Kaveh Daneshvar

Gene & RNA Therapies | Building a new venture. Past: @Arbortx | @Tome_bio, @FlagshipPioneer, and @Harvard

[Kaveh Daneshvar @kavehdaneshvar]

Our findings @NatureCellBio suggest a role for lncRNA-protein condensates in transcriptional regulation. We show that a lncRNA promotes the nucleation of bromodomain protein condensates on active chromatin and control their transcriptional activity.
https://t.co/qEISd28V8n

[WayBio @WayBiosolutions]

WayBio is at #SIMBAM2026 this week, exhibiting our DNA foundry platform. If you want to see how our foundry is helping protein engineering teams build DNA variant libraries, or if you're running enzyme engineering programs of your own, come find us in the exhibit hall.

[WayBio @WayBiosolutions]

We're WayBio, a DNA foundry based in Cambridge, MA. We've built platform technology that lets us generate variants of large genes without resynthesizing them. Engineering a large gene or enzyme? Let's talk.

[Kaveh Daneshvar @kavehdaneshvar]

@HawleLab @UNCCBiology @ValeriaUva1 I think I see my old bench in the back! This brought back a lot of memories 🙂

[Kaveh Daneshvar @kavehdaneshvar]

@GallowayLabMIT From the perspective of RNA stability, I’m going with Myc!

[Kaveh Daneshvar @kavehdaneshvar]

@kischober @SciImmunology Any hypothesis on whether the difference in antigen expression kinetics of mRNA and Adenovirus vaccines can contribute to class switching?

[Alexandro Landshammer, PhD @Langsammer03]

🚨!!!Preprint Alert!!!🚨 I am super-delighted to share our work co-led with @adrianobolondi describing the discovery and characterization of a novel lncRNA, LNCSOX17, a key regulator of human definitive endoderm. #Meissner Lab @MPI_MolGen. A🧵1/11 https://t.co/RbO2tRJLID

[Jonathan Gootenberg @jgooten]

New preprint! How do you insert large genes efficiently + programmatically? CRISPR-based methods are programmable, integrases are efficient. Why not combine them?
PASTE places short (~45bp) integrase landing sites that serve as beacons for insertion (up to 36kb)!
@omarabudayyeh

[Kaveh Daneshvar @kavehdaneshvar]

@goodreads Disgraced, by @ayadakhtar

[Kaveh Daneshvar @kavehdaneshvar]

@oligopain @YSPTSPS Eastern standard is gone for good.

[Kaveh Daneshvar @kavehdaneshvar]

@innalax Very helpful! Thank you!

[Kaveh Daneshvar @kavehdaneshvar]

Any suggestions for a high-yield T7 IVT kit that makes 5'-capped, 3'-poylA tailed mRNA with modified nucleotides (e.g. 5mCTP, ψUTP) to avoid cell immune response?

[Kaveh Daneshvar @kavehdaneshvar]

@TrumanLab @TimoWitten @lpachter Dofferent versions of such websites/databases have been tested, but they never caught on. Not sure why.

[Kaveh Daneshvar @kavehdaneshvar]

@MehrsaBaradaran Side note: I have been greatly inspired by your reading. Thanks for sharing your reads and writing reviews on Goodreads.

[Kaveh Daneshvar @kavehdaneshvar]

@SztubaSolinska Congradulations!

[Kaveh Daneshvar @kavehdaneshvar]

I wonder what type of biases and discriminations this algorithm is going to reinforce. Also, reminds me of this good book on a related topic: https://t.co/v1bttUJcO0

[Nature Portfolio @NaturePortfolio]

A machine-learning model can be used to predict the future “impact” of research published in scientific literature, according to a @NatureBiotech paper. The model could aid in the construction of diversified, impact-optimized funding portfolios. https://t.co/SX592OYIsj

[Lee Zou @LeeZou8]

Glad to share our latest paper on a new role of RNA in homologous recombination. Thanks to members of my team and our collaborators! RNA transcripts stimulate homologous recombination by forming DR-loops | Nature https://t.co/KrqQbLCpBD

[Mehrsa Baradaran @MehrsaBaradaran]

My boomer parents can't identify spam emails. My zoomer kids can't identify junk mail. Gen X FTW!

[Kaveh Daneshvar @kavehdaneshvar]

@CurtisRFrench @SSarabipour @AdrianoAguzzi Preprints are not just for citations. You can actually “read” and “evaluate” a preprint without the help of a peer reviewer or an editor.

[Kaveh Daneshvar @kavehdaneshvar]

@MartinaZaffera1 Fantastic! Just added it to the list of papers I will be talking about in my RNA therapeutics lectures.