Intestinal Cell News

An online resource for intestinal cell researchers. Part of the @STEMCELLTech Science News service.

[Intestinal Cell News @Intestinal_Cell]

Looking for an easy way to stay up to date on all things #IntestinalCell News? 🧐 Check out the Science News website by @STEMCELLTech and subscribe to our regular newsletters covering the latest research, reviews, industry news, and more. 👇

https://t.co/56Pvfh6Hcg

[Intestinal Cell News @Intestinal_Cell]

📢 New research supports CLDN1 as a candidate colorectal cancer-associated marker linked to malignant epithelial-cell states, tumor-associated spatial heterogeneity, invasive phenotype, and Nutlin-3a (−) response.

#OpenAccess👉 : https://t.co/9lcfYE9AEu

#ColorectalCancer #IntestinalResearch

[Intestinal Cell News @Intestinal_Cell]

Metabolic plasticity enables #ColorectalCancer (CRC) cells to adapt to energy stress, contributing to #tumor progression and therapeutic resistance.

💡Results from a study in Biochemical Pharmacology provide mechanistic insight into the #anticancer activity of aripiprazole and support targeting metabolic plasticity as a therapeutic strategy for #CRC!

Find out more: https://t.co/tnQYxPY9VZ

[Intestinal Cell News @Intestinal_Cell]

Findings in this study (@cellhostmicrobe) identify Gemella morbillorum as a candidate onco-pathogen in #ColorectalCancer that uses multiple mechanisms to disarm the #intestinal barrier and trigger genotoxicity.

#OpenAccess🔗: https://t.co/VvB4uYJrVe

[Intestinal Cell News @Intestinal_Cell]

Findings from this study in @NatureMicrobiol reveal #bacterial interactions regulating #intestinal function and a potential clinical therapeutic approach to preventing outcomes of #enterotoxigenic Bacteroides fragilis colonization.

Find out more: https://t.co/gyej4nLAgo

[Intestinal Cell News @Intestinal_Cell]

Data from this study in @sigtrans_sttt reveal a Paneth cell-intrinsic endoplasmic reticulum stress mechanism linking ATZ accumulation to gut epithelial dysfunction, highlighting a previously underexplored role of the gut–liver axis in AAT deficiency.

Read the #OpenAccess paper: https://t.co/EzSYLkEASC

#PanethCell #EndoplasmicReticulum #IntestinalResearch

[Intestinal Cell News @Intestinal_Cell]

Findings from a new study in @cgtnature suggest that targeting the m6A modification pathway holds promise for gastric cancer therapy, as the newly identified METTL3-E2F2-MCU axis plays a key role in regulating mitochondrial calcium homeostasis!

🔗 https://t.co/99E0Ig6Sge

#GastricCancer #IntestinalResearch #Mitochondria

[Intestinal Cell News @Intestinal_Cell]

Researchers from @UChicago built a comprehensive atlas of cell-type-resolved #chromatin accessibility which provides a comprehensive resource to study gene-regulatory effects in #CrohnsDisease and health.

This atlas in @NatureGenet highlights the cellular complexity underlying Crohn’s disease risk.

🔗 https://t.co/q6RMiFCFy8

[Intestinal Cell News @Intestinal_Cell]

Findings from a study in @jlipidres suggest that loss of ceramide synthases 5/6 exacerbate myristate-induced intestinal endoplasmic reticulum stress in colon epithelial cells.

Find out how accumulation of dhsphingosine may provide protection in the #OpenAccess paper here: https://t.co/VpOLgOTcET

#Colon #EpithelialCells #EndoplasmicReticulum

[Intestinal Cell News @Intestinal_Cell]

Study findings reveal an intestinal effector-triggered immunity guard system that couples pore-forming toxin-damage sensing to comprehensive epithelial recovery, with physiological relevance for mucosal homeostasis across metazoans!

Read the #OpenAccess paper here: https://t.co/IXJrzqqC45

#IntestinalResearch #Immunity

[Intestinal Cell News @Intestinal_Cell]

Scientists summarized the key intercellular dialogs that regulate fibroblast-to-myofibroblast transition during the onset and progression of intestinal disorders, further analyzing their regulatory mechanisms.

🔍Read the review: https://t.co/mGFDUoNwpB

#IntestinalResearch #FMT

[Intestinal Cell News @Intestinal_Cell]

Scientists from @PennMedicine present a retrospective review 📝 of #intestinal tract biopsies from patients treated with various cellular #immunotherapies (BCMA and CD19-directed CAR T, teclistamab and rituximab therapies).

🔗 https://t.co/7e8e2SFo9c

#OpenAccess

[Intestinal Cell News @Intestinal_Cell]

Researchers synthesized recent evidence to propose an updated framework for early gastric carcinogenesis based on field evolution, lineage instability, ecosystem support, and pathway divergence.

Check out this review 👀: https://t.co/KuvysyhCzd

[Intestinal Cell News @Intestinal_Cell]

Findings point to the potential of dietary compounds 🥗 to modulate #IntestinalStemCells as a strategy to alleviate colorectal lesions.

Learn more: https://t.co/o0PlabVi63

[Intestinal Cell News @Intestinal_Cell]

🔬 Scientists identified functional zebrafish intestinal #StemCells in the proliferative zone of intestinal furrows that can differentiate into nearly all characterized epithelial cell lineages.

Read the #OpenAccess article in @CellReports here: https://t.co/hi7Yj0BjmQ.

[Intestinal Cell News @Intestinal_Cell]

Scientists from The Chinese University of Hong Kong show that the bacteria Agathobacter rectalis has anti #CRC effects in vitro and in vivo! 🦠

Read more in their #OpenAccess article: https://t.co/aqLymzxPDE.

[Intestinal Cell News @Intestinal_Cell]

Read this review which systematically analyses how cAMP response element modulator facilitates #UlcerativeColitis. 🧐

🔗 https://t.co/5Y9ySi9F8o

[Intestinal Cell News @Intestinal_Cell]

Extracellular vesicles (EVs) from multiple sources regulate intestinal homeostasis and #inflammation. In this review, read how EVs show promise as biomarkers and targeted therapeutics for precision #IBD care!

🔗 https://t.co/1Rnuej4jWH

[Intestinal Cell News @Intestinal_Cell]

🤩 The first patient has been dosed in the phase 1 trial evaluating BHB810, a novel drug for the treatment of #GastricCancer!

🖥️ BHB810 was engineered using @BigHatBio's AI-powered antibody design platform, read more: https://t.co/jav4Y2EZgK

[Intestinal Cell News @Intestinal_Cell]

🩺The @FDA has approved @BeOneMedicines's TEVIMBRA®-based regimen for the first-line treatment of adult patients with HER2-positive (HER2+) gastric, gastroesophageal junction, or esophageal adenocarcinoma (#GEA)!

More info 👉 https://t.co/d8gcCrtaGV

[Intestinal Cell News @Intestinal_Cell]

It's a major challenge to select effective chemotherapy after immunotherapy in #GastricCancer🤔.

That's why scientists at Sun Yat-Sen University created an immune-activated co-culture model of gastric cancer organoids to develop personalized screening strategies!

📖 Read more about this study: https://t.co/wG22bj6dL0