Jason Klein

MD/PhD, Mohs Surgeon-Scientist
Genetics of skin cancer lab @ University of Colorado

[Jason Klein @jasoncklein]

It's our 1 year lab anniversary at the intersection of genomics and skin cancer at University of Colorado.
Thank you to our amazing funding sources: @dermfoundation @cancerleagueco ACMS Foundation @pathologywatch @cucancercenter @cudermatology

[Jason Klein @jasoncklein]

Here is my latest review paper on molecular drivers in rare soft tissue sarcomas. Look forward to sharing a lot of exciting findings for these tumors in the coming years. @MDPIOpenAccess

https://t.co/N4ZZt1718b

[Jason Klein @jasoncklein]

Excited to share my latest work published in @BioMedCentral Molecular Cancer with the @hon_lab using scRNA-seq and the TCGA-sarcoma cohort to identify a novel biomarker in soft tissue sarcomas.

https://t.co/c39J5YWyaA

[Jason Klein @jasoncklein]

On hyperdrive today.
AM: 9 patients, 5 biopsies, 1 surgery
PM: Midiprep, 6 gel extractions, 2 dna extractions, pcr, cell culture

[Jason Klein @jasoncklein]

@JAMADerm So thanksgiving for the amazing patients we get to see everyday, who are excited about promoting and contributing to the field!

[JAMA Dermatology @JAMADerm]

This case report describes a large, purpuric plaque involving most of the right face with associated periorbital swelling but without ulceration. https://t.co/Cq1Fkk6DjZ

[UTSW Dermatology @UTSWDerm]

First year spotlight! 💡 Jason Klein completed his MD/PhD at @UWMedicine @DermatologyUW! He enjoys triathlons, marathons, and making homemade ice cream and bagels 🥯 🍦. He hopes to apply his background in genomic technology for the treatment of skin diseases. #dermtwitter

[AGBT - Advances in Genome Biology and Technology @agbt]

Jason Klein from @UW detailed three design critieria for MPRAs for the @agbt General Meeting. He examined the systematic evaluation of the design and context dependencies of the massively parallel reporter assays. #AGBT21

[Jason Klein @jasoncklein]

Excited for day 2 of AGBT. Tune in for my talk at 11:30AM EST.

[AGBT - Advances in Genome Biology and Technology @agbt]

Day 2 of the @agbt General Meeting.
Grab some coffee and settle in, there's a lot on the agenda today, including @NobelPrize Winner Dr. Greg Semenza from @HopkinsMedicine.
Check out the full agenda in the theater. #AGBT21

[Jason Klein @jasoncklein]

My latest work. We further developed a method to assemble long pieces of DNA for functional analysis and systematically compare several MPRA designs. Great collab with @vagar112 @TakaInoue5 aidan @bethkarenmartin @JShendure @NadavAhituv
https://t.co/v6oOzCwptl

[Jason Klein @jasoncklein]

My work with @EricSpana at Duke identifying mutations in AANAT1 as the cause for the speck phenotype, described over 100 years ago, was published this week. Read the full story here: https://t.co/WOUhtaHUsI

[Jason Klein @jasoncklein]

Check out my latest preprint with @EricSpana from Duke. We identified the Drosophila speck phenotype, first identified in 1910 as the Arylalkalamine N-acetyltransferase (AANAT1) gene https://t.co/ew3zQo14fd

[Jason Klein @jasoncklein]

@kellystevenslab @JShendure @NatureComms That would be really interesting! Of the differential snps, none of the GWAS separated inflammatory v non-inflammatory OA.

[Jason Klein @jasoncklein]

@GrainOfScience @JShendure @vagar112 It was great to work with you and the Loughlin lab! Thanks again for everything

[Jason Klein @jasoncklein]

Excited to share my latest work prioritizing genetic variants in osteoarthritis using MPRAs. Great collaboration with Aidan Keith @GrainOfScience @vagar112 and others https://t.co/gnhbwT0X9w

[Jason Klein @jasoncklein]

Interested in functional characterization of enhancers? Check out my latest preprint with @JShendure comparing 9 different MPRA designs, and the effect of orientation and length context. With @NadavAhituv and co-led by @vagar112 Aidan Keith Taka Inoue https://t.co/PtYufGCNj8

[Seungsoo Kim @seungsookim10]

Congrats to @SG_Swygert and co-authors! It’s always an honor to get a haiku from @ChromatinHaiku

[Will Chen @wchenomics]

My first work in @JShendure lab is now online. We provides new insights into Cas9 cleavage and DSB repair and trained a model that can accurately predict the repair outcomes and their relative frequencies (web tool online soon). https://t.co/FlqmgxyLzD

[Jason Klein @jasoncklein]

Great review of my recent work on enhancer evolution in the primate lineage. https://t.co/4QDwOa8cKf