John Mindur

Sr Scientist in Pharma | Formerly @SwirskiLab @MGHCSB @HarvardMed & @RutgersU @RWJMS

[John Mindur @jemindur]

Super thrilled to see the second piece of my PhD studies out today! Huge thanks to my amazing mentors and collaborators!!! @SwirskiLab @cam_phd, Mate, Atsushi, and the whole team during my time in @MGHCSB!

[Cameron McAlpine @cam_phd]

We are thrilled to share the first publication from the McAlpine lab! Out today in @ImmunityCP.

“Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis”

@IcahnMountSinai @SinaiHeartBlood @SinaiBrain

https://t.co/WlWY1fFRa9

[Frontiers - Immunology @FrontImmunol]

New Research: Th1-related transcription factors and cytokines in systemic lupus erythematosus: Systemic lupus erythematosus (SLE) is an inflammatory disorder related to immunity dysfunction. The Th1 cell family including Th1 cells,… https://t.co/qmx1tOnhDB #immunology

[Waggoner Lab @LabWaggoner]

Anti-inflammatory actions of GLP-1RAs to reduce TLR-mediated inflammation require CNS GLP-1R signaling @Cell_Metabolism @DanielJDrucker
https://t.co/GfIwhXQ3lJ

[Waggoner Lab @LabWaggoner]

REVIEW @NatRevGastroHep @CamilleDanne
Neutrophils: from IBD to the gut microbiota
https://t.co/s9qc1Ij6rg

[Immunity @ImmunityCP]

RNA vaccines: A transformational advance https://t.co/7M3nxR9Hsc

[Cameron McAlpine @cam_phd]

Some of our emerging concepts on the influence of IL-3 in the brain.
https://t.co/TqYsj5FLRY

[Dr. Hiutung Chu 朱曉彤 @chulab.bsky.social @theChuLab]

Exciting news! Our lab’s first paper is published in JEM 🎉 Led by Adriana Vasquez Ayala @avayala14, we show that commensal bacteria, such as Bacteroides fragilis, employ type IFN pathways to promote immune tolerance. https://t.co/YjWlPdM3Oa

[Waggoner Lab @LabWaggoner]

Resident memory-like regulatory T cells locally record adaptive immune responses in each lymph node @SciImmunology @ugur_milas #Pabst
https://t.co/5ZXP67y60b

[Nan Zhang @NanZhangWistar]

Combining β-glucan and CD40 agonist activates #macrophages and reverses #PDAC progression through Dectin-1 and IFNg+ T cells (and other unknowns🤨😉) but not MHC-I or perforin. Beautiful and important study by Greg Beatty ⁦⁦⁦⁦@PennMedicine⁩ https://t.co/Z6XkjGpPZe

[Waggoner Lab @LabWaggoner]

IL-1β-mediated adaptive reprogramming of endogenous human cardiac fibroblasts to cells with immune features during fibrotic remodeling @JamilaSiamwala
https://t.co/8YlMO5cjBa

[Iannis Aifantis @iannisaifantis1]

Out today @CellCellPress our latest work on peptide:MHC class I expression & degradation and the discovery of a novel protein complex potentially important for T cell recognition in cancer. A great collaboration with @jwang133 @nyugrossman #Immunotherapy
https://t.co/VWZLY3LAzY

[Immunity @ImmunityCP]

Online now: Lymph node sharing between pancreas, gut, and liver leads to immune crosstalk and regulation of pancreatic autoimmunity https://t.co/4X443t5hUu

[Immunity @ImmunityCP]

Online now: Cell-autonomous regulation of complement C3 by factor H limits macrophage efferocytosis and exacerbates atherosclerosis https://t.co/p80kla1WdR

[Waggoner Lab @LabWaggoner]

Antigen-presenting aged neutrophils induce CD4+ T cells to exacerbate inflammation in sepsis @jclinicalinvest
https://t.co/QyPlPVAS3t

[Matthias Nahrendorf @MatthiasNahrend]

📢Completely new monocyte subsets‼️ 🔥💥🔔

Orthogonal to the markers we know (which may just be a function of cell age???)

Limited plasticity of monocyte fate and function associated with epigenetic scripting at the level of progenitors https://t.co/acEyzIG4Uu

[Waggoner Lab @LabWaggoner]

Hypoxic zones in #glioblastoma attract, sequester, and reprogram tumor-associated myeloid cells and cytotoxic T cells into an immunosuppressive state @ImmunityCP @SattirajuA @LabFriedel
https://t.co/a5OrytD0SE

[Abdel Rahman Daoud @AbdelDaoud20503]

✅ Our work provides the first report of the presence of Th17.1 cells in cardiac sarcoidosis which we found transcriptionally expanded in cardiac sarcoidosis relative to healthy control (defined as RUNX1+ TBX21+ T cells).

[Vanja Lazarevic @VanjaLazarevic5]

Delighted to share our recent @NatImmunol study led by @YuanyuanGao6, @ywangCB, and @dchauss, showing that transcription factor EGR2 controls tissue- and disease-specific functions in pathogenic Th17 cells in the CNS. Many thanks to our collaborators!!!

https://t.co/OPx25oseSi

[John Lukens @LukensJohnR]

TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration @ImmunityCP
https://t.co/NkDOrCt1uG

[Matthias Nahrendorf @MatthiasNahrend]

Macrophages mess with ❤️ rhythm
⚡️
transcriptomics and protein data describe 3-fold expansion of these leukocytes in patients with atrial fibrillation. Among the top expressed genes: osteopontin (SPP1), catalyzing atrial fibrosis and inflammation
❤️‍🔥
https://t.co/a2eMhW3fVH

[Cameron McAlpine @cam_phd]

A big thank you to Dr. Stephanie Dougan and Alice Bertocchi for writing a thoughtful preview on our recent paper!

"IL-3 finds its home in the brain" @ImmunityCP

https://t.co/TkfQXLfatd