Top Tweets for #sox9
In a new study in @NatureNeuro, a team at @BMCHouston found that overexpressing #Sox9 in astrocytes preserved cognitive function in a mouse model of Alzheimer's disease.
📍 https://t.co/s7FUFFrHn9
転写因子Sox9がAD mouseのastrocyteで貪食受容体MEGF10を制御しAβ plaque貪食促進
Sox9過剰発現は既存plaqueを約50-60%減少させ縦断的行動試験で記憶障害進行を抑制
Sox9は加齢期及びADで特異的に必須だが若齢期には不要という文脈特異的機能
#Alzheimers
#Sox9
#papers
https://t.co/kMkEcgfnmo
☕️In this issue: Villeneuve et al. show coordination of contractile forces in hair follicle development, with #actomyosin contractility and #MechanicalForces from the #epidermis and underlying tissue regulating placode invagination and #Sox9 expression.
https://t.co/sUL4oX5l7e
Faleeva et al found a positive feedback cycle whereby cellular senescence & increased #ECM stiffening promote #Sox9 expression which accelerates #stiffening & #senescence. Learn more about vascular #calcification at https://t.co/bXRTkBDbKP
@FaleevaMaria @scorpionsstart1
💫NEW: Villeneuve et al. report coordination of contractile forces in mammalian hair follicle development, with #actomyosin contractility and #MechanicalForces from the #epidermis and underlying tissue regulating placode invagination and #Sox9 expression.
https://t.co/sUL4oX5l7e
In the only study from India so far to understand the genetics of Adolescent #IdiopathicScoliosis, the first Genetic Predisposition gene #SOX9 has been identified by our group , for an South Asian Indian population cohort (Northwest Indians). Congratulations to all authors especially @Hemender_Singh1
https://t.co/r8JvDZFIQ7
The Art of Science - Cover of Developmental Dynamics
'Tis the season for festive carolers. Sections through the #otocyst, #hindbrain, and #pharyngeal arches of an E9.5 #mouse embryo stained for #SOX2, #SOX9, #TUBB3, and #ECADHERIN. With thanks to Ankita Thawani and Andrew Groves
This landmark study shows the utility of whole-embryo scRNA-seq for molecular and phenotypic profiling of mouse mutants, with genetic defects of the coding & noncoding genome 🧬🧬
Great work from @malte_spielmann 👏👏👏
#structuralvariants #noncoding #SOX9 #ZRS #retina #scRNAseq
Nature research paper: Single-cell, whole-embryo phenotyping of mammalian developmental disorders https://t.co/IfGEwu9OO3
Study finds that #SOX9 is a critical regulator of mucous neck cell differentiation and chief cell #metaplasia. Check out the article here: https://t.co/J08mgfyWa7 @sgwillet @millsjc67
🧋NEW: @ElaineFuchsLab & co show that the #pioneerfactor #SOX9 regulates the #epidermal #stemcell to #HairFollicleStemCell switch by binding and opening hair follicle #enhancers, while recruiting #epigenetic factors away from epidermal enhancers.
https://t.co/kRw3u6YIhG
NEW PUBLICATION! I am thrilled to share our latest publication on @NatureCellBio, addressing how a single pioneer factor, #SOX9, switches epidermal stem cell fate to a hair follicle and later a basal cell carcinoma fate. https://t.co/tWr9MTi4Dh
New @OncologyTube video featuring @NilaySethi, MD, discussing the potential role of the protein SOX9 in enabling a molecular reversal that could lead to the treatment of colorectal cancer. Watch Here: https://t.co/pPCTrm8Zf4 @LabSethi @DanaFarber #SOX9 #ColorectalCancer
⏰ #Sox9 can enable "molecular time travel" and may be a promising therapeutic target for #ColorectalCancer, according to a new @ScienceAdvances article from a team at @DanaFarber.
@LabSethi
📍 https://t.co/9ZKidaaTkp
How is #selfrenewal of #intestinal #stemcells at the crypt base regulated?
Zusen Fan and coworkers identify #circBtnl1 circular RNA #circRNA that inhibits ISC self-renewal via mRNA decay of #Sox9 transcription activator #Atf4
https://t.co/4rwASHP4L8
#Amami #spinyrat males lack the #Ychromosome and #sry gene, but develop #testes due to the upregulation of #Sox9 gene: first report of sry-independent #sexdetermination in #mammals
Read more 👇
#Enh14 #evolution #developmentalbiology #science #research #HokkaidoUni #北海道大学
Excellent presentation 👏👏 Spoken session S107 #BTSWinter2022 Well done Laurence @LPearmain 🫁 Very proud of our #ILD Team @WythenshaweHosp & University of Manchester @OfficialUoM 🇬🇧 #SOX9 #fibroblasts #ECM #IPF #PulmonaryFibrosis #PostCOVID #biomarkers #teamwork
Dormant #SOX9-positive cells facilitate #MYC-driven recurrence of #medulloblastoma.
https://t.co/PkdtjSr5O0
#btsm @CR_AACR
#Organoid-based CRISPRi screen and #SOX9-targeted DamID shows how SOX9 primes human fetal lung tip
progenitors to receive WNT and RTK signals
@LabRawlins @Cambridge_Uni @GurdonInstitute
https://t.co/8OMvolSOFZ
The labs of Drs. B #Deneen, D Sarvar, HChi-Eileen-Chen, @DoctorGRao, S. Mack et al are unraveling the pathways that regulate #brainTumor behavior #sox9 @PNASNews @BCMNeurosurgery @BCMGradSchool https://t.co/qThNhbdD0Q via @bcmhouston
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