Top Tweets for #strem2
Stellar review of our current knowledge surrounding #sTREM2 in neurological disease. Still much to figure out
Soluble TREM2: Innocent bystander or active player in neurological disease
https://t.co/5gHuC5sqid
plasma #sTREM2: a potential marker of #cerebrovascular injury in #neurodegenerative disorders.
In this scientific commentary, @elenarv and I explore the recent publication in @Brain1878 by Tsai et al.
https://t.co/BfNmGaQDde
Thanks Samuel Martinez Meza PhD @EinsteinMed @MontefioreNYC #Pathology postdoc for excellent talk re: Role of #sTREM2 in #HIVneuropathogenesis @yokoda_md #HIVassociatedneurocognitivedisorder #PathEd #macrophage #cytokyne #astrocyte #BloodBrainBarrier 🔬🩺👏
#Microglia and #neuroinflammation #biomarkers sTNFR1-related proteins and #sTREM2 are associated with #Alzheimers prognosis in a stage-specific manner
in @NatureComms
👇🏽👇🏿👇👇🏻
https://t.co/hDdgcOvrZR
Some of these associations were modified by #AD risk factors such as age and #sex, but not by #APOEe4 allele. Particularly, women had higher coupling between amyloid and #sTREM2, a marker of #microglial activation. And tau-amyloid association was stronger in older participants
Happy to share our new paper out in @MolNeuro: We show that higher #sTREM2 is associated with attenuated effects of #APOE4 on cognitive decline and neurodegeneration.
Many thanks to @M_SuarezCalvet @timothyjhohman
@MichaelEwers12
and many others! #endalz
https://t.co/pNO4ZDZrj5
M Ewers, @nfranzme & coll @LMU_Muenchen @DZNE_de @DZNE_en @ISDneuroimaging report that higher microglia activation as determined by CSF #sTREM2 or #microglia PET, shows protective effects on subsequent #amyloid accumulation
https://t.co/hSHvvwoAzf
Happy to share my first paper as "senior author" out now in @EmboMolMed: In AD patients and amyloid-mice, we show that higher #sTREM2 and #microglial activation may slow-down #amyloid accumulation rates, supporting a protective role of #sTREM2. https://t.co/NSiItjZxLN
#ENDALZ
Importantly, #Alector AL002c anti-human #TREM2 antibody:
-Is safe in a phase I clinical trial
-CSF #sTREM2 as a target engagement biomarker?
Congrats Shoutang Wang, @meerkmustafa , Tina Schwabe, Marco Colonna and colleagues! 👌
More insight (and complexity) into the function of #TREM2 and #sTREM2 - has sTREM2 a protective role? #Alzforum #Alzheimers #Microglia
https://t.co/3tHA9xokRs
Freed from the membrane, soluble TREM2 rallies microglia to consume plaques, restore synaptic function and memory. @MayoClinic #sTREM2 #Alzforum https://t.co/FAXMZUExnP
Freed from the membrane, soluble TREM2 rallies microglia to consume plaques, restore synaptic function and memory. @MayoClinic #sTREM2 #Alzforum https://t.co/FAXMZUExnP
CSF #sTREM2 in #Alzheimer using the #ATN classification - see our new paper in @MolNeuro, a collaboration between @ADNI3study @karchlab @ccrugom @PennAging @ISD_Research and @DZNE_en - many thanks to all!
Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology https://t.co/2Hoec7mlYN
New issue @EmboMolMed, as always all articles are #openaccess: #glioma, #PARP1, #Leukemia, immune checkpoint blockade, TUBB1 mutations, #MitochondrialDisorders, #Alzheimer’s disease #sTREM2 & last but not least, eye & #muscle #regeneration (our cover)
--> https://t.co/8uySYoxnov
Two #microglia proteins, #progranulin and #sTREM2, increase together in #Alzheimer's disease. See our new study in @EmboMolMed!
Many thanks to @ADNI3study and DIAN (@WUSTLmed) initiatives!
--> read here: https://t.co/9Q7CoFKEgH
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