Medicine" https://t.co/ANC9a5iRWO
Using pseudotyped and chimeric viruses, @PaulBieniasz @theodora_nyc & colleagues developed new assays that measure #SARSCoV2 neutralizing #antibodies and evaluate #serologic immunity: https://t.co/OIAzVscrtp
.@PaulBieniasz @theodora_nyc et al. describe assays to rapidly & conveniently measure #SARSCoV2 neutralizing #antibodies and evaluate #serologic immunity conferred by vaccination (https://t.co/OIAzVscrtp). From our collection on #COVID19: https://t.co/N5ixk55VA5
Our #MayoClinic approach to: 1. The problem of deciding the ideal time of #livertransplant based on test characteristics/performance of various #SARSCoV2 #antigen and #serologic tests. 2. The approach to immunosuppression post #OLTX in #COVID19 patient @AASLDtweets @Dev_Sanghavi
Liver Transplant Surgery Post COVID-19 infection....Our experience, with respect to timing of surgery, immunosuppression regimen
@pmorenofranco
@AASLDtweets
https://t.co/Xbz7FKODI8
Schmidt, Bieniasz @PaulBieniasz, Hatziioannou, Weisblum, Muecksch et al. @RockefellerUniv discuss a variety of assays to rapidly and conveniently measure #SARSCoV2 neutralizing #antibodies and evaluate #serologic immunity conferred by vaccination https://t.co/OIAzVscrtp
Definitely need a better
#coronavirus #serologic (#antibody) test.
CDC says:
• “Serologic test results should not be used to make decisions”
• “It cannot be assumed that individuals…are protected from future infection”
https://t.co/IXXSn3gZWr via @mercnews
#serologic assay detects IgG and/or IgM antibodies to the SARS-CoV-2 virus. Because antibodies are part of the body's immune response to infection (and not a part of the virus), antibody testing is not as reliable a means of diagnosing acute infection as PCR or antigen detection.
Here is NCI’s Request for Information on “Strategy for Research in Coronavirus Serology Testing and Serological Sciences”https://t.co/SRQi0R2vam #COVID19 #Coronavirus #serologic #COVID2019 #SARSCoV2
Mayor Rui Moreira was the first one getting tested in our drive-thru #serologic screening facility. Officially, the campaign kicks off next Monday. This is a partnership between #i3S and the Municipality of Porto.
#i3Sresearch #covid19 #PortoPonto #staysafe
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