Jerrin Thomas George

Postdoc at Wiedenheft Lab 🥼 | Former HFSP postdoctoral fellow at Sternberg Lab| 🧬 CRISPR-Cas enthusiast | Interested in mobile genetic elements

[Jerrin Thomas George @jerrintgeorge]

I am happy to share our work on the mechanism of prokaryotic immunity by a reverse transcriptase associated with an SMC-family ATPase, now published in @NatureComms!
🔗 https://t.co/dqOfQbvJlm
(🧵 on the bioRxiv version ⬇️)

[Jerrin Thomas George @jerrintgeorge]

I am super excited to share our work uncovering the structure and mechanism of an ATPase-associated reverse transcriptase (RT) involved in prokaryotic antiviral defense, now available as a preprint on bioRxiv!🧬🦠🔬
https://t.co/ARADc03qZ1
🧵👇

[Israel Fernandez @IsraelF96135088]

Today, our work in partnership once again with @SternbergLab presenting the structures of several DRT10 bacterial defense systems and comprehensive analysis of their mechanisms of action is published… very happy!
Great work guys!
https://t.co/0y14n2R2CX

[Tominaga K. (tomiken) @pacyc1841]

How bacterial immune systems sense phage infection | Nature Reviews Microbiology https://t.co/SV2gIV0gH2

[Andrew Santiago-Frangos, PhD @SantiagoFrangos]

Our lab's first preprint! The antiphage protein Tiamat is an ATPase and DNase with homologs across the tree of life. What started as undergrad Shirley Yuan's summer project grew into a paper and a collaboration with @jpkbravo's group. Link: https://t.co/f8aqlYO50e

[Di Jiang @dijiang319]

Today @ScienceMagazine A noncontiguous code for RNA-guided DNA recognition at the origin of CRISPR-Cas | Science https://t.co/PsCKtw9ogX

[Sternberg Lab @SternbergLab]

Just published! IStrons are a unique class of transposable elements that pack three distinct functions in one sequence. Here, we used pooled library mutagenesis and high-throughput sequencing to systematically map the sequence and structural features that govern these functions.

[Tominaga K. (tomiken) @pacyc1841]

Large eukaryotic DNA viruses encode ESCRT machinery for membrane remodelling | Nature Microbiology https://t.co/5p815vbljR

[Sternberg Lab @SternbergLab]

Out now! In collaboration with Hiroshi Nishimasu's lab, we uncover how a dual reverse transcriptase immune system builds double-stranded DNA from both RNA and protein templates.
https://t.co/mmJtWT1MgL
Previous thread for the preprint: https://t.co/hlopTH0tlH

[Tominaga K. (tomiken) @pacyc1841]

Diverse bacterial pattern recognition receptors sense the core phage proteome | Nature https://t.co/7yKYUGTvs8

[nature @Nature]

Nature research paper: CRISPR–Cas regulates expression of embedded anti-phage defence systems

https://t.co/5GDtUPDqUZ

[Rafa Pinilla-Redondo @rafapinilla92]

1/10
🚨Preprint! One RING to rule them all (phages)👑💍⚔️

Bacteria build giant DNA-scaffolded RNase rings (larger than the ribosome!) to shut down viral infection🧬🧵👇
🔗https://t.co/NNvYtwvtjA

[Artem Isaev @Artem_Isaev_]

Thrilled to share! We present the structure of a prototypical P2 OLD and reveal that its tRNAse activity is triggered by ssDNA hairpins in phage origins or unresolved termini in RecBCD-deficient cells.

Great team effort with Wang, Bikard & Nudler labs.

https://t.co/A0xVKJZmce

[Israel Fernandez @IsraelF96135088]

We and @SternbergLab have a new cool story!
Working with Josephine Ramirez and @QixiangHe we describe structures of two RNA/protein complexes of the phage defense system DRT10. The architecture features an RT- protein dimmer wrapped by an RNA molecule!
https://t.co/7XiWADrxVb

[Tominaga K. (tomiken) @pacyc1841]

Balancing of immune activation and suppression during phage infection | bioRxiv https://t.co/i1AQKpUYbn

[Nature Microbiology @NatureMicrobiol]

Functional diversity of phage sponge proteins that sequester host immune signals https://t.co/fJuvOtZYW1 #MicroSky

[Rafa Pinilla-Redondo @rafapinilla92]

Phages invented sgRNAs before humans!!

Obviously, for mischief… 😈

Loved seeing this story unfold!
https://t.co/bRrxAHpgPG

[Israel Fernandez @IsraelF96135088]

We had a little contribution to the @SternbergLab master piece published here yesterday👇🏼
Congrats to all !

https://t.co/60YpC9LqJ3

[Seraina Oberli @OberliSeraina]

Excited to finally share our preprint! 🧬🚀
Really grateful for the amazing teamwork with Giada Finocchio, @SternbergLab, @Michael__Sch and Martin Jinek 🙌

[Tominaga K. (tomiken) @pacyc1841]

The selfish ribosome | PLOS Biology https://t.co/liXPw1IDaj

[hnisimasu @hnisimasu]

Druantia, Druantia, Druantia, Druantia🔥🔥🔥🔥
https://t.co/0g9f7ZIOMY
https://t.co/viWnD9pfDm
https://t.co/D2HTeSZk6B
https://t.co/duA0KLsST3

[Jackson Lab @ USU @Jackson_Lab_USU]

Happy to share that our work on Cas12a2 was published in Nature last week. USU Biochemists Show CRISPR Can Selectively Destroy Cells, a Cancer-Treatment Goal https://t.co/34Hp44w0Cf