Top Tweets for #utDNA
Excellent summary on #NMIBC and #UTUC treatment, diagnostics and biomarkers from #EAU26 by Joost Boormans 👉https://t.co/KdzGBrAOaR
Key takeaways on #NMIBC and #utDNA/urine biomarkers 👇
☑️#Erdafitinib-iDRS shows strong activity as ablative treatment in FGFR-altered IR-NMIBC → 6-month CR rate: 89% + as adjuvant treatment in BCG-treated HR-NMIBC, adjuvant erdafitinib shows → 1-year RFS: 83%
☑️#utDNA highly prognostic → patients #MRD-negative at baseline and week 12 had ~100% 1-yr RFS #THOR2
☑️For HR-NMIBC, strategies that may shape future care are optimized intravesical therapy (e.g. BCG + MMC) + biomarker-guided surveillance
➡️opens promising perspectives for biomarker-guided follow-up and treatment decisions
#NMIBC #BladderCancer #UroOnc @oncodaily @Uroweb @urotoday
Enjoyed debating #Joshlinscott of @MoffittNews on bladder sparing after CCR - not primetime yet but #utDNA and #ctDNA will be 🔑! Studies Coming soon!
@sonpavde @shilpaonc @koshkin85 @alantanmd @OncoAlert @ZakhariaYousef @Parminder1699 @tompowles1
The debates are concluded but the conversations are still going!
Thanks to the faculty and clinicians who made OLN Great Debates in Solid Tumors in Miami a thoughtful, practical exchange on real decision points in solid tumor care.
New York is next!
Sept 26–27
https://t.co/f4oT2L46h2
#OLNGreatDebates #Oncology @Latinamd @KelseyPanMD @arnabguonc @sonpavde
Question remains how we can best integrate a multimodal framework into clinical decision making in #BladderCancer #MIBC
➡️ #ctDNA (systemic risk)
➕ #utDNA (local signal)
➕ MRI (VI-RADS / nacVI-RADS)
➕ Restaging (biopsy + cytology)
@UrogerliMD also addressed the question with @MichvdHeijden about the correlation of utDNA and ctDNA and how positive utDNA assessment could impact follow-up
#GU26 @ASCO @oncodaily @urotoday
Several talks about the role of #ctDNA & #utDNA at #GU26 with key insights from RETAIN, NIAGARA, TOMBOLA & SunRISe-4 and how they could be implemented in bladder-sparing approaches:
🧬 ctDNA is a strong systemic prognostic marker
✅Post-NAT ctDNA positivity → ~10x higher risk of inferior MFS
✅Persistent ctDNA after NAC —> very poor outcomes
✅ctDNA clearance correlates with better survival
🚫 ctDNA does not reliably capture local disease or recurrence 👉💧utDNA very promising:
✅about 80% utDNA+ at baseline
✅Clearance at week 12 associated with pCR
✅NPV ~70–76%, PPV ~84–88%
#BladderCancer #MIBC #ctDNA #utDNA #PrecisionOncology @ASCO @oncodaily @urotoday #BladderPreservation
Several talks about the role of #ctDNA & #utDNA at #GU26 with key insights from RETAIN, NIAGARA, TOMBOLA & SunRISe-4 and how they could be implemented in bladder-sparing approaches:
🧬 ctDNA is a strong systemic prognostic marker
✅Post-NAT ctDNA positivity → ~10x higher risk of inferior MFS
✅Persistent ctDNA after NAC —> very poor outcomes
✅ctDNA clearance correlates with better survival
🚫 ctDNA does not reliably capture local disease or recurrence 👉💧utDNA very promising:
✅about 80% utDNA+ at baseline
✅Clearance at week 12 associated with pCR
✅NPV ~70–76%, PPV ~84–88%
#BladderCancer #MIBC #ctDNA #utDNA #PrecisionOncology @ASCO @oncodaily @urotoday #BladderPreservation
@MichvdHeijden urinary tumor DNA (utDNA) from periop durva #MIBC NIAGARA trial ➡️ baseline utDNA prognostic of EFS & more associated w/pCR than prior #ctDNA findings, 24-mo EFS rates best w/dual neg followed by utDNA+ only & worst w/dual #utDNA + #ctDNA+ pts
@OncoAlert #GU26
🗣️Urothelial Rapid Oral Abstracts #GU26
👉Dr @MichvdHeijden presenting #utDNA #ctDNA inputs w/ peri-op durvalumab on #NIAGARA
🧪 Baseline low vs high #utDNA: EFS (0.65; 0.40-1.04)
🧪 Pre-RC Clearance #utDNA: EFS (0.24; 0.09-0.62)
🧪 Pre-RC #utDNA (+) pCR 72%
🧪 Pre-RC #utDNA (-) pCR 18%
📊 24mo EFS rates
#utDNA (-), #ctDNA (-): 90%
#utDNA (+), #ctDNA (-): 75%
#utDNA (+), #ctDNA (+): 55%
🔑Key Data underscoring roles of🧪utDNA to detect presence of noninvasive disease (<T2N0M0) and 🩸ctDNA to detect presence of invasive/metastatic disease (>T2 N+ M+).
