CogniSphere

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[CogniSphere @jorgensenmc1]

@Cortex_Zero

[CogniSphere @jorgensenmc1]

@KygoApp @DrJesseMorse The GlyNAC trials used 100mg/kg each for glycine and NAC is believed.

[CogniSphere @jorgensenmc1]

@matthewbaszucki New study.

[Medical Xpress @medical_xpress]

In bipolar disorder, insulin resistance and leptin dysregulation tracked with brain volume changes and poorer memory, attention, and executive function. https://t.co/ifeGnE2AuC

[CogniSphere @jorgensenmc1]

@ChrisMasterjohn 3 grams of GAA/creatine reversed my hypersomnia when combined with keto. Keto alone couldnt get me out of that funk.

[CogniSphere @jorgensenmc1]

@CoffeeBlackMD @RussellShaw_MLS Changing my brain metabolism through keto and enhancing creatine synthesis reversed my lethargic anhedonia within a week and made me feel like walking again. 6000 steps a day to 13,000. The walks then fed back in and improved the whole process further .

[Martin Picard @MitoPsychoBio]

The brain is not a machine

[MECFS, MCAS and PTSD @FatigueMe92484]

Research links their interaction to brain energetics, where reduced hypothalamic orexin in narcolepsy correlates with decreased neuronal creatine, suggesting creatine supplementation could support brain energy during metabolic stress, such as sleep deprivation.

In vivo evidence of neuronal loss in the hypothalamus of narcoleptic patients - PubMed https://t.co/zzWLYgBcws

[Sheila Macrine, Ph.D. @MacrinePhD]

Why does life exist? It might come down to the perfect flow. New research suggests the Universe’s fundamental constants are finely tuned to a narrow "sweet spot" that allows liquids—like blood and cellular fluid—to flow properly.
Even a tiny shift in physics could make water as thick as tar, making life impossible. This discovery adds a stunning new layer to the mystery of cosmic fine-tuning!
https://t.co/q1y0Ki5IRu
#ScienceNews #Physics #Biology #FineTuning #QueenMaryUniversity #Evolution #Cosmology #DeepScience #ScienceTwitter

[CogniSphere @jorgensenmc1]

@compoundperf @louisanicola_ I had a major transformation with my treatment resistant anhedonia using creatine’s precursor GAA and keto . I kinda think of it like an electric hybrid car . Need the engine (mitochondria) and the battery (phosphocreatine) optimized together. Not a perfect analogy but useful .

[Louisa Nicola @louisanicola_]

You experience mental fatigue as emotional exhaustion because the brain hides the metabolic problem underneath the psychological one.

Creatine increases phosphocreatine availability inside neural tissue. That matters because cognition is an energy conversion process.

Some of the people calling themselves burned out are operating with a brain running an energy deficit under extreme demand.

That is not mindset. That is bioenergetics.

[Nicole Laurent, LMHC @KetoCounselor]

Even when hypermetabolic cells increase total ATP and the ATP/ADP ratio, they can still experience energy scarcity due to higher energy costs of producing ATP and higher background costs. Why? Because higher metabolic activity can come with inefficiency. And that means more energy is spent to make ATP and to cover baseline demands, which can still produce net energy scarcity.

[CogniSphere @jorgensenmc1]

@digijordan Similar to my sighting.

[Atanas G. Atanasov @_atanas_]

#Gratitude #INPST #SciComm

@ONESA092 @ToshiyukiHorie 
@LEAD_Coalition @chefegomez
@ChrisSylvain @BioactivNatProd
@MerisaCenanovic @Kannan9900
@scientistbiomed @greeneyedlizzie

[Trends in Neurosciences @TrendsNeuro]

'A dimmer switch for reward: the vagus sets the gain'

TINS 'Spotlight' by Hongyun Wang, Shuhan Liu & Ling Bai
https://t.co/GT2t3Gm0VZ

discussing Onimus et al. 2026, Science Advances; Giuseppe Gangarossa group
https://t.co/aqL7qTqKse

[Frank Lipman MD @DrFrankLipman]

In a study, researchers revealed a “hydraulic pump” mechanism that links physical activity to brain health. Every time you tighten your abdominal muscles—even slightly—your brain flushes out harmful waste.
https://t.co/la8jegHR4s

[CogniSphere @jorgensenmc1]

@KygoApp @Dr_Biohacker You look into arugula? One of the highest nitrates levels plus H2S donor Erucin.

[CogniSphere @jorgensenmc1]

I had no results with regular Creatine . When I switched to GAA ( creatines precursor) and keto my hypersomnia and anhedonia lifted within a week . I started tracking my sleep 3 weeks ago and get 88%-96 % every night on 5.5-6 hours sleep. I actually want a few more hours for a few reasons and am trying to figure it out .

[CogniSphere @jorgensenmc1]

ATP regeneration is only one layer; the real target is buffered, low-noise, adaptable energy flow across substrate, membrane, redox, methylation, and recovery systems.

[Medical Xpress @medical_xpress]

Known for gym performance, creatine is also tied to brain-related effects and possible therapeutic uses via energy metabolism, yet its benefits come with limitations that keep the picture unsettled. https://t.co/XMR0pEOqyS

[CogniSphere @jorgensenmc1]

@01Singularity01 @Dan_Jeffries1 The internal voice or inner dialogue represents another layer of information exchange within the individual node no ?

[CogniSphere @jorgensenmc1]

@MLandmeier @edgaralandough Plus high nitrates ! Underrated food for sure.