Jorg Morf

[Jorg Morf @jorgmorf]

Protein-templated synthesis of dinucleotide repeat DNA by an antiphage reverse transcriptase | Science https://t.co/VGnss2REAG

[Ben Shenhar @BShenhar]

New preprint! 🚨
Why has maximal human lifespan barely changed while median lifespan has doubled?
We used a mechanistic mathematical model of aging to find that fundamental aging rates are strikingly conserved across individuals and over time.
https://t.co/9jARhFWnP8
🧵1/n

[Anthony Leung @LeungLab]

What if RNA had a molecular twin?
Our new study w/ the Bedford Lab (MD Anderson) shows poly(ADP-ribose) (PAR) competes with RNA for the same proteins—creating RNA–PAR crosstalk.
Unlike RNA, PAR’s info isn’t in sequence but chain length.
🔗 https://t.co/0WIjbkiHb7
#PARcode

[Bruno Di Stefano @DiStefano_Lab]

1/ Excited to share our new study with @Brumbaugh_JB, now out in @NatureBiotech! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵https://t.co/D7fnkJgNQ6

[Jorg Morf @jorgmorf]

Selective RNA sequestration in biomolecular condensates directs cell fate transitions | Nature Biotechnology https://t.co/gdn5k4PG24

[bioRxiv Genomics @biorxiv_genomic]

Simultaneous measurement of intrinsic promoter and enhancer potential reveals principles of functional duality and regulatory reciprocity https://t.co/LeXnsRNbEc #biorxiv_genomic

[Srinjan Lab @srinjan.bsky.social @srinjan_basu]

New #preprint from the Basu & Stewart labs! We discover a non-catalytic role for H3K4me3 methyltransferase MLL2 in modulating 3D chromatin organisation and mobility as pluripotent cells are primed for differentiation.

https://t.co/iuBeiP6b5H

[Jake P. Taylor-King @wildtypehuman]

Read the @scTrends_update take on the AI arms race to generate single-cell data

https://t.co/2GfiRhwzEW

Thanks @AdamCribbs !

[Jake P. Taylor-King @wildtypehuman]

Our latest @scTrends_update article is now in @CellGenomics: https://t.co/HRaUAjqXbP

Paired with this is our end of year round up:
https://t.co/faq6ASYyCY

Get in touch if you want to be involved!

[Gene Regulation @generegulation]

Chromatin architecture mapping by multiplex proximity tagging [Delamarre et al. 2024] https://t.co/4AhPJf9jR9
▶️Nucleosome maps in 3D with Proximity Copy Paste (PCP)
▶️Connectivity of nucleosomes in S. cerevisiae
▶️Chromatin is predominantly organized in regular nucleosome arrays

[Miha Modic @paraspeckle]

Thrilled to share our latest manuscript on smOOPs, a highly interconnected class of condensation-prone mRNAs with signs of coordinated regulation, encoding functionally related proteins. Shoutout to the incredible team @IraIosub, Jona & @KlobucarTajda. https://t.co/7m80OqIVTl

[Fei Chen Lab @insitubiology]

Happy to share that our new preprint is now live! Read below to learn about our technology for imaging-free spatial genomics!

[Mark Ashe @Markashe]

A bit of advertising for our review. Please take a look - we definitely spent a lot of time on this and dipped our toes well outside our comfort zone!

Orchestrated centers for the production of proteins or “translation factories” - WIREs RNA https://t.co/j5QnZKAltN

[Nature Biotechnology @NatureBiotech]

A community effort to track commercial single-cell and spatial ’omic technologies and business trends https://t.co/suvfo1IJ8m

[Jake P. Taylor-King @wildtypehuman]

Today is the go live day for @scTrends_update! A consortium to both review *commercial* technologies, but also study market trends to assess angles for how technologies may differentiate themselves.

[Schuh Lab @SchuhLab]

Women are born with all their oocytes, which need to stay viable for decades to ensure fertility. How are they maintained for that long?

Our latest research in @NatureCellBio reveals that oocyte maintenance involves exceptional protein longevity. https://t.co/ZiByc9F4hS (1/9)

[D. Allan Drummond @dallandrummond]

What if we used sedimentation to look at RNAs instead of proteins? Behold: @ewjwallace created Sed-seq! And Sed-seq immediately revealed a bunch of surprises. First, whereas a small set of proteins (~15%) condense during stress, nearly all RNAs condense. 6/n

[D. Allan Drummond @dallandrummond]

How do cells efficiently respond to stress? Transcriptional stress responses are well-known—and in our latest study, we discover that cells use biomolecular condensation to redirect translation from old to new mRNAs 1/n https://t.co/pc9v3TdFQU

[Christine Mayr @Mayr_Christine]

Finally out!
We found that mRNAs are not uniformly distributed across the cytoplasm.

mRNA architecture is the strongest determinant for localization.

Subcytoplasmic location of translation controls protein output.
https://t.co/CJW80etwG7

[Joseph Takahashi @CircadianClocks]

Very sad news that Takao Kondo, a great scientist and pioneer of the Cyanobacterial clock system has passed away. RIP. @SRBR_Outreach 訃報　近藤孝男先生（本会名誉会員）がご逝去されました | 日本時間生物学会 https://t.co/9bVRW0w8lK