This account explores the science, philosophy, and future of defeating aging, increasing healthspan, and pursuing longevity escape velocity. I advocate for informed consent, voluntary care, and responsible innovation while discussing the ethical, social, and technological paths toward longer, healthier lives. This is for commentary, critical analysis, and educational discussion and does not constitute medical advice.
Slowing aging is not theoretical. In humans, calorie restriction measurably slows biological aging pace by ~2–3% over 2 years
Link here: https://t.co/Eg8wBzhDpQ
biotech is starting to move like AI did 3 years ago
and the smart money is moving fast
- Brian Armstrong's NewLimit just hit a $3.1B valuation
- Jeff Bezos put $3B behind Altos Labs
- Demis Hassabis raised $2.1B for Isomorphic Labs
- Anthropic acquired Coefficient Bio for $400M
- NVIDIA is backing companies building programmable biology
- longevity biotech raised $3.74B in Q1 2026 alone. 56% ahead of Q1 2025.
the interesting part is not the funding
it is what the funding is chasing
for the first time in history we are building tools that can read, model, and modify human biology at scale
Eli Lilly became one of the largest companies on earth from a single peptide category
imagine what happens when the entire stack becomes programmable
the smart money is not speculating anymore
it is positioning
Superhuman Fund II is open for whoever wants in
bio/acc
Aging is arguably the root cause of most major diseases (loss of function in our cells). Four years ago, we made a bet that aging was treatable, and NewLimit was born.
NewLimit now has a prototype drug that reverses the age of some human cells (restores function they had when they were younger), and a clinical trial scheduled for next year (with more drug candidates in the pipeline).
Grateful to Founders Fund, Thrive, Greenoaks, and the rest of the investors for this latest round. @jacobkimmel and the team are just getting started.
“…randomized phase 3 trial published in the New England Journal of Medicine, daraxonrasib gave a median overall survival of 13.2 months versus 6.7 months for standard chemotherapy.”
A smartwatch at the wrist tracks blood pressure as a continuous waveform using tiny electrical changes in blood flow, sidestepping the usual inflatable cuff. @NatureComms https://t.co/FM94gLUrSt
SITUATION DETECTED: Revolution Medicines’ oral cancer drug daraxonrasib nearly doubled survival rates for patients with metastatic pancreatic cancer in a Phase 3 trial.
Anktiva's approval is solid for BCG-unresponsive bladder cancer: ~70% complete responses in trials, many durable (up to 4+ years), via IL-15 superagonist boosting NK cells and memory T cells. Real win for that patient group.
The "most important longevity drug" framing from Soon-Shiong is speculative hype. It targets immunosenescence mechanistically, but zero dedicated longevity trials in healthy people. No evidence it extends healthspan or prevents aging/cancer broadly. FDA has even warned on overclaims.
Promising immunotherapy direction—watch broader trials. Not a quiet longevity revolution yet.
The FDA just approved a longevity drug -- and almost nobody noticed.
Anktiva (an IL-15 superagonist) was greenlit for bladder cancer. But the scientist behind it, Patrick Soon-Shiong, calls it the most important longevity drug of the decade. (1/5)
Are you starting to see it yet?
We will have one-shot cures and preventions for all diseases by 2030.
AI will reach maximum intelligence and ability by 2030.
We will be at the end state of technology by 2030.
I can clearly see now the path to longevity escape velocity Ray Kurzweil has laid out
All disease/aging is just proteomic dysfunction and we're going to completely fix that and abstract it away in the coming 5-10 years
Biology is going to eclipse every other platform
Many people spent a career in relative obscurity to deliver a breakthrough result in cancer care today. Hoping this drug gets to all the patients that need it as soon as possible/yesterday.
i don't think there'll be a definite time when death will be "solved".
it will be an eternal process of progressive knowledge creation, solving ever more and thornier causes of death.
essentially as per David Deutsch, it will be a (personal) "beginning of infinity".