#TumorTesting - Twitter Hashtag

9 months ago

More data supporting #universal #germlinetesting & #tumortesting in #patients w/ #Cancer c/w https://t.co/T7ZR1hr7X0 @ASCO @VivekSubbiah @kurzrock

JCO Precision Oncology

@JCOPO_ASCO

9 months ago

Germline Findings From Tumor-Only Comprehensive Genomic Profiling in the RATIONAL Study: A Missed Opportunity? Co-authored by @NicolaNormanno. Read the full article. https://t.co/Mqpi9sTHkH

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Genetics in Medicine @GIMJournal

almost 2 years ago

This report discovers how pseudogene PMS2CL can skew the frequency distribution of a PMS2 variant in individuals of African genetic ancestry https://t.co/hEW9j3sf9y #GIMO #PMS2 #LynchSyndrome #PMS2CL #Pseudogene #PseudogeneInterference #TumorTesting #GermlineGeneticTesting

GIMJournal's tweet photo. This report discovers how pseudogene PMS2CL can skew the frequency distribution of a PMS2 variant in individuals of African genetic ancestry https://t.co/hEW9j3sf9y #GIMO #PMS2 #LynchSyndrome #PMS2CL #Pseudogene #PseudogeneInterference #TumorTesting #GermlineGeneticTesting https://t.co/mOaPetHehL

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CaRE2 Health Center @CaRE2HEC

almost 3 years ago

Join USC for a discussion and share your thoughts as a community expert on their new Health Education Toolkit! Register in advance: https://t.co/VgkKYRI2B0 #CaRE2HEC #Community #HealthEducation #Cancer #GeneticTesting #GeneticCounseling #TumorTesting

CaRE2HEC's tweet photo. Join USC for a discussion and share your thoughts as a community expert on their new Health Education Toolkit!

Register in advance: https://t.co/VgkKYRI2B0

#CaRE2HEC #Community #HealthEducation #Cancer #GeneticTesting #GeneticCounseling #TumorTesting https://t.co/J2laFO1Txk

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Ed Esplin, MD, PhD

@EdEsplin

about 3 years ago

Clinical implications of missing #germlinevariants in #patients w/ #tumortesting -#TargetedTherapy e.g. #HRR genes & #PARPi -Screening & risk reduction for second primary cancers -Screening & risk reduction for family members #Germline #genetictesting for all #patients w/ #tumortesting? #DrBryanSchneider @IUMedSchool @ASCO #ASCO23

EdEsplin's tweet photo. Clinical implications of missing #germlinevariants in #patients w/ #tumortesting

-#TargetedTherapy e.g. #HRR genes & #PARPi
-Screening & risk reduction for second primary cancers
-Screening & risk reduction for family members

#Germline #genetictesting for all #patients w/ #tumortesting?

#DrBryanSchneider @IUMedSchool @ASCO #ASCO23

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Ed Esplin, MD, PhD

@EdEsplin

about 3 years ago

#Tumortesting misses #germlinevariants in 7-18% of #patients (c/w Lincoln et al. @Invitae @JAMANetworkOpen https://t.co/LkZ1O79HIB) #Germline #genetictesting is gold standard to perform w/ #tumortesting to identify #PGVs #DrBryanSchneider @IUMedSchool @ASCO #ASCO23

EdEsplin's tweet photo. #Tumortesting misses #germlinevariants in 7-18% of #patients
(c/w Lincoln et al. @Invitae @JAMANetworkOpen https://t.co/LkZ1O79HIB)

#Germline #genetictesting is gold standard to perform w/ #tumortesting to identify #PGVs

#DrBryanSchneider @IUMedSchool @ASCO #ASCO23 https://t.co/gdpJxqTAGW

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Ed Esplin, MD, PhD

@EdEsplin

about 3 years ago

Integration of #germlinetesting & #tumortesting crucial for #patients -uncover unanticipated #germline drivers of #cancer -#germlinedirected #precisiontherapy expanding #Germline #genetictesting for all #patients receiving #tumortesting? @@StadlerZsofia @MSKCancerCenter @ASCO #ASCO23 @CGAIGC

EdEsplin's tweet photo. Integration of #germlinetesting & #tumortesting crucial for #patients
-uncover unanticipated #germline drivers of #cancer
-#germlinedirected #precisiontherapy expanding

#Germline #genetictesting for all #patients receiving #tumortesting?

