Top Tweets for #atf4
🚀Targeting #ATF4 in Elderly #KRAS #LungCancer
Age reshapes tumors: slows growth but boosts metastasis via integrated stress response (ISR). ATF4 drives plasticity; targeting ISR-ATF4 blocks spread&exposes glutamine vulnerability.High ATF4 links to poor survival—promising target.
📰New & Featured | 🧠 New #Cell study: Cancer hijacks pain-sensing neurons to suppress immunity.
⚙️Through the #ATF4-SLIT2-CGRP pathway, tumors reprogram lymph nodes into an immune-suppressed state.
Blocking this loop or using migraine drug rimegepant can restore anti-tumor immunity.
👉Read more: https://t.co/lUF5TQoBw5
#CancerResearch #Immunotherapy
Glutathione (GSH) drives cancer metastasis by promoting cell survival under hypoxia [https://t.co/8ZI2WHVyjl] #ATF4 #cancer #glutathione #GSH #GSSG #hypoxia #lactate #metastasis #raypeat #idealabs #idealabsdc
Naturally occurring small molecules with dual effect upon inflammatory signaling pathways and endoplasmic reticulum stress response https://t.co/4KINmfY1hj @UPorto @laqv_requimte #IL_6 #TNF_α #IL_1β #ATF4 #CHOP #Caspase_1
Research Article by @VCSanfran and @dhood_york (@YorkUniversity) Acute #contractileactivity induces the activation of the mitochondrial integrated #stress response and the transcription factor #ATF4
🔒https://t.co/vHDir6CA47
Research Article by @VCSanfran and @dhood_york (@YorkUniversity) Acute #contractileactivity induces the activation of the mitochondrial integrated #stress response and the transcription factor #ATF4
🔒https://t.co/vHDir6CA47
A new Science #Immunology study highlights how #ATF4 drives effector gene expression in liver regulatory T cells (#Tregs) and promotes their differentiation from lymphoid precursors in mice. https://t.co/oHQEkPyHDS
Fine-Tuning of ATF4 DNA Binding Activity by a Secondary Basic Motif Unique to the ATF-X Subfamily of bZip Transcription Factors | Biochemistry https://t.co/Qz0LTjUZa9
#ATF4 #TranscriptionFactor #NMR #Protein #DNA
Our new paper modelling #mitochondrial disease in Drosophila is now available. UPR and #ATF4 activation in the brain depends on the severity of mitochondrial complex I loss. https://t.co/n6FgPpBx5Q
Dr. Christopher C. Glembotski et al. commented on an article by Dr. Statzer et al., which the study provided exciting evidence for the possible roles of #ATF4 and #H2S in promoting #longevity.
https://t.co/DfGdNekUZB
New in @ajpendometab! Endoplasmic reticulum stress in pancreatic β cells induces incretin desensitization and β-cell dysfunction via #ATF4-mediated #PDE4D expression (Ji-Hye Lee @LeeFormica73 et al.)
https://t.co/X7JhKOlxed
#IncretinResistance #ERStress
📢New Open🔓Access Paper
Induction of proteasomal activity in mammalian cells by lifespan-extending tRNA synthetase inhibitors by Blaise L. Mariner et al.
https://t.co/rHy7sWIdFt
#gcn4 #ATF4 #trnasynthetase #ubiquitinproteasome #lifespan
@blaisemariner @UNMHSC
happy to see this out!
- congratulations to the first author #JuliaKress on this cool work just published in @CellReports
#nrf2 #atf4 #melanoma
https://t.co/XK5sqmtlbD
and members of our group @thamaranxs @AncelyF
@OxfordshireCC bid £7M from @activetraveleng #ATF4 and received 0. For #Bicester we recommended OCC submit the ATE funded @Sustrans concept for the busy central town Launton Road corridor. What did OCC do?
1/3
#OpenAccess
A stay of execution: ATF4 regulation and potential outcomes for the integrated stress response
https://t.co/OOG4OH8NW5
@UoDMedicine
Graham Neill @GlennMasson
#ATF4 #IntegratedStressResponse #apoptosis #CellDivision #SynapticPlasticity
New in @ajpgi from @Cordoba_Lab @cordoba_chacon: ATF4-mediated #CD36 upregulation contributes to palmitate-induced #lipotoxicity in #hepatocytes (Griffiths et al.)
https://t.co/fKO9xZZ7e3
#ATF4 #palmitate #PPARγ
RASSF1 is identified by transcriptome coordination analysis as a target of #ATF4
🔗 https://t.co/SrVCf7HUyT
#ProteinFolding #ERstress
Here gene co-regulation was used to reveal associations across genes & predict biological function in genetically diverse samples
RASSF1 is identified by transcriptome coordination analysis as a target of #ATF4
🔗 https://t.co/SrVCf7HUyT
#ProteinFolding #ERstress
@peterlim89
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