Top Tweets for #cdk4
🚨EU approves a new endocrine strategy (#camizestrant) for ESR1-mutated advanced breast cancer
The European Commission has approved camizestrant + #CDK4/6 inhibitor for patients with #HR+/#HER2− advanced breast cancer who develop an emergent #ESR1 mutation during 1L endocrine therapy.
💡In the Phase 3 #SERENA-6 trial, switching to camizestrant significantly improved median PFS (16.0 vs 9.2 months; HR 0.44).
📰 Read more: https://t.co/ULla8B6AZv
#BreastCancer #ESR1 #CDK #EndocrineTherapy #PrecisionOncology #CancerResearch
Nancy Lin, MD (@nlinmd), presents on ER+ Metastatic Breast Cancer: #SERDs, #CDK4/6, #PI3K, and novel endocrine agents at the #DanaFarberBreastCancerCourse.
#MBC #BreastCancer
ICYMI: Is there anything to suggest that metronomic #chemotherapy could be effective when combined with #CDK4/6 therapy? #oncology @ASCO #ASCOReadingRoom
Read more: https://t.co/jqa97wRcTf
🌿ASCO2026で肉腫のプレナリーが開催されます✨️
#ASCO2026 #肉腫 #脱分化型脂肪肉腫 #CDK4
🌻演題名: 『進行期脱分化型脂肪肉腫に対するCDK4阻害薬（アベマシクリブ）の有効性・安全性に関する第3相臨床試験』
⏰日時: 5月31日（日）13時39分〜（日本時間: 6月1日3時39分）
・発表者: Mark A. Dickson, MD
（Memorial Sloan Kettering Cancer Center）
🔶脱分化型脂肪肉腫（DDLPS）はMDM2、CDK4増幅が特徴です。CDK4/6阻害剤（アベマシクリブ） の効果を検討した初の大規模第3相試験結果の発表です
👀ASCOプレナリー選出は肉腫領域では極めて稀で、治療のゲームチェンジャーになる可能性が高い注目トピックです。
・標準治療が変わる可能性がある
・臨床的インパクトが大きい
・統計学的に明確な結果が出ている…
とASCO側が判断した演題が選ばれることが多いです。特に肉腫領域の採択は非常に稀です。
Today’s #Pfizer release for the #atirmociclib (#FOURLIGHT-1) trial is a significant clinical signal, but the real value lies in the strategy it validates: the "Molecular Switch." By targeting selective #CDK4 inhibition, Pfizer achieved a 40% reduction in the risk of progression or death (HR = 0.60, p=0.0007) in patients who progressed on prior #CDK4/6 within just 3 months.
This drug differs fundamentally from the "Big Three" (palbo, ribo, abe) because it is CDK4-selective. By sparing CDK6, it avoids heavy bone marrow toxicity that often causes treatment delays (only 6.4% discontinuation rate), suggesting a gentler safety profile.
However, the critique remains: we are still delaying resistance, not eliminating it. The next challenge is identifying which patients benefit from this selective approach versus those who should proceed directly to an ADC.
#BCSM #breastcancer @ASCO @OncoAlert
Pfizer Announces Positive Topline Phase 2 Results for Next-Generation CDK4 Inhibitor, Atirmociclib, in Second-Line Metastatic Breast Cancer - https://t.co/COXDaxEI4I
Great poster spotlight on diverse mechanisms of #CDK4/6 inhibitors this morning @SABCSSanAntonio. Dr. Yuki Matsunaga is trying to intercept cancer cells *before* they can acquire bona fide resistance. #Wnt and #Notch pathways may be involved? #SABCS25 @utswcancer
🙌 hey #sabcs25, be sure to wake up early 🌅 tomorrow (Weds) for Dr. Yuki Matsunaga’s poster spotlight on how drug tolerant persister cells survive treatment with endocrine therapy and #CDK4/6 inhibitors! @utswcancer @UTSWMedCenter @SABCSSanAntonio
Sharpen your treatment planning skills with #CDK4/6i in HR+, HER2- early through metastatic #BreastCancer with Sara A. Hurvitz, MD, FACP, and Carlos H. Barrios, MD. 12/10 at 6:30 PM CST. Produced with @LivingBeyondBC #Oncology #MedEd
🔗 https://t.co/X92afavJui
🆕 In @JAMAOnc ☄️
🎀 TIFFANY trial 🇨🇳
Adding tibremciclib (#CDK4/6i) to fulvestrant significantly improves PFS in HR+/HER2− advanced #BreastCancer 🎀 after ET 💊
🕒 mPFS: 16.5 🆚 5.6 mo
🎯 ORR: 45.6% 🆚 12.9%
✅ Manageable safety
🔗https://t.co/nqZtP7vHUc
@OncoAlert
What Comes After CDK4/6 Inhibitors in HR+ Metastatic Breast Cancer? - Elvina Almuradova
@Dr_ElvinaA @jhaveri_komal
https://t.co/hVVg8uVSKJ
#Cancer #BreastCancer #CDK4 #ADC #MedX #MedNews #MedEd #PrecisionMedicine #ASCO2025 #BCSM #Medicine #Health #Oncology #OncoDaily
The EIPM's Scientific Director Dr. Massimo Cristofanilli (@MassimoCristof9) discusses the early use of #camizestrant with a #CDK4/6 inhibitor to target ESR1 mutations with @cure_today! #breastcancer #precisionmedicine
https://t.co/dpFre3SfU4
Missed #SABCS24? Catch up now at #AACR25! First up: @PedramRazaviMD @MSKCancerCenter: how can we better predict response to #CDK4/6i+ #endocrinetherapy to better escalate/de-escalate therapies? #machinelearning incl clinical + genomic models (both together are better)
🙌 hey #AACR25, don’t miss Dr. Yuki Matsunaga’s poster tomorrow at 2 pm! #singlecellseq #drugtolerance #CDK4/6i #breastcancer @utswcancer
Happy to share our recent @cell_res commentary on a recent @Cancer_Cell paper selective #CDK4 inhibition in #breastcancer. Kudos to to @Mbv26 taking the lead on this and thanks to @rebeccamshulman for input!! Available at https://t.co/8BUy4qVt2z @FoxChaseCancer
🙌Hey @utswcancer @UTSWMedCenter @UTSWCancerBio @UTSWHemeOnc @UTSWScience @UTSW_Pathology don't miss next week's Hamon Center lecture by our postdoc Dr. Yuki Matsunaga, next Thursday on Zoom!
#CDK4/6 #CellCycle #EndocrineResistance #BreastCancer #DrugTolerantPersister #SingleCell
Proud of our latest paper in @jbiolchem showing that inhibiting the mitotic kinase, NEK2, can improve the efficacy of #CDK4/6 inhibitors. Congrats to hardworking @caseccc grad students Jessica Bobbitt and @lessleeeh! @CCLRI #bcsm https://t.co/OMVIdkyNws
At #SABCS24, the @OncBrothers (Drs. Rahul & Rohit Gosain) led a satellite panel with 6 top breast oncologists discussing #CDK4/6 inhibitors, #ADCs, & strategies for shaping breast cancer care in 2025. https://t.co/8RcSlxu3u9 #CDK @DrSGraff @laura_huppert @Neil_Iyengar @curijoey
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