Top Tweets for #optitrop
🔥🚨@OncoAlert Hot off the press.
Just published @TheLancet in conjunction with presentation @ASCO #ASCO26
⭐️Interim Analysis of phase 3 trial;
#OptiTROP-#Lung05 of:
❇️#Sacituzumab Tirumotecan (Sac-TMT)+ #Pembrolizumab Vs #Pembrolizumab in #PDL1+ advanced non-small-cell #LungCancer.
✅#mPFS (Not reached) vs 5.7m (HR 0.35)
✅#ORR 70.2% vs 42.0%
✅Immature #OS data; Positive trend
(HR 0.55)
🔴 ≥ Grade 3 Tx emergent #AEs:
55% vs 31%
👇🏻
https://t.co/OZWx44hNtU
🫁 Sacituzumab-tmt: A new SoC for EGFR-TKI–resistant NSCLC? #OptiTROP-Lung04
The first TROP2 ADC to show significant PFS and OS benefits vs platinum chemo, with fewer serious AEs (7.4% vs 17%) and no ILD.
Could this redefine post-TKI therapy sequencing? Will this become a global standard too?
#CánCare #NSCLC #lcsm #TROP2 #ADC #EGFR #ESMO25
#OptiTROP-Lung04
🫁Sac-TMT (Trop2 ADC) vs Pt doublet in EGFR mutant #NSCLC 2nd line after targeted therapy
mPFS 8.3 vs 4.3months
mOS Not Reached vs 17.4months
No ILD/pneumonitis. G3 Tox similar in both arms
Exciting option, in a challenging setting
#ESMO25 @OncoAlert #LCSM
🔥🚨@OncoAlert Hot Off The Press.
Just published @NEJM in conjunction with presentation @myESMO #ESMO25
Results of:
🎯#OptiTROP-Lung04 phase 3 trial of:
⭐️#Sacituzumab tirumotecan (#TROP2 #ADC) VS #Chemotherapy in advanced #EGFR mutant non-small cell #LungCancer after progression on #TKI
✅Statistically Significant Improvement in:
⬆️ #OverallSurvival (#OS) &
⬆️#ProgressionFreeSurvival (#PFS)
👇🏻
https://t.co/h6947b8bjL
#ASCO25: Oral Abs 8507
#OptiTROP-Lung03 study
#Sacituzumab tirumotecan sac-TMT) in previously treated #EGFR+🫁 vs docetaxel
🎙️Dr Ali Zhang
🔹N=137
🔹ORR 45% vs 15%
🔹mPFS 6.9 vs 2.8
⬆️ AEs- cytopenias, stomatitis, neuropathy
➡️ Based on experience of other TROP2 ADCs unclear if this benefit will hold
#lcsm
@NarjustFlorezMD @Florez_Lab @LatinasInMed @LUNGevity @ABOHLung @lcrf_org @YoungLungCancer @COlazagasti @SraVelazquezOHS @benmlevy @lungsforliving @LungAssociation @lungoncdoc @shrutis_patel @icareforlungs @GO2forLungCancr @EGFRResisters @IASLC @Sam_Kaufman @AnaVManana @ALKPositiveAUS The phase II #OptiTROP-Lung01 trial studied sacituzumab tirumotecan in combination with the PD-L1 inhibitor KL-A167; responses are promising.
@ADesaiMD @LungCancerRx @RManochakian @JackWestMD @lungoncdoc @FawziAbuRous @DevikaDasMD #lcsm may have the plenaries, but #bcsm has 🔥 hot new ADCs!
For abstract no.5️⃣, I OPT for #OptiTROP-Breast01. SKB264 is a new Trop2 ADC with promising ph1 data and multiple ongoing ph3 trials. OptiTROP-B01 is the first ph 3 trial for TNBC. Excited to see the results at #ASCO24!
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