@StadlerZsofia @MSKCancerCenter @ASCO #ASCO23 @CGAIGC

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CGA-IGC

@CGAIGC

about 3 years ago

3/🔎Design 📍Prospective #GermlineTesting Implementation Study 📍Enrolled newly diagnosed #CRC #patients between 18-50 📍#Universal #tumortesting for MMR was performed 📍#Universal #germline #genetictesting was completed using 47 gene panel #HereditaryGICancer

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SOPHiA GENETICS @SOPHiAGENETICS

over 3 years ago

Don't miss our webinar on somatic RNA variant calling presented by Miling Wand, PhD, Bioinformatics Manager, at the Cancer Genomics Consortium Congress in St. Louis. Watch on-demand: https://t.co/71Xy6uaymy #webinar #variant #genomics #rna #ngs #tumortesting #ClinicalResearch

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Ed Esplin, MD, PhD

@EdEsplin

almost 4 years ago

#Universal #germline #genetictesting all #patients w/ #endometrialcancer saves $17M/year over current standard of care (#universal #tumortesting) not including the add'l BRCA1/2 carriers it identifies. @gynoncjnls @HHampel1 @David_Cohn_MD https://t.co/6RqYj0KttU

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Ed Esplin, MD, PhD

@EdEsplin

almost 4 years ago

18% of PGVs in #patients w/ #germlinetesting missed by #somatic #tumortesting, 90% of which changed management, Pauley et al. @ESMO_Open https://t.co/D4XawVnUgW c/w Lincoln et al. @Invitae @JAMANetworkOpen https://t.co/LkZ1O7riA9 #Universal #germlinetesting w/ all #tumortesting

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Ed Esplin, MD, PhD

@EdEsplin

about 4 years ago

"Integrating #Germline, #LiquidBiopsy and #Cancer #TumorTesting" #patient #access #precisionmedicine #precisiontherapy #clinicaltrials #precisionprevention #TCED @PMWCintl

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Ed Esplin, MD, PhD

@EdEsplin

about 4 years ago

#ASCO22 poster preview-integrated #somatic #tumortesting & #germlinetesting in pan-cancer #patients, 93% had #somatic mutation origin resolved by #germlinetesting, #somatic + #germline = more therapeutic targets #DrKingshukDas @Invitae @ASCO https://t.co/focdgYEIq3

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Inherited Cancer Registry (ICARE) @inheritedcancer

almost 5 years ago

Visit https://t.co/qRS7zqCVTY to check out an excerpt from our January 2021 #ICARE Genetics Case Conference, which focused on #tumortesting and germline significance with guest expert @benhopark from @VUMChealth #FridayFacts #inheritedcancer #genetictesting #education #gcchat

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Ed Esplin, MD, PhD

@EdEsplin

about 5 years ago

@sbarnettARK @TheACMG provided guidance in @GIMJournal. To wit, #tumortesting ≠ #germlinetesting, in #tumortesting reporting [presumed germline pathogenic variants]... should be considered, w/ recommendations for...confirmatory #germlinetesting Full PTC... https://t.co/ykRgAKmYCT

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Lisa Moran @plh4lisa

over 5 years ago

Sending positive thoughts to #BobDole. Hoping for the best possible care, treatments and his #lungcancer has been tested for mutations. #lcsm #tumortesting

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Ed Esplin, MD, PhD

@EdEsplin

over 5 years ago

@jamienholloway @itsnot_pink @StoverLab @MarkRobsonMD The wide variability of #germline results returned by #somatic/#tumortesting providers, (if at all!) is a key issue recently addressed by @TheACMG, https://t.co/ykRgAK5nej

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Ed Esplin, MD, PhD

@EdEsplin

over 5 years ago

In this cohort #germline "reflex" testing occurred after #somatic/#tumortesting. The ideal for #patients... simultaneous paired tumor/germline testing, w/ data fully integrated, so each informs the interpretation of the other, maximizing #clinicalutility & patient benefit...

Brittany Bychkovsky, MD @DrBBychkovsky

over 5 years ago

An important study looking at paired germline-tumor testing in pts with cancer: among 2023 pts with cancer, 30.5% harbored PGVs and 8.1% were missed on tumor genomic testing. 11.2% of cohort had germline testing after their 2nd cancer diagnosis. @EdEsplin https://t.co/812iBr6dm6

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Med by Cell Press @MedCellPress

over 5 years ago

Thrilled to have @Dr_R_Kurzrock on our Advisory Board! Dr. Kurzrock is an expert in #RareTumors and #PrecisionMedicine, using molecular #TumorTesting to match each patient with the best possible treatment. Looking forward to our collaboration!