John Mascola, MD

physician-scientist, science for public health; views are my own

[John Mascola, MD @jrmascola]

@Jasonmmast Congratulations Jason. Well deserved!

[John Mascola, MD @jrmascola]

@EricTopol Depends on definition of significant. In context of total spike antibody response elicited by JN.1, would need to see more serological neutralization data to say this.

[John Mascola, MD @jrmascola]

@BLLPHD Congratulation to Carl for this well deserved recognition!

[John Mascola, MD @jrmascola]

@KizzyPhD @TIME So clear and thoughtful and I hope widely read!

[John Mascola, MD @jrmascola]

@McLellan_Lab @BarneyGrahamMD Such a great day for vaccine science. Congratulations!!

[John Mascola, MD @jrmascola]

@theNASciences @MSMEDU Congratulations Barney!

[John Mascola, MD @jrmascola]

@EJohnWherry @markmpainter Beautiful data and story - and clearly written for all to read. Congrats!

[John Mascola, MD @jrmascola]

@VUMC_Vaccines @IG_lab @AShiakolas Awesome - Congratulations Andrea!

[John Mascola, MD @jrmascola]

@Jasonmmast Thanks Jason, nerdy but useful. We'll all have to get used to this names. . .

[John Mascola, MD @jrmascola]

@McLellan_Lab @ENirenberg @David_RMartinez Also, the VRC/NIH phase 1 study showed that alum adjuvanted and unadjuvanted DS-Cav1 were similarly immunogenic. I was surprised by this, but as Jason notes - preexisting immunity is key here.

[John Mascola, MD @jrmascola]

@McLellan_Lab @BarneyGrahamMD Thanks for sharing this amazing news. Proof of concept for structure based vaccine design!

[John Mascola, MD @jrmascola]

@camilahcoelho Congratulations. And thanks for the educational summary!

[John Mascola, MD @jrmascola]

@McLellan_Lab So funny. Need a lift to stand with Barney - but hey, the beards look good!

[John Mascola, MD @jrmascola]

@GeoffreyHutch11 @BarneyGrahamMD Congratulations Barney - This is a fantastic and well deserved honor!

[John Mascola, MD @jrmascola]

@rishirajgoel Beautiful data and summary!

[John Mascola, MD @jrmascola]

@AShiakolas @IG_lab @croweje @TheBukreyevLab @McLellan_Lab Congratulations on this elegant work Andrea!

[John Mascola, MD @jrmascola]

@BReinfeld @RMedzhitov @LabListon Yes. Cool science of fever! Harry Bernhiem was my professor also at Tufts. Worked in his lab studying endogenous pyrogen (IL1).

[John Mascola, MD @jrmascola]

@EJohnWherry And we hope this holds for Omicron where there is some erosion of vaccine efficacy.

[John Mascola, MD @jrmascola]

@EricTopol A treasure trove of tweets - amazing!

[John Mascola, MD @jrmascola]

@TheBcellArtist With Alpha, Delta, and even Beta, two mRNA immunizations produced reasonably high levels of virus inactivating antibodies. With Omicron, it takes three shots to get there.