Innis Lab

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[Innis Lab @InnisLab]

A new study by @LeroyElodie3, Thomas Perry and @ThibaudRenault shows how the antibiotic Tetracenomycin X (TcmX) blocks translation of QK motifs by sequestering peptidyl-tRNA. @ERC_Research @iecb_bordeaux @arna_lab https://t.co/7u0z0fzPXF

[Yong Xiong Lab @Xiongosome]

Our high-resolution (2.2 Å) in situ structural work reveals details of translational landscape, with various cofactors and antitumor drug/inhibitor, all directly within human cells!

https://t.co/ScWOAQRjTw

[Kozo Tomita Lab: RNA Biology @RnaLaboratory]

Ribosome meeting 2024 (Dec 2 - 4) at The institute of Medical Science, The University of Tokyo, organized by Prof Inada. @inada_lab .
https://t.co/Fm2jnKfh4v

[CNRS Alsace @CNRS_Alsace]

Toutes nos félicitations ! 👏👏👏

[Innis Lab @InnisLab]

Exciting to see peptides targeting new sites on the ribosome and exerting context-dependent effects through novel means! Congrats to all involved at @WilsonLab2 @shuramankin and @Suessmuth_Lab !!!

[WilsonLab @WilsonLab2]

Our preprint reporting the structure and mechanism of the natural product translation inhibitors paenilamicins is out…completely novel binding site on the ribosome! https://t.co/wCoi8Safjc…great collaboration with ⁦@Suessmuth_Lab⁩ ⁦@shuramankin⁩

[Korostelev Lab @KorostelevLab]

Angiogenin controls angiogenesis (et plus) by nicking tRNAs. But it’s barely active alone. We discovered how 80S ribosome unlocks Ang’s active site and “brings in” tRNAs.
Congrats to Anna Loveland and collab. w/@ajplanetearth!
https://t.co/TZUcT6dEHN

[Rainer Nikolay @RainerNikolay]

Read our latest #research on antimicrobial peptides that inhibit the activity of the bacterial ribosome in multiple ways, published in @NatureComms Thx to all co-authors & the members of the Grubmüller, Hoffmann and Spahn groups. https://t.co/7mKxsw91h1
https://t.co/dVrZMP6Ej5

[Demis Hassabis @demishassabis]

Thrilled to announce AlphaFold 3 which can predict the structures and interactions of nearly all of life’s molecules with state-of-the-art accuracy including proteins, DNA and RNA. Biology is a complex dynamical system so modeling interactions is crucial https://t.co/Gs4GoOB3fD

[nature @Nature]

Researchers have used generative artificial intelligence to help them make completely new antibodies for the first time https://t.co/pcb5is20jF

[WilsonLab @WilsonLab2]

Our structure of SecM-stalled ribosomes out in ⁦@natcomms⁩. https://t.co/yOyiZbI64r. Great work by ⁦⁦@felixgersteuer⁩ ⁦@MartinoMorici⁩ and collaborators, with data collected at the ⁦@CssbHamburg⁩ by ⁦@haaris_safdari⁩

[Innis Lab @InnisLab]

Not one, but two papers on arrest peptides!! What a day! 😍 Congratulations Daniel @WilsonLab2, collaborators and team! 👏👏👏

[WilsonLab @WilsonLab2]

We are rapping today about arrest peptides!! Back-to-back manuscripts in ⁦@NatureComms⁩ showing how RAPP and SecM arrest peptides can stall the ribosome! SecM link here: https://t.co/yOyiZbI64r https://t.co/JqLfk5Kcx9

[CruzVeralab 🧫 🧪 🔬 👨🏿‍🔬 🦖 @CVeralab]

The final version of the most recent paper on the ribosome regulatory TnaC peptide and L-Trp saga is finally out. @gentle_heather @shuramankin

Functional domains of a ribosome arresting peptide are affected by surrounding nonconserved residues - https://t.co/fXsO7CqmYT

[Jue Wang @jueseph]

I wrote a review (with @_JosephWatson @sid_thesci_kid ) on protein design using structure prediction models--i.e. hallucination, inpainting, diffusion. This approach to protein design started as a convenience but has turned out to be surprisingly powerful. https://t.co/bXlKWouQ2J

[Rohith Krishna @r_krishna3]

Our work on modeling and designing biomolecular assemblies is now in @ScienceMagazine.
https://t.co/J0xnuTGGgZ
RFAA Code: https://t.co/PkMLFH9iid
RFdiffusionAA Code: https://t.co/96Ul66ljJe

[Pierre Maisonneuve @Maisonneuve_PhD]

We are #hiring! In collaboration with #Xavier_Guillory, we seek a talented and motivated postdoctoral researcher in #cryoEM to study membrane #kinase receptors involved in human health and diseases.

Please share widely.

https://t.co/0efpc29KSK

[Matthieu Gagnon @gagnon_lab]

We reveal the mechanism of bacterial ribosome recycling by HflXr (and HflX). HflXr employs a novel strategy to split the ribosome into subunits
that differs from that mediated by EF-G and RRF

https://t.co/tENKGKYXtb

[Innis Lab @InnisLab]

@Maisonneuve_PhD @NatureSMB @SinaiHealth @IRIC_umontreal Congratulations Pierre @Maisonneuve_PhD !! Glad to see this out! 👏🍾🥂

[Pierre Maisonneuve @Maisonneuve_PhD]

We are thrilled to share our last #research story @NatureSMB describing how the CNK-HYP scaffolding complex activates RAF kinase by enhancing the KSR:MEK interaction. Great collaborations with the Sicheri lab @SinaiHealth and Therrien lab @IRIC_umontreal

https://t.co/U9ac5uLfAy

[Science Magazine @ScienceMagazine]

Cresomycin—a novel synthetic molecule—demonstrates remarkably robust efficacy against multiple, evolutionary divergent forms of antimicrobial resistance, researchers report in Science.

Read more: https://t.co/qI7gkbus7K

[Innis Lab @InnisLab]

Congratulations Alba! First an HFSP fellowship and now an MSCA fellowship to work on cool new antiviral defense systems @MDMlab_Paris ! 🥳🍾🥂Exciting times lie ahead!!

[Innis Lab @InnisLab]

Congrats Matt @gagnon_lab and collaborators @chillzaa and @SergeyVMelniko1 ! Beautiful work!

[Matthieu Gagnon @gagnon_lab]

We are thrilled to share our new story out @Nature - the discovery of a novel family of ribosome hibernation factors. This is the result of an exciting and stimulating collaboration between three labs @GagnonLab, @SergeyVMelniko1, and @chillzaa
https://t.co/hPRbZNP7fi