Jaime Pascual

6'5 Molecular Biologist, Pharmacist, Law student, Sailor, thinking out of the box,who likes opening windows to get fresh air in my second life. BeYou{tiful}

[Jaime Pascual @Jaimelikes]

#beyourself

[Jaime Pascual @Jaimelikes]

A must

[Dr. Dennis Walker @drdenwalker]

Quercetin is a potent antioxidant and anti-inflammatory. It possesses the ability to inhibit the cyclooxygenase lipoxygenase enzymes, limiting the production and activity of inflammatory leukotrienes and prostaglandins.
#quercetin #inflammation #Allergies #Health

[Jaime Pascual @Jaimelikes]

Another brick on the wall

[Astronomy Vibes @AstronomyVibes]

What if the universe works less like a solid, physical place and more like an enormous video game, only rendering reality in detail the moment someone looks?

This provocative idea comes from Thomas Campbell, a physicist who spent years working with NASA. In his theory, which he calls My Big TOE, short for My Big Theory of Everything, he proposes that reality is fundamentally made of information, and that the physical universe is a kind of virtual reality. Just as a video game does not bother rendering a distant mountain until your character turns to look at it, Campbell suggests the universe may only produce concrete physical detail when an observer requests it.

His inspiration comes from the genuine strangeness of quantum mechanics. In real, verified experiments, tiny particles behave like blurry waves of possibility until they are measured, at which point they snap into a definite state. Campbell takes this famous observer effect and runs with it, arguing that consciousness itself plays a central role, and that the world we experience is essentially data being processed, like a simulation.

Now the essential honesty. This is Campbell's personal hypothesis, not established or accepted physics. The vast majority of physicists interpret the quantum observer effect very differently, pointing out that observation in quantum mechanics means any physical measurement or interaction, not necessarily a conscious mind. There is currently no experimental proof that reality is a simulation or that it vanishes when unobserved. It is a bold, imaginative idea sitting at the edge of science and philosophy.

Still, it taps into a question that has fascinated humanity forever. What is reality actually made of, and does it exist independently of us? Similar simulation ideas have been seriously discussed by thinkers like Elon Musk and philosopher Nick Bostrom, which is partly why the concept keeps capturing imaginations.

Whether or not it is true, it is a genuinely mind bending thought to sit with.

Do you think reality exists completely on its own, or is there something to the idea that observation shapes the world around us?

[Jaime Pascual @Jaimelikes]

One day you read that, another day quite the contrary.

[Smart Science @SmartScience]

Protein maxxing? A major scientific review reveals that reducing protein may be the secret to living a longer, healthier life.

The modern obsession with 'protein maxxing' has flooded grocery shelves with protein-enriched cereals, coffees, and waters, creating a widespread belief that more protein is always better. However, a sweeping new review of more than 350 scientific studies published in Cell Press Blue challenges this nutritional gospel.

Researchers found that, especially for relatively sedentary individuals, lowering protein intake can significantly slow biological aging, improve metabolic health, and potentially extend lifespan.

While athletes and highly active people utilize extra amino acids for muscle repair, those same compounds can cause cellular and molecular damage when consumed in excess by less active individuals.

This scientific synthesis explains that restricting protein triggers key anti-aging mechanisms in the body, such as elevating a crucial metabolic hormone called fibroblast growth factor 21 (FGF21) which boosts energy expenditure and lowers systemic inflammation. This evidence stands in stark contrast to recent updates in dietary guidelines, sparking a major debate among health experts. By demonstrating that protein restriction can yield weight loss, reduced body fat, and improved blood sugar without requiring total calorie restriction, this research suggests that the path to longevity may involve putting down the protein shake and prioritizing balanced, moderate eating.

source: Lamming, D. W. (2026). The Hallmarks of Protein and Amino Acid Restriction in Aging and Longevity. Cell Press Blue.

[Jaime Pascual @Jaimelikes]

Interesante

[parm🔬 @parmita]

ok this is INSANE 😭

cancer cells can become invisible to your immune system. and the thing that makes them visible again might be a supplement you can buy at any pharmacy.

new paper in Cell.
let's talk about arginine.
🧵

[Jaime Pascual @Jaimelikes]

Coffee time

[Lori Shemek, PhD @LoriShemek]

Good News for Those Who Enjoy Coffee. ☕️

Coffee has health and longevity benefits thanks to these two polyphenols: Caffeic Acid and Chlorogenic Acid.

Caffeic Acid: This compound has antioxidant and anti-inflammatory properties. Research suggests it might contribute to reducing oxidative stress, which is linked to aging and chronic diseases.

Chlorogenic Acid: Also known for its antioxidant properties, chlorogenic acid has been studied for its potential in managing blood sugar levels, reducing blood pressure, and combating inflammation, all of which could theoretically contribute to longevity.

Antioxidant Activity:
Polyphenols in coffee help neutralize free radicals, which are implicated in cellular damage and aging.

Anti-inflammatory Effects: Both caffeic and chlorogenic acids have shown anti-inflammatory effects, potentially reducing the risk of chronic diseases associated with inflammation.

Coffee, like green tea, has been solidly associated with health and longevity benefits.

[Jaime Pascual @Jaimelikes]

Coas a mejorar.

[David Sinclair @davidasinclair]

Dim those evening lights and TV

[David Sinclair @davidasinclair]

Dim those evening lights and TV

[Jaime Pascual @Jaimelikes]

@davidasinclair What dosis is safe/ effective for that purpose ( I suppose Experimental)?