@apolo_andrea @shilpaonc @BourlonMaite @katy_beckermann @bergsa83 @PGrivasMDPhD @AmandaNizamMD @DrKarineTawagi @drenriquegrande @MichvdHeijden @DrRosenbergMSK @Dr_Aggen @OncoBellmunt @yekeduz_emre @PGrivasMDPhD @urotoday @Uromigos
#SunRISe4: #TAR200 (intravesical gemcitabine) + #cetrelimab showed high #pCR (38%) with biomarker potential of #utDNA @AndreaNecchi @TiansterZhang #ESMO25
🔬 Data presented at #ASCO24 by @jlinscott_uro demonstrated that genomic alterations and copy number variations detected in #utDNA can accurately predict #MRD in patients with high-risk #NMIBC.
🧠 Learn More: https://t.co/tFui8e8GaO
Tumor fraction and copy number burden using #utDNA may be an excellent biomarker for minimal residual disease #MRD to be used for surveillance in high-risk #NMIBC #BladderCancer
@jlinscott_uro @UrogerliMD
Great work @jlinscott_uro @UrogerliMD presented at #AUA2024
➡️ Mutations detected by #utDNA concordant with bladder tumor
➡️ Range from single point mutations to chromosomal loss/gain
➡️ Possible tool for MRD detection in #NMIBC
@MoffittNews #BladderCancer
During #AUA24, Joshua Linscott, MD, PhD, (@jlinscott_uro) discusses detecting residual tumors with cell-free urinary tumor DNA in high-risk non-muscle invasive #bladdercancer patients. #CancerResearch
@AmerUrological
Kyle Shanahan 🫱🏻🫲🏾 Steve Sarkisian
Losing their Super Bowl
#UTDNA
#UTDNA 🧬
Kyle Shanahan When Calling Plays in the Super Bowl:
• 0-3 Record
• Outscored 29-74 in 2nd Half/OT
Thanks @Uromigos for showcasing our work with @GrailBio using a methylation based approach to identify bladder cancer with utdna
#utdna may be a very important biomarker to identify and follow patients with bladder cancer. More work coming!
@UCSDCancer_COE @UCSD_Urology @ASCO
Tyler Stewart and urine tumor DNA in NMIBC #GU23
If you’re interested in urine tumor DNA in bladder cancer, please come take a look at our poster using a targeted analysis of methylation-patterns during the poster session!
@OncoBellmunt @MattGalsky @apolo_andrea @PGrivasMDPhD @DrRanaMcKay @Uromigos @aadel_chaudhuri #GU23 #utdna
#proudmentor moment with @KevinChenRT! He did an awesome job presenting his stellar research from my lab @WashURadOnc. #utDNA #ctDNA #bladdercancer #liquidbiopsy #ASTRO21
Thank you @GenomeWeb for highlighting both our @PLOSMedicine stories out today, one in #bladdercancer #MRD using #utDNA, the other in #NF1 #MPNST #sarcoma malignancy vs. benign precursor using low-pass WGS of #cfDNA. https://t.co/gtFCGKcw5t
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