Delivery of therapeutic molecules is a major bottleneck for treating a wide range of diseases. Today we describe a new modality for delivering proteins based on an engineered contractile injection system @nature https://t.co/eIAn8MW6jN
Our review on the biosynthesis of fungal maleidrides is out now in @NatProdReports. Read it for a comprehensive overview of the chemical, in vivo, in vitro and in silico analyses conducted on these compounds and their biosynthetic pathways. https://t.co/YUCyHOuJId
Overjoyed to share our work now out in @Nature - massive biosynthetic diversity of the open ocean and new RiPP enzymes brought to you by the incomparable @Lcs_Paoli and team: @SunagawaLab, @piel_lab esp. @HubrichFlorian, @satriaphd, and many more ❤️🎉https://t.co/lewfk3waM3
Finally published! The wollamides and desotamides provide a unique insight in to NRPS evolution. Huge thanks to all involved, especially @barriewilksjic for giving me the opportunity all that time ago! Summary thread to come. @NatureComms@JohnInnesCentre
https://t.co/FHPfXbMh8G
This mind-blowing research in @Nature shows that machine learning can effectively guide enzyme optimization and help create enzymes that degrade all kinds of plastic waste in record time 🤯https://t.co/uGXX98EfKO
What will Nature Water be about? We have prepared a collection of articles from @NaturePortfolio to illustrate the areas (or at least some of them) that we'll cover. Enjoy!
https://t.co/veQztuB6e5
Many thanks to @kate_dMS for highlighting our research @nchembio “Greener Amide Bonds.” Merging enzymes & chemocatalysis for more sustainable synthesis of amides: https://t.co/S7Y5A5kN01
https://t.co/Mh98AmwAYs
Following consultation with the environmental science community, we've updated the eligibility requirements for NERC Independent Research Fellowships.
Find out more 🔽
https://t.co/asi7uNxEhS
Congratulations on another great paper from @MatsudaLab and collaborators! After nearly a century of research on this family of compounds, our understanding of xanthone biosynthesis is coming on leaps and bounds...
Our collaboration work with Prof. Abe and Dr. Mori at Univ. of Tokyo is now out in @angew_chem. We provide a detailed characterization of the tetrahydroxanthone-forming enzyme! https://t.co/KID77Dm2kc
Our review on the core steps to the azaphilone family of fungal natural products has just been published in @ChemBioChem. We use the fantastic bioinformatic tools developed by @clmgilchrist to identify potential unexplored genetic and chemical space: https://t.co/bg9lVdtSpZ
Really excited that our review in @NatureRevGenet is out: https://t.co/8vcLPgxSXv. Mining genomes across the tree of life. Was great fun writing this with @Tristan_enzymes and @BradMoore_SIO !
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Our new paper is now out in @JOC_OL. Discovery of four new fungal meroterpenoids along with an αKG-dependent enzyme for spirocyclopentanone synthesis! https://t.co/CUhkOFGDqy
A sci-fi story about an early career scientist who gets an early career scientist’s grant to go back in time and submit his own PhD a year earlier, resulting in the future version of the early career scientist not qualifying as an early career scientist any more