[Jaime Pascual @Jaimelikes]

Tadanafilo y demencia

[David Sinclair @davidasinclair]

I take low-dose daily tadalafil for long-term organ health, especially the brain. Vascular dementia is the second most common and most preventable cause of dementia

[Jaime Pascual @Jaimelikes]

@Dijochoeu Un jefe no te dice que renuncies, te echa y punto, sobre todo si no rindes lo esperado en tu trabajo, como es el caso y encima cobras un pastón. Los futbolistas tienen un régimen especial que permite cumplir tu contrato jurgues o no. No hay discusión, te lo tragas con patatas.

[Jaime Pascual @Jaimelikes]

@balaidos79 El marcador electrónico no va arriba ? Se quedo en poner los anclajes que faltaban en la grada de marcador.

[Jaime Pascual @Jaimelikes]

@MCeleste1923 @RCCelta @bayer04_es Haciendo tiempo ( 1 an̈o) para seguir haciendo limpieza y fichar de verdad ?

[Jaime Pascual @Jaimelikes]

Review your feet.

[Metabolic Uncle @MetabolicUncle]

HOW YOUR FEET CONTROL YOUR SLEEP

Most sleep advice tackles the mind. Very little attention goes to a simple vascular event that happens inside your feet every evening. Your ability to fall asleep and stay asleep depends on how efficiently your body dumps core heat, and the soles of your feet are the primary escape route.

Feet house a dedicated network of high-flow shunts that turn passive skin into active biological radiators. When these shunts stay open, warm blood rushes into the feet, thermal energy radiates into the cool bedroom air, your core temperature drops, and the brain responds by shifting into sleep mode. When they close, you lie awake with a warm torso, a racing mind, and cold toes.

These shunts are uniquely built for rapid heat exchange. Most skin routes blood through tiny nutrient-delivering vessels called capillaries. The hairless skin on your soles and palms takes a shortcut. Small arteries connect directly to large venous networks, skipping nutrient exchange entirely and focusing solely on moving heat out of the body.

Alertness, stress, and cold exposure keep these shunts clamped shut through nerve signals. As bedtime approaches and that alertness fades, the shunts should relax. Cold air hitting bare feet triggers a reflex that keeps them locked tight. The solution is remarkably simple. Loose, breathable bed socks in a room cooled to around 23°C insulate the skin just enough to prevent that reflex.

Research tells a compelling story about what happens when you get this right. In controlled crossover studies, socks held foot skin temperature 1.3°C higher than the bare-foot condition. That small temperature bump opened the shunts wide. The results were meaningful. People wearing socks fell asleep 7.5 minutes faster, slept 32 minutes longer overall, and improved their sleep efficiency by 7.6 percent.

Core body temperature did not average out lower across the whole night, which makes sense. The socks smooth the rate of core cooling precisely at the critical transition into sleep rather than changing the overnight thermostat setting.

The neurological link that turns warm feet into a sleep trigger is straightforward once you see it. Researchers measure something called the distal-to-proximal skin temperature gradient. Subtract thigh or torso temperature from foot temperature and you get a number that predicts sleep latency better than core temperature, heart rate, or even melatonin levels. A widening gradient means intense peripheral heat dissipation.

Warm-sensitive neurons in a specific brain region detect this peripheral warmth and respond by downregulating alertness signals and shifting the body into relaxation mode. Heart rate drops, muscle tension fades, and deep sleep arrives. Because the sensory signal starts in the feet, anything that keeps foot vessels from dilating, such as cold exposure, a room that is too warm, or socks that are too tight, delays the whole cascade.

Important boundaries exist. In older adults, the spontaneous nighttime rise in foot skin temperature is often blunted due to structural stiffening of arteries and reduced vascular reactivity. Deliberate foot warming with bed socks does not reliably accelerate sleep onset in elderly insomniacs. However, warming the torso or thighs by as little as 0.4°C cuts sleep-onset latency by 18 percent in healthy older people and by 28 percent in elderly insomniacs.

The thermoregulatory system still responds to external heat when applied to larger surface areas. The sock-based studies also come from small laboratory cohorts in tightly controlled conditions, so individual results vary. A bedroom that is too hot defeats the mechanism. A pair of tight socks does the same. Comfort across the whole body, not just the feet, is necessary for the sleep cascade to proceed.

The basic remedy is simple. Loose, natural-fiber bed socks in a cool room. A warm footbath before bed can prime the system. Choosing cotton or wool instead of synthetics matters.

The full practical application, with every material choice, timing, and adjustment explained in detail, arrives in the attached Part 2, along with the bullet action points in Part 3.

[Jaime Pascual @Jaimelikes]

Buen articulo

[Jaime Pascual @Jaimelikes]

Buen articulo

[Dalton (Analyze & Optimize) @Outdoctrination]

Vitamin C lowers blood pressure by ~20 points in clinical trial.

500 mg / day for 6 weeks here.

Vitamin C, by limiting the excessive free radicals, thus spares nitric oxide, preventing it from being consumed.

Vitamin C has also been shown to help in endothelial function - its anti-inflammatory / antioxidant properties help this single cell layer within the vasculature to respond to changes in blood flow more effectively.

[Jaime Pascual @Jaimelikes]

@TopoBalaidos @ABravoCameselle 60 millones de liras turcas

[Astronomy Vibes @AstronomyVibes]

🚨: Neuroscience confirms that brains cells are directly influenced by self-talk, the internal dialogue or conscious thoughts.

[Jaime Pascual @Jaimelikes]

Inflamaging

[Andrew Panella @Longevity_EDU]

Inflammation.

The hidden cause of every chronic condition from heart disease to obesity.

10 dead-simple methods to cure your inflammation:

1. Grounding

[Jaime Pascual @Jaimelikes]

@DavidMKeyes Perhaps it's a pang of conscience that keeps you awake at night?

[Jaime Pascual @Jaimelikes]

@frank300Colon Now that you have learned some geography by discovering Ceuta, try to learn some history. You can do it."