We, the Howe and Fish Lab Members, walked 5K for #WeWalkUHNITED#SupportUHN.
If you share our commitment to advancing lifesaving care and research to support patients & families, please donate (https://t.co/rjsQMgxlxk) to help us reach our goal. 🙏
@kat_howe@FishLab_UHN
Research | Cantu et al. identify the common and unique transcriptional regulatory networks in the endothelium of six different organs across development and show that these same transcriptional regulators can reprogram endothelial function in vitro.
👉https://t.co/C4aPooUQSB
Check out a new paper from our laboratory! Congrats to Dr. Sarvatit Patel @sarv_PhD who completed this work during his post-doctoral studies in the @kat_howe laboratory. Entire team makes this happen - amazing work everyone. Story on endothelial cell-monocyte communication in age-related vascular inflammation! @CoreyScipione@FishLab_UHN and Kai Ellis
https://t.co/YD50ji9VO6
Excited to share the final chapter of my PhD that just came out @NatureComms! Thank you @KarimMekhail, our collaborators and the team. https://t.co/IBunFdo5Ay
Read the latest #research on #Nucleolar RNA Polymerase II, #ribosome biogenesis, and #protein synthesis (in final form). Congrats to first-author @N_Khosraviani and our amazing coauthors and collaborators.
https://t.co/iKXZ6SDIux
BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
It’s an honour to receive the 2024 Bigelow Award & Book Prize from the Cardiovascular Sciences Collaborative Specialization (CSCS) program! Grateful to be part of an amazing team @FishLab_UHN@kat_howe and to be working on the brain Arteriovenous Malformation project! @UofT_LMP
Excited to be a part of this work from Josh Wythe. 3D uCT of KRAS-driven brain AVMs reveals stereotyped locations that coincide with endogenous Kras. Human bAVMs show spatial restriction. MEK inhibitors in mice and paediatric patients impedes progression.
https://t.co/zY2Dg6jZKS
Our latest @Nature paper is out! We show that transplanting mitochondria into endothelial cells boosts their ability to form blood vessels in ischemic tissues, with mitophagy as the key mechanism. A potential game-changer for vascular cell therapies. https://t.co/ViscFIc9sv