Meer Mustafa

interested in using single cell methods, functional screens, computational biology, genetics to build therapeutics. data scientist at @BigHatBio

[Meer Mustafa @meerkmustafa]

I’m riding the Tour de Fox Parkinson's Bike Ride bike ride this year in order to raise funds & awareness for a neurodegenerative disease that takes people away too soon - Parkinson’s Disease. We are riding for our father who was diagnosed with PD in 2019 https://t.co/JPBA6aZ0q3

[Women in Statistics and Data Science @WomenInStat]

Today, we’re going to play a game I’m calling “IT’S JUST A LINEAR MODEL” (IJALM).

It works like this: I name a model for a quantitative response Y, and then you guess whether or not IJALM.

1/

[Jonathan Nunn @demarionunn]

in today's @vittleslondon (£) i had a conversation with the brilliant melek erdal on kurdish identity and kurdish food, the fact that the most famous kurd in the world rn is salt bae, and why your favourite turkish restaurant might also be kurdish

https://t.co/Y1VlcRSty7

[Meer Mustafa @meerkmustafa]

@j_sephlevy @Leah_Romm It’s doesn’t take being a lawyer for him to know he’s knowingly lying lol

[NYT Science @NYTScience]

“It will lead to more casual behavior, which will lead to more transmission of the virus, which will lead to more illness, and more illness will lead to more deaths.” https://t.co/8i4j1wIRdy

[Julie Hallet @HalletJulie]

What bias looks like in peer-review 👇 not only did the reviewers think this was appropriate to write, editors considered it appropriate to send and consider in decision-making 🤦🏻‍♀️ Go through 🧵 for more details @enenbee @arghavan_salles @LiangRhea @WomenSurgeons #HerTimeIsNow

[Meer Mustafa @meerkmustafa]

Thanks for covering our anti-TREM2 Alzheimer’s research @10xGenomics !

[10x Genomics @10xGenomics]

In honor of World Alzheimer’s Month, we’re sharing the latest research on Alzheimer's Disease (AD) in our blog. Learn how researchers are using #scRNAseq to characterize non-neuronal cells in AD and evaluate a possible therapeutic candidate. #WorldAlzMonth https://t.co/FYlJFEMTe2

[Andrej Karpathy @karpathy]

"A vegan diet is probably the single biggest way to reduce your impact on planet Earth, not just greenhouse gases, but global acidification, eutrophication, land use and water use,..., far bigger than cutting down on your flights or buying an electric car" https://t.co/MBSiSYj8ZK

[Johanna Joyce Lab @Joycelab]

Excited to share our @ScienceTM study on #gliomas revealing dynamic changes in different tumor-associated #macrophage and #microglia populations during the initial response to radiotherapy & in subsequent disease relapse.
(1/5)
https://t.co/ScBRcxNez4

[Rahul Satija @satijalab]

Our latest w/@NYGCtech, led by @epic_genetix- we perform a pooled CRISPR screen with scRNA+protein readout (ECCITE-seq) to identify regulators of immune checkpoints. We also introduce mixscape, a toolkit to analyze and visualize single-cell screens: https://t.co/r0QmeTwTqb

[Meer Mustafa @meerkmustafa]

@alzforum @WUSTL Thanks for covering our research!

[Meer Mustafa @meerkmustafa]

Thanks @alzforum for covering the results! Alzforum is a great source of information on latest developments in neurodegenerative disorders research - and is a good read also for anybody who wants to get more familiar with the field! I used it countless times the past year.

[Alzforum @alzforum]

In mice, an antibody that activates TREM2 signaling in microglia reduced amyloid plaque toxicity, but not load. In a Phase 1 trial, this approach seemed safe. @WUSTL https://t.co/dcBTDGEUYu

[Marc Suárez-Calvet 🧠🧪 🩺🌈 @M_SuarezCalvet]

In @JExpMed , #Alector AL002c anti-human #TREM2 antibody:

-Activates TREM2
-Induces proliferation of microglia
-Increases transitioning microglia
-Decreases filamentous amyloid plaques and neurite dystrophy

https://t.co/1kdoIMH9Js

[Meer Mustafa @meerkmustafa]

@MatthewTomeny Thanks Matt!!! Great to hear from you.

[Meer Mustafa @meerkmustafa]

Excited to showcase this amazing effort to curtail Alzheimer’s Disease (AD) pathology to the world! We used our AL002 TREM2 activating antibody to understand how microglia change in an AD setting. To do this, we used transgenic mice (5XFAD; carrying mutations in genes 1/n

[Journal of Experimental Medicine @JExpMed]

Wang, Mustafa @meerkmustafa et al demonstrate that mAb specific for the human microglial receptor TREM2 induces #microglia proliferation, ameliorates Ab-induced pathology in mouse model of #Alzheimers & can be given safely in a 1st-in-human clinical trial. https://t.co/zLZ2rPAxOl

[Meer Mustafa @meerkmustafa]

@CaseyBerk I don't blame you. It's quite a lot of lexicon, I've come to learn, in the neuroimmunology field. When that happens, I only read the intro and discussion. Thanks Casey! :)

[Meer Mustafa @meerkmustafa]

@AmedBorn Thanks Nevar!

[Meer Mustafa @meerkmustafa]

Also, a big shoutout to the Alector team who put in immeasurable effort to create these therapies based on what the genetics in humans tell us. I’m very proud to call them all teammates.

[Meer Mustafa @meerkmustafa]

I couldn’t do anything to change his course but I still feel I can change others’. I couldn’t reach these heights without them. Here's to progressive science and making therapies to help those in need. 6/6