Top Tweets for #eCDNA
Epigenetics Update - An epigenetic program dictates MYC amplification dynamics that promote transient, extrachromosomal, and inherited genomic events https://t.co/sursXSXtoG
#Epigenetics #MYC #ecDNA #KDM4C #SETD2 #Chromatin
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Empower your research at https://t.co/WmSYDGXnzb
🧬 Research Associate (Wang Group) – Cancer Research UK Cambridge Institute
🔗 More Info: https://t.co/W0p02IfCtR
#PostdocPosition #CancerResearch #ecDNA #Epigenomics #Microscopy #UK #CRUKCambridge #CancerBiology #AcademicJobs #GenomeOrganization
In this study, researchers show that RAF1 amplification on #ecDNA drives acquired erlotinib resistance in #NSCLC cells, identifying ecDNA-mediated #Oncogene amplification as a potential #TherapeuticTarget. @skku_official
#STTT #OpenAccess: https://t.co/tYJnQgYZkw
#AACR26
Insightful session on extrachromosomal DNA #ecDNA
EcDNA promotes aggressive tumor growth, intratumoral genetic #heterogeneity, rapid genome #evolution and #treatmentresistance, and is associated with relatively shorter #survival in patients.
@Stanford @StanfordMed
Join us this Sunday at 1PM for the #AACR26 Major Symposium on Extrachromosomal DNA. @anton_gh, @HowardYChang, and I will share new insights into #ecDNA mechanisms, functional consequences, and emerging therapeutic opportunities.
We have another strong day of cancer research discussions ahead at #AACR26! 🧬🔬
On Sunday, join Peter Ly, Ph.D., at 1:05 p.m. as he discusses how intercellular DNA transfer drives the emergence of ecDNA-like elements. You won’t want to miss this discussion!
Do you want to explore how ecDNA promotes cancers and discover novel ways to regulate ecDNA? Please consider joining my lab! We are hiring a talented postdoc! #ecDNA #postdoc #CancerBiology @msupsl
➡️ https://t.co/cVaol20HVj
➡️ https://t.co/TAZb0j5RZ2
‼️Fantastic Visit and Hosts‼️ @StephensonCC grad students invited me & were awesome @OUCollegeofMed. Thanks for dinner, the beautiful gift, discussions, & faculty discussions. Talked about @CeiFccc efforts @FoxChaseCancer & our #ecDNA, #Epigenetic & #DNARearrangement Discoveries!
New work identifies the key sequences that let circular extrachromosomal #DNA (ecDNA) hitch a ride on chromosomes during cell division.
By tethering to chromosomal DNA, #ecDNA carrying oncogenes is reliably inherited — helping tumors maintain high, variable oncogene dosage that fuels growth and therapy resistance.
Source: https://t.co/7UVKmsSkTE
SCI members Paul Mischel & @HowardYChang identify "retention elements" that tether #ecDNA to mitotic chromosomes, aiding oncogene amplification in cancer. These hypomethylated elements ensure ecDNA's generational persistence, aiding tumor growth. https://t.co/2InYnLbREu
SCI member @HowardYChang & others show transposable elements on #ecDNA can act as functional enhancers driving oncogene expression. In MYC-amplified #ColorectalCancer, these elements boost tumour fitness, revealing a new mechanism of cancer evolution. https://t.co/RAgzsY5RrI
Epigenetics Update - Genetic elements promote retention of extrachromosomal DNA in cancer cells https://t.co/yFF11azOYg
Paul S. Mischel and Howard Y. Chang (Stanford University) in Nature
#Epigenetics #ecDNA #DNAm
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Discover the breakthrough at https://t.co/WmSYDGXnzb
No tricks, just treats & great science!🎃
POV: You’ve joined Fusion and the Hilton Tulum team with final preparations for our upcoming conferences! Can’t wait for #SGO25, #ecDNA, #RedoxBio25 & #EREHD25 in the beautiful Tulum.
Extrachromosomal DNA–Driven Oncogene Spatial Heterogeneity and Evolution in #Glioblastoma https://t.co/D6OaMlwEAJ
By @drimrannoorani, @magnushaughey, @mischellab, @CharlesSwanton, @BenjaminWerner_, and colleagues
#ecDNA @QMBCI @UCL @TheCrick @Stanford @CancerGrand
⁉️ 𝗠𝗮𝘆𝗯𝗲 “𝘁𝗲𝗿𝗺𝗶𝗻𝗮𝗹” 𝗱𝗼𝗲𝘀𝗻’𝘁 𝗺𝗲𝗮𝗻 𝘄𝗵𝗮𝘁 𝗶𝘁 𝗺𝗲𝗮𝗻𝘁 𝗮𝗻𝘆𝗺𝗼𝗿𝗲 🌱
Prof. Paul Mischel has spent his life turning loss into purpose, and purpose into discoveries that could redefine #cancer care. 🔬
🧬 His work on extra-chromosomal DNA (#ecDNA) is changing how we understand treatment resistance, and giving new hope to patients once thought out of options.
But his legacy isn’t just in discoveries, it’s in every mind he’s mentored, and every life those minds will go on to save.
Read the full profile article👇
https://t.co/XVlXRLAffc
@mischellab
@oncodaily
@Stanford
@StanfordMed
@StanfordCancer
@BoundlessBio
@Stanford_ChEMH
#CancerResearch #Leadership #Mentorship #ScientificDiscovery #Innovation #Oncology #BoundlessBio #PaulMischel #OncoDaily #CancerWorld #Science
Now online in @CD_AACR: Extrachromosomal DNA–Driven Oncogene Spatial Heterogeneity and Evolution in #Glioblastoma - by @drimrannoorani, Paul Mischel, @CharlesSwanton, @BenjaminWerner_, and colleagues https://t.co/fw5Rzg5GrO #ecDNA @QMBCI @UCL @TheCrick @Stanford @CancerGrand
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