E.S.

I kept learning more and more about less and less until I knew absolutely everything about nothing at all. And for that, they gave me a PhD.

[E.S. @iseethepacific]

Taught my kid basic principles of genetic engineering. Still trying to teach her how to smile for the camera. #futurenerd

[E.S. @iseethepacific]

@BaldKnower the currency was SOL, he should pay you back in SOL

[E.S. @iseethepacific]

@calebarclay I just want a cheap / personal version of this for home remodel planning. Something like that exists? Upload my existing blueprints, then make changes/structal and visualize what I want.

[E.S. @iseethepacific]

@buccocapital *wait until you discover Alexa…

[E.S. @iseethepacific]

@GilbertBelion White Box(s) = faster, cheaper, soulless

[Today In History @historigins]

In 1998, the United States achieved its first federal budget surplus in 29 years, effectively ending a streak of deficits that had lasted since 1969. ⁠
⁠
This milestone was achieved under President Bill Clinton, following the passage of the Balanced Budget Act of 1997, which resulted in a fiscal surplus of approximately $69 billion for that year.⁠
⁠

[E.S. @iseethepacific]

@m_goes_distance tough to do Palantir-for-health… when Palantir is already doing health (one recent example of numerous, if you look): https://t.co/YrYZN1R5Ae

[E.S. @iseethepacific]

@nikillinit my understanding is VSP is both my insurance… and the owner of the 👁️ shops (visionworks, etc) I take my insurance too and get a “discount” at. It seems like I’m basically buying a vision-subscription, branded as “insurance”.

[E.S. @iseethepacific]

@DallasAptGP @_contraryan can i get access to this map? really interested in the locations of WA and OR states.

[Avi Roy @agingroy]

A weekly jab in the belly is generating more revenue than the entire AI industry.

Ozempic + Mounjaro: $71B in 2025.
OpenAI + Anthropic: $29B.

And they've barely started. ~2% of the 800 million eligible patients can currently access them.

h/t @DrSamuelBHume

[E.S. @iseethepacific]

@martyrdison @anothercohen @ThroneScience @ScottHickle wait until he requests to download his data! 📸

[E.S. @iseethepacific]

@patio11 @ankurnagpal *teams like this can help you: https://t.co/K4sl0EKFBH

(I have no relationship with the link above. But I met them once, and subsequently learned about just this)

[E.S. @iseethepacific]

@patio11 @ankurnagpal yes this. And then so same banks will give you a line of credit, collateralized by this now less-risk diversified basket of equity made by you and others like you. It’s a nice idea actually.

[Camus @newstart_2024]

Richard Feynman’s savage takedown of pseudo-science still burns in 2026:

“Social science is an example of a science which is not a science. They follow the forms… but they don’t get any laws. They haven’t found out anything.”

He goes harder:

Experts who “sit at a typewriter and make up” claims — “organic food is better,” “this diet cures everything” — as if it’s settled science, when no rigorous experiments or checks have been done.

Feynman:

“I know what it means to really know something.
How careful you have to be. How easy it is to fool yourself.
I see how they get their information… and I can’t believe that they know.”

The Nobel physicist calls it straight: most of what passes for “expert” opinion is noise dressed up as knowledge.

In an age drowning in TikTok “science,” influencers, and clickbait studies — Feynman’s 1:52 rant feels more relevant than ever.

Who’s the biggest pseudo-expert that grinds your gears right now?

Clip is timeless fire — watch it and feel the clarity.

[E.S. @iseethepacific]

@KYRRadio @bhargreaves stay. Help fund/advocate the challenge to this nonsense. State Constitution and case law will result in a challenge. Income Tax is a failed argument, they might try to call this an excise tax on the privilege of income… but that’s transparent nonsense.

[NBC News @NBCNews]

ChatGPT Health — OpenAI’s new health-focused chatbot — frequently underestimated the severity of medical emergencies, according to a study published in the journal Nature Medicine. https://t.co/DwClepqNZu

[E.S. @iseethepacific]

@EricTopol could one (do they?) weight the HR effect onto the prevalence of each and estimate the burden per 100,000? i.e. a greater absolute effect from CRC vs pancreatic.

[E.S. @iseethepacific]

@buccocapital @AJButton2 this is 100% exactly what will happen. And it’s right to happen.

[E.S. @iseethepacific]

@themoviedadsc but the last 15 of those 20 have been the wildest anomaly of the broadest and longest bill run in history. Random unmanaged of course can win in such a thing. What does it look like in a truly typical 20yr window?

[E.S. @iseethepacific]

@ErikKaiser @trevizo_gabe Rocking chair test: Imagine yourself as an old man, sitting in a rocking chair on the front porch of your house and thinking about this moment you are in. If there’s any chance that in that rocking chair, you’ll wish you had made the hard choice… then make the hard choice today.

[E.S. @iseethepacific]

@NWischoff possibly Debut Bio in San Diego.