jeff

building tools to understand the brain and mind
~life is beautiful, all the way up, all the way down~

[jeff @jffbrwn2]

@jlinbio yesss

[jeff @jffbrwn2]

early this year, i came to san francisco to visit some friends.

i wrote a tracking algorithm for some microbubbles they'd injected into themselves (yes, really).

we ended up with some of the most beautiful images of the brain i've ever seen.

[Aleph @alephneuro]

We recently obtained the highest-resolution 3D images of the human brain ever taken from outside the skull. This is the first look.

Introducing Aleph, a research lab building brain interfaces for the telepathic future. (1/n)

[jeff @jffbrwn2]

@levchizhov @alephneuro the tracks and i have a telepathic connection

[jeff @jffbrwn2]

speaking of telepathy, it's only with our team at Aleph that I feel like someone really gets my love for understanding the brain and mind.

to a telepathic future!!!
@_marleyx @raffi_hotter @thomas_rribeiro @levchizhov

[jeff @jffbrwn2]

Full Paper: https://t.co/CYWyNXYgeS
NeurIPS Spotlight: https://t.co/oWWeGgylip
Github: https://t.co/DInRGULZot
Dataset: https://t.co/qqGGMY85VU

[jeff @jffbrwn2]

[1/8] Excited to present our work "ConnectomeBench: Can LLMs proofread the connectome?" at NeurIPS 2025 Datasets and Benchmarks!

https://t.co/oWWeGgylip

[jeff @jffbrwn2]

[7/8] Special thanks to
- @sdorkenw for amazing help during development
- @FarkasTim @Kirjner0 for their awesome engineering
- Annika Vivekananthan for support with labelling
- @EdBoyden for supporting and pushing this work
- @SGRodriques @isaakfreeman for sparking this idea

[Sam Rodriques @SGRodriques]

Today, we’re announcing Kosmos, our newest AI Scientist, available to use now.

Users estimate Kosmos does 6 months of work in a single day. One run can read 1,500 papers and write 42,000 lines of code. At least 79% of its findings are reproducible. Kosmos has made 7 discoveries so far, which we are releasing today, in areas ranging from neuroscience to material science and clinical genetics, in collaboration with our academic beta testers. Three of these discoveries reproduced unpublished findings; four are net new, validated contributions to the scientific literature. AI-accelerated science is here.

Our core innovation in Kosmos is the use of a structured, continuously-updated world model. As described in our technical report, Kosmos’ world model allows it to process orders of magnitude more information than could fit into the context of even the longest-context language models, allowing it to synthesize more information and pursue coherent goals over longer time horizons than Robin or any of our other prior agents. In this respect, we believe Kosmos is the most compute-intensive language agent released so far in any field, and by far the most capable AI Scientist available today. The use of a persistent world model also enables single Kosmos trajectories to produce highly complex outputs that require multiple significant logical leaps. As with all of our systems, Kosmos is designed with transparency and verifiability in mind: every conclusion in a Kosmos report can be traced through our platform to the specific lines of code or the specific passages in the scientific literature that inspired it, ensuring that Kosmos’ findings are fully auditable at all times.

We are also using this opportunity to announce the launch of Edison Scientific, a new commercial spinout of FutureHouse, which will be focused on commercializing our agents and applying them to automate scientific research in drug discovery and beyond. Edison will be taking over management of the FutureHouse platform, where you can access Kosmos alongside our Literature, Molecules, and Precedent agents (previously Crow, Phoenix, and Owl). Edison will continue to offer free tier usage for casual users and academics, while also offering higher rate limits and additional features for users who need them. You can read more about this spinout on our blog, below.

A few important notes if you’re going to try Kosmos. Firstly, Kosmos is different from many other AI tools you might have played with, including our other agents. It is more similar to a Deep Research tool than it is to a chatbot: it takes some time to figure out how to prompt it effectively, and we have tried to include guidelines on this to help (see below). It costs $200/run right now (200 credits per run, and $1/credit), with some free tier usage for academics. This is heavily discounted; people who sign up for Founding Subscriptions now can lock in the $1/credit price indefinitely, but the price ultimately will probably be higher. Again, this is less chatbot and more research tool, something you run on high-value targets as needed.

Some caveats are also warranted. Firstly, we find that 80% of Kosmos findings are reproducible, which also means 20% are not -- some things it says will be wrong. Also, Kosmos certainly does produce outputs that are the equivalent to several months of human labor, but it also often goes down rabbit holes or chases statistically significant yet scientifically irrelevant findings. We often run Kosmos multiple times on the same objective in order to sample the various research avenues it can take. There are still a bunch of rough edges on the UI and such, which we are working on. Finally, we are aware that the 6 month figure is much greater than estimates by other AI labs, like METR, about the length of tasks that AI Agents can currently perform. You can read discussion about this in our blog post.

Huge congratulations to our team that put this together, led by @ludomitch and @michaelathinks: Angela Yiu, @benjamin0chang, @sidn137, Edwin Melville-Green, Albert Bou, @arvissulovari, Oz Wassie, @jonmlaurent. A particular shout out to @m_skarlinski and his team that rebuilt the platform for this launch, especially Andy Cai @notAndyCai, Richard Magness, Remo Storni, Tyler Nadolski @_tnadolski, Mayk Caldas @maykcaldas, Sam Cox @samcox822 and more.

This work would not have been possible without significant contributions from academic collaborators @mathieubourdenx, @EricLandsness, @bdanubius, @physicistnevans, Tonio Buonassisi, @BGomes_1905, Shriya Reddy, @marthafoiani, and @RandallBateman3.

We also want to thank our numerous supporters, especially @ericschmidt, who has been a tremendous ally. We will have more to say about our supporters soon!

[jeff @jffbrwn2]

suppose AI systems can eventually do interesting science. there's no reason their method of information transmission or peer review needs to mirror how we transmit information (e.g. through writing journal articles or blog post). instead assembly code but for scientific reasoning