Kevin Lee

Catholic | husband | father | MD, PhD. seeking better outcomes for cancer patients. nutrition. metabolic interventions #LCHF #stats #clincialtrials #radonc

[Simona Cristea @simocristea]

I need to raise awareness about an important point in #scRNAseq data analysis, which, in my opinion, is not acknowledged enough:

‼️In practice, most cell type assignment methods will fail on totally novel cell types. Biological/expert curation is necessary!

Here's one example👇

[Prof. Nikolai Slavov @slavov_n]

Let’s talk about proteins whose abundance generally does not correlate the abundance of the transcripts that templates them.

Give examples.

[Kevin Lee @kevin_radonc]

@drbeckta @HenningWillers @DrChowdharyMD @HenryParkMD @JCO_ASCO 60Gy is probably enough dose if given in 1.5Gy per fraction BID…

25% absolute improvement in OS at 2 years…

https://t.co/6AYDoK1EtM

[Kevin Lee @kevin_radonc]

@TimShowalter1 You are unavailable for DMs

[Kevin Lee @kevin_radonc]

@drlw2309 It may be interesting to add a note in your informative graphic that there is also another trial with the same name (ARTDECO) in esophageal cancer which also was dose escalation and also was a “negative” trial.

[Kevin Lee @kevin_radonc]

@MarcusDGon Did they serve sugary beverages and carbohydrate rich finger foods at the event?

[Kevin Lee @kevin_radonc]

@drlw2309 I recommend xp pen. It is a touch screen designed for artists so it is very precise and responsive. It’s Not a stand alone computer though.
I use it almost daily at work for contouring.

https://t.co/9vRemgqj6z

[WesTalcottMD @TalcottMd]

Our new work out in PRO, prospectively "stress-testing" physician chart rounds as performed at a typical North American rad onc center, shows room for improvement in detecting errors in treatment plans. @ASTRO_org
https://t.co/W3WY8M9SNM

[Kevin Lee @kevin_radonc]

@VickersBiostats I would classify that argument to be in the high-risk group for truth.

[Kevin Lee @kevin_radonc]

@nlindenberg @JackWestMD Agreed. For instance, 60Gy in 30 fractions for SCLC. BID is the real MVP

[Drew Moghanaki @DrewMoghanaki]

Today’s update on randomized trials investigating the life-prolonging value of SBRT for people with stage IV lung cancer. #ASCO20 #lcsm #radonc

[Drew Moghanaki @DrewMoghanaki]

Once again, we have someone Pushing for SBRT in Oligometastatic Lung Cancer. #radonc #lcsm @jillfeldman4

[Kevin Lee @kevin_radonc]

@ASTRO_org I think @EvanThomas84 would be a great choice!

[Kevin Lee @kevin_radonc]

@NoahHaber Or this could be a really good explanation as to why retrospective database analyses may not give true effect measure.
Confounding by indication. Selection bias. Etc
This is why surgery looks ⬆️ than radiation in treating cancer with retro DB studies but often not with RCTs.

[Kevin Lee @kevin_radonc]

@NoahHaber If this was a randomized intervention, there is likely a significant imbalance in allocation. This picture is the reason it is: 1. Appropriate to stratify by factors that affect the response variable, and 2. Appropriate to account for those variables in the stat model

[UAB Radiation Oncology @UABradonc]

UAB ranked #25 cancer hospital in nation, and #1 in the Southeast in US News Cancer Hospital Rankings this year.

Proud of our many talented doctors, nurses, researchers, and healthcare professionals. @uabmedicine @ONealCancerUAB

https://t.co/iglEOhIku0

[Kevin Lee @kevin_radonc]

@statsepi Have you subtracted out the inch of crust perimeter of the pizzas before calculating area?

I want to know about area of cheesy, sauce-y, topping covered goodness per unit currency.

[Prof Darrel Francis ☺ Mk CardioFellows Great Again @ProfDFrancis]

Dear Nobel Prize Committee,

I would like to claim my Nobel Prize please.
For curing cancer.

Can you post me my medal, or do I have to come and collect it in person?

#FOAMED #MedTwitter #Tweetorial

[Bishal Gyawali, MD, PhD, FASCO @oncology_bg]

I have an onco-policy joke. It won’t get a good response but it will be approved.