Top Tweets for #T_CELLS
#cancer #immunotherapy #T_cells #dendritic_cells
🦉 The most interesting result here is that dendritic-cell identity may matter less than dendritic-cell state.
In mouse tumors, neither cDC1 nor cDC2 was automatically an effective T-cell activator.
Tumor-specific CTL stimulation was concentrated in a CCR7+ activated state—and deleting these actDCs weakened spontaneous tumor control, checkpoint blockade and adoptive T-cell therapy.
There is a mechanistic twist. cDC1-derived actDCs primed CTLs through classical cross-presentation, while cDC2-derived actDCs could contribute through “cross-dressing”: acquiring intact peptide–MHC complexes from other cells rather than processing antigen themselves.
That gives cDC2s a more direct antitumor role than the usual cDC1-centric model suggests, although this route depended on tumor type.
The broader implication is useful for drug development: simply expanding dendritic cells may be the wrong goal.
Therapies may need to push them into—and maintain—the right functional state.
The major caveat is equally clear: this is compelling genetic evidence in mice, not yet proof that manipulating CCR7+ actDCs will improve human immunotherapy.
👁️CCR7+ activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity.
👉https://t.co/dxH6abkOAB
Engineering #NK and #T_cells with #metabolite-sensing receptors to target #solid #tumors: https://t.co/bz2RyPXFw6
#Tea Cells #T_Cells
#भोपाल की कड़क #ठंड में कड़क #चाय पीते पीते शरीर में #Tea_Cells पाई गई। 😂 ☕
#D 197
@drbrajeshrajput @Vasu711 @Kirtishbhat @waghbakriteagrp
Postdoc in T cell Immunology @zielinski_cz
Join our ERC-funded Infection Immunology lab to unravel the regulation of human tissues resident T cells.
To read the full job description and apply, see link in the thread!
#immunology #systems_immunology #t_cells
#ScienceJobs
Postdoc in T cell Immunology @zielinski_cz
Join our ERC-funded Infection Immunology lab to unravel the regulation of human tissues resident T cells.
To read the full job description and apply, see link in the thread!
#immunology #systems_immunology #t_cells
#ScienceJobs
Postdoc in T cell Immunology @zielinski_cz
Join our ERC-funded Infection Immunology lab to unravel the regulation of human tissues resident T cells.
To read the full job description and apply, see link in the thread!
#immunology #systems_immunology #t_cells
#ScienceJobs
🚀 Major advancement in #space_research and #Immunology!
@NASA, @MDAndersonNews, @Axiom_Space, and @BioServeST are launching a project to study #T_cells on the #ISS. 🛰️ By examining how #microgravity impacts these #immune_cells, this #initiative aims to drive breakthroughs in #cancer treatment and immunology. Leveraging #AI and advanced #technologies, the project promises to push the boundaries of #medical_science. 🌌🔬
#SpaceResearch
#MedicalInnovation
https://t.co/t5D8x872Bk
🚨 New research by @wilfredo_nk published @CellCellPress reveals how #SARS_CoV_2 cleverly evades our #immune_system! His team at #Massachusetts_General_Hospital discovered that the #ORF6 protein helps the virus hide from #T_cells and #natural_killer_cells by shedding crucial surface markers. This stealth move boosts viral 🦠 spread, but stopping ✋ this trick could supercharge our immune defenses and lead to better #treatments.
@MassGeneralNews
#COVID19
#ImmuneEvasion
#ScienceNews
https://t.co/0I8AVoCDnn
#حقائق_مناعية
تشير العديد من الأبحاث أن قلة #النوم تقلل من قدرات #الجهاز_المناعي لمكافحة الأمراض وذلك من خلال التأثير على تكاثر الخلايا المناعية مثل الخلايا التائية (#T_cells) و الخلايا القاتلة الطبيعية (#NK_cells)
"حتى ولو لليلة واحدة فقط"😱
أضف إلى ذلك، أن اللقاحات تصبح أقل فعالية لدى الأشخاص الذين ينامون أقل من ٦ ساعات في اليوم مقارنةً بالأشخاص الذين يحصلون على ساعات نوم أطول وذلك وفق ما أشارت إليه الدراسة التي نُشرت مؤخراً في مجلة @CurrentBiology مما يشير إلى ضعف الاستجابة المناعية. 👎🏻🦠🤒
#بالمختصر 👇🏻
"جهازك المناعي مرهونٌ بنومك الكافي" 😴💪🏻
#T_cells can be too active. Research led by @sjturn & Dr Brendan Russ (1st author) published in @CellReports has found 2 molecular switches to ramp down CD8+ T cell activity, & has generated a detailed genetic blueprint for enhancing T cell function. See https://t.co/ya1ozguzAm
Our new study that looks at how chromatin is reorganised during virus-specific CD8+ T cell differentiation. Big shout out to Dr Brendan Russ, and our collaborators @GoldrathLab @KalliesLab @MonashBioinfo @MonashBDI @Monash_FMNHS
https://t.co/jAdXYgUEin
Way to go, #Dendritic_cells💪🏻, #DC, in love 😍 to play with #T_cells at different levels in the context of “crosstalk” to shape two T cell-associated checkpoints in #antitumor_immunity. More of this can be found @ImmunityCP.
#immunity
#immune_crosstalk
#cancer
#CancerResearch
https://t.co/UJMPvHZTFp
@Burek2Dan @spindezine @EnemyInAState It's not the flu nor will it ever be like the flu, only the symptoms are comparable it's way more highly pathogenic than seasonal influenza nor does SARS2 🦠 care what season it is
It kills your immune system to #CD4 #CD8 #T_Cells #SARS_CoV_2 #WimdsorOn 🇨🇦🍀
#Pfizer-#BioNTech's #mRNA_vaccine for #COVID_19 induces far more circulating immune cells aimed at virus-infected cells than getting infected does. #Stanford #T_cells @NIHDirector @MarkMDavis4 @pfizer
https://t.co/BxnmAGC3rw
Current and future perspectives on CAR-T cell therapy for renal cell carcinoma: A comprehensive review
open access🌷https://t.co/pF0kpCHw47
Investig Clin Urol. 2022 Sep;63(5)Tae Jin Kim
#Immunotherapy #Metastasis #Receptors #chimeric_antigen #Renal_cell_carcinoma #T_cells
Viral persistence inside SARS-CoV infected epithelium reservoirs will cause exhaustion of SARS-CoV-specific CD8+ T-cells in #LongCOVID patients. Mounting evidence that @fitterhappierAJ has been right all along.
https://t.co/nH1wFxMxLg
An excellent collection into #T_cells #immunity Thanks @Nature #Immunology #Immunotherapy #immune_cells #tumor_immunity #viral_immunity https://t.co/4FH8qXhPQE
MS patients getting vaccinated requires reconsideration! @FrontImmunol showed new insight into solid T cell immune response independent of B cell depletions after mRNA vaccination. #Immunology #MS_patients #T_cells #B_cells #COVID #vaccines https://t.co/yeDFP1v8dk
Just one more day to apply for this 4 year post doc position in our lab. #Immunology #vaccines #VaccineResearch #T_cells #flowCytometry
#jobFairy 👇🏼